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公开(公告)号：US09814791B2
公开(公告)日：2017-11-14
申请号：US14789584
申请日：2015-07-01
CPC分类号： A61K49/0414 , A61B6/032 , A61B6/145 , A61B6/466 , A61B6/481
摘要： Dental contrast formulations (“fillers”) of tailorable X-Ray radiopacity and methods for their use are provided. The disclosed fillers include mixtures of solid particles suspended in a biocompatible fluid. The solid particles contain one or more X-ray radiopaque materials. The biocompatible fluid can also contain one or more soluble X-ray radiopaque components. By controlling the composition of the solid particles, the composition of the biocompatible fluid, and the loading of the solid particles in the biocompatible fluid, the X-ray radiopacity and stability of the filler can be tailored to allow for improved discrimination of the filler within periodontal pockets, relative to adjacent soft tissue and teeth, so that the 3-D shape, volume, and depth of the pocket can be precisely and rapidly determined by X-Ray imaging.
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2.发明申请公开(公告)号：US20160279166A1
公开(公告)日：2016-09-29
申请号：US15173223
申请日：2016-06-03
发明人： Yuya YOSHIMURA , Satoru ISHIHAMA
IPC分类号： A61K33/08 , A61K9/00 , A61K31/715 , A61K9/20
CPC分类号： A61K33/08 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2072 , A61K31/715 , A61K31/765 , A61K49/0414 , A61K49/0423 , A61K2300/00
摘要： A treating agent for the examination or operation of the large intestine which has high examination precision or facilitates an operation and can be administered with a small amount of water. The treating agent for the examination or operation of the large intestine contains magnesium oxide particles and is used to be orally administered before an examination or operation.
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公开(公告)号：US06544496B1
公开(公告)日：2003-04-08
申请号：US08481131
申请日：1995-06-07
申请人： Ulf Schröder
发明人： Ulf Schröder
IPC分类号： A61B813
CPC分类号： A61K49/1863 , A61K49/0414 , A61K49/225 , A61K51/1255 , A61K2123/00 , G01R33/5601
摘要： The present invention relates to a method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spherical particles comprising a matrix enclosing a gaseous contrast agent which reflects sound waves, said matrix being a biocompatible, biodegradable, non-immunogenic non-polyamino acid synthetic polymer; and generating an ultrasonic image of said subject. The polymer may be selected from the group consisting of carbohydrates, carbohydrate derivatives and non-polyamino acid synthetic polymers.
摘要翻译： 本发明涉及对比度增强超声波诊断成像方法，其包括对受试者施加对比度增加量的球形颗粒，所述球形颗粒包含包含反射声波的气体造影剂的基质，所述基质是生物相容的，可生物降解的，非免疫原性的非 - 聚氨基酸合成聚合物; 以及生成所述对象的超声波图像。 聚合物可以选自碳水化合物，碳水化合物衍生物和非聚氨基酸合成聚合物。
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公开(公告)号：US20020064502A1
公开(公告)日：2002-05-30
申请号：US08997748
申请日：1997-12-24
IPC分类号： A61B005/055
CPC分类号： A61K49/1887 , A61K49/0002 , A61K49/0414 , A61K49/1845 , A61K49/1848 , A61K49/1857 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K49/1875 , C08B30/18 , C08B37/0021 , G01N2400/14 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/86
摘要： Agents containing magnetic particles are suitable for use in enhancing images in diagnostic procedures, e.g., via x-ray, ultrasound or especially NMR. Preferred particles are based on metals, e.g., iron, cobalt or nickel, double metal oxides/hydroxides or complexes thereof.
摘要翻译： 包含磁性颗粒的试剂适合用于诊断程序中增强图像，例如通过x射线，超声波或特别是NMR。 优选的颗粒基于金属，例如铁，钴或镍，双金属氧化物/氢氧化物或其复合物。
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公开(公告)号：US5976500A
公开(公告)日：1999-11-02
申请号：US285977
申请日：1994-08-04
申请人： Evan C. Unger
发明人： Evan C. Unger
CPC分类号： G01R33/5601 , A61K49/0414 , A61K49/18 , A61K49/1803 , A61K49/1806 , A61K49/1845 , A61K49/1857 , A61K49/1863 , A61K49/226 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A contrast medium useful for diagnostic imaging is provided. The contrast medium comprises gel particles, preferably of less than about 90.mu. in mean diameter, the gel particles comprising at least one polymer entrapping at least one contrast enhancing metal.
摘要翻译： 提供了可用于诊断成像的造影剂。 造影剂包括凝胶颗粒，优选平均直径小于约90微米，凝胶颗粒包含截留至少一种对比度增强金属的至少一种聚合物。
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6.发明授权Treated calcium/oxyanion-containing particles for medical diagnostic imaging 失效用于医学诊断成像的经处理的含钙/含氧阴离子颗粒
公开(公告)号：US5407659A
公开(公告)日：1995-04-18
申请号：US47129
申请日：1993-04-13
申请人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B8/00 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K51/12 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , G01R33/28
CPC分类号： A61K51/1241 , A61K47/48861 , A61K49/0414 , A61K49/1818 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , G01R33/281 , Y10S977/722 , Y10S977/881 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。
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7.发明授权
公开(公告)号：US5358702A
公开(公告)日：1994-10-25
申请号：US62325
申请日：1993-05-14
申请人： Evan C. Unger
发明人： Evan C. Unger
CPC分类号： G01R33/5601 , A61K49/0414 , A61K49/18 , A61K49/1803 , A61K49/1806 , A61K49/1845 , A61K49/1857 , A61K49/1863 , A61K49/226 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A contrast medium useful for diagnostic imaging is provided. The contrast medium comprises gel particles, preferably of less than about 90.mu. in mean diameter, the gel particles comprising at least one polymer entrapping at least one contrast enhancing metal.
