公开(公告)号：US20190231704A1

公开(公告)日：2019-08-01

申请号：US16336453

申请日：2017-08-22

申请人： Yale University ,  UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： Tarek Fahmy ,  Terrence C. Town ,  Tara M. Weitz

IPC分类号： A61K9/51 ,  A61K9/127 ,  A61K47/69 ,  A61K47/68 ,  A61K49/18 ,  A61P25/28 ,  A61K31/4439

CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/4439 ,  A61K47/02 ,  A61K47/6849 ,  A61K47/6937 ,  A61K49/1827 ,  A61P25/28

摘要： Negatively charged nanoparticulate compositions are used to deliver therapeutic, prophylactic or diagnostic agents to macrophages or other phagocytic cells in the brain and central nervous system. The negative charge of the nanoparticles increases circulation, increases internalization by macrophage or other phagocytic cells, increases release within the macrophage or other phagocytic cells, or a combination thereof, relative to charge-neutral or charge-positive nanoparticles.

公开(公告)号：US20170360965A1

公开(公告)日：2017-12-21

申请号：US15668209

申请日：2017-08-03

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Heike E. Daldrup-Link

IPC分类号： A61K49/18 ,  C01G49/00 ,  A61N5/10 ,  C09K9/02 ,  A61K39/39

CPC分类号： A61K49/1827 ,  A61K9/0019 ,  A61K9/143 ,  A61K33/26 ,  A61K39/39 ,  A61K47/6923 ,  A61N5/10 ,  C01G49/0018 ,  C09K9/02

摘要： An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle is administered to a tumor. Once the composition has been administered, it is recommended to avoid any means that would cause direct cytotoxic effects to the cancer cells and to normal/healthy tissue. The combination of composition-administered cancer cells with the avoidance of direct cytotoxic effects has been shown to be successful to inhibit the growth of the cancer cells or result in aptosis of the cancer cells. Additional dose(s) can be administered when it is determined that: (i) the tumor starts to grow and/or (ii) the remaining composition falls below a threshold. The immuno-therapy method is a safe, clinically applicable, ready-to-use theranostic approach for cancer patients who are unable to start chemoradiotherapy in a timely manner, i.e. an effective interim or adjunctive treatment for patients.

公开(公告)号：US20170216464A1

公开(公告)日：2017-08-03

申请号：US15500691

申请日：2015-07-30

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： Jin Xie ,  Hongmin Chen ,  Geoffrey D. Wang

IPC分类号： A61K49/18 ,  A61B5/055 ,  G01R33/56 ,  A61B5/00

CPC分类号： A61K49/1866 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/055 ,  A61K49/1827 ,  G01R33/5601

摘要： Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.

公开(公告)号：US20140079644A1

公开(公告)日：2014-03-20

申请号：US14083941

申请日：2013-11-19

申请人： ONTARIO INSTITUTE FOR CANCER RESEARCH

发明人： Shyh-Dar Li ,  Mark John Ernsting ,  Wei-Lun Tang

IPC分类号： A61K9/14 ,  A61K31/4745 ,  A61K49/18 ,  A61K31/337

CPC分类号： A61K9/146 ,  A61K9/5161 ,  A61K31/337 ,  A61K31/4745 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6935 ,  A61K47/6939 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/1827 ,  A61K49/186 ,  A61K49/1863 ,  C08B3/06 ,  C08B11/12 ,  C08B13/00 ,  C08B15/005 ,  C08G65/329 ,  C08G81/00 ,  C08G2261/126 ,  C08L1/286 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/05 ,  Y10T428/2982 ,  C08L1/08

摘要： In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.

摘要翻译： 在一个方面，提供了包含共价连接到：至少一种聚（乙二醇）（PEG）和至少一种疏水性药物的乙酰化羧甲基纤维素（CMC-Ac）的化合物。 另一方面，提供了包含这些化合物的自组装纳米颗粒组合物。

公开(公告)号：US20130309702A1

公开(公告)日：2013-11-21

申请号：US13982819

申请日：2012-01-31

申请人： Young Keun Kim ,  Jun Hua Wu ,  Ji Hyun Min ,  Ji-Sung Lee ,  Jae-Ho Jung

发明人： Young Keun Kim ,  Jun Hua Wu ,  Ji Hyun Min ,  Ji-Sung Lee ,  Jae-Ho Jung

IPC分类号： G01N27/72

CPC分类号： G01N27/72 ,  A61K49/1827 ,  A61K49/1851 ,  A61K49/1866 ,  A61K49/1875 ,  C01G45/12 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/04 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/42 ,  G01N33/587

摘要： The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0 degrees centigrade to 41 degrees centigrade, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention can minimize adverse effects of ferromagnetic properties thereof, and can be used in the effective detection and separation of biological control agents.

摘要翻译： 本发明涉及具有在生物相容性温度范围内的居里温度的磁性纳米颗粒，其制备方法以及包含该磁性纳米颗粒的纳米复合材料和目标物质检测组合物。 由于本发明的磁性纳米颗粒的居里温度在0摄氏度到41摄氏度的温度范围内，磁性纳米颗粒的铁磁性和顺磁性能可以在生物相容性温度范围内控制， 试剂不被破坏，并且调节磁性纳米颗粒的温度以控制其磁性，使得仅当需要铁磁性质时才能使用磁性纳米颗粒的性质，例如在检测，分离中的信号放大的情况下 ，并提供生物控制剂。 因此，本发明的磁性纳米颗粒可以使其铁磁性能的不利影响最小化，并可用于生物控制剂的有效检测和分离。

公开(公告)号：US20130164223A1

公开(公告)日：2013-06-27

申请号：US13819525

申请日：2011-08-30

申请人： Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

发明人： Bong-Sik Jeon ,  Eung Gyu Kim ,  Eun Byul Kwon ,  Ju