摘要翻译： 提供了可用于诊断成像的造影剂。 造影剂包括凝胶颗粒，优选平均直径小于约90微米，凝胶颗粒包含截留至少一种对比度增强金属的至少一种聚合物。
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公开(公告)号：US20160000939A1
公开(公告)日：2016-01-07
申请号：US14789584
申请日：2015-07-01
CPC分类号： A61K49/0414 , A61B6/032 , A61B6/145 , A61B6/466 , A61B6/481
摘要： Dental contrast formulations (“fillers”) of tailorable X-Ray radiopacity and methods for their use are provided. The disclosed fillers include mixtures of solid particles suspended in a biocompatible fluid. The solid particles contain one or more X-ray radiopaque materials. The biocompatible fluid can also contain one or more soluble X-ray radiopaque components. By controlling the composition of the solid particles, the composition of the biocompatible fluid, and the loading of the solid particles in the biocompatible fluid, the X-ray radiopacity and stability of the filler can be tailored to allow for improved discrimination of the filler within periodontal pockets, relative to adjacent soft tissue and teeth, so that the 3-D shape, volume, and depth of the pocket can be precisely and rapidly determined by X-Ray imaging.
摘要翻译： 提供了可裁剪的X射线辐射不透性的牙齿对比剂（“填料”）及其使用方法。 所公开的填料包括悬浮在生物相容性流体中的固体颗粒的混合物。 固体颗粒含有一种或多种X射线不透射线材料。 生物相容性流体还可以含有一种或多种可溶性X射线不透射线组分。 通过控制固体颗粒的组成，生物相容性流体的组成和固体颗粒在生物相容性流体中的负载，可以调整X射线辐射不透性和填充剂的稳定性，以便改进填料对 相对于相邻的软组织和牙齿的牙周袋，使得口袋的3-D形状，体积和深度可以通过X射线成像精确且快速地确定。
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公开(公告)号：US20150139913A1
公开(公告)日：2015-05-21
申请号：US14405489
申请日：2013-05-29
IPC分类号： A61K49/04
CPC分类号： A61K49/0419 , A61K49/0414
摘要： The present invention describes particles of titanium, titanium alloy, at least one type of titanium oxide or a combination thereof, wherein at least a substantial amount of the particles are of micrometer-millimeter size and are non-spherical, for use as an X-ray contrast agent. The irregular shapes and/or internal pores and cavities of said particles lead to a prolonged retention time in the gastrointestinal tract leading to a longer time period available for X-ray examination. Further, the particles are not only chemically inert, they also exhibit an anti-inflammatory and anti-bacterial effect on the surrounding tissue.
摘要翻译： 本发明描述了钛，钛合金，至少一种类型的氧化钛或其组合的颗粒，其中至少大量的颗粒是微米大小并且是非球形的，用作X- 射线造影剂。 所述颗粒的不规则形状和/或内部孔和空腔导致在胃肠道中延长的保留时间，导致可用于X射线检查的较长时间段。 此外，颗粒不仅是化学惰性的，它们还对周围组织表现出抗炎和抗细菌作用。
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10.发明授权Magnetically guidable carriers and methods for the targeted magnetic delivery of substances in the body 失效磁性引导载体和方法，用于靶向物质在体内的磁性传递公开(公告)号：US07189198B2
公开(公告)日：2007-03-13
申请号：US10613921
申请日：2003-07-03
申请人： Jonathan Harburn , Rogers C. Ritter
发明人： Jonathan Harburn , Rogers C. Ritter
IPC分类号： A61N2/00
CPC分类号： A61K9/0009 , A61K9/5094 , A61K49/0414 , A61M25/0127
摘要： A method of delivering a substance to targeted tissue comprising the steps of: delivering a plurality of magnetically responsive particles which are carrying the substance and have a hydrophobic coating into the patient's vasculature upstream of the targeted tissue; and applying a magnetic gradient in the vicinity of the targeted tissue to draw the magnetically responsive particles against the wall of the patient's vasculature in the vicinity of the targeted tissue, to allow the substance on the magnetic particles to migrate through the wall of the patent's vasculature to targeted tissue.
摘要翻译： 将物质递送到目标组织的方法，包括以下步骤：递送多个磁性响应颗粒，所述颗粒携带物质并且在目标组织上游的患者血管中具有疏水性涂层; 并且在目标组织附近施加磁梯度以将磁性响应颗粒吸引在靶组织附近的患者脉管系统的壁上，以允许磁性颗粒上的物质通过专利脉管系统的壁移动 到目标组织。
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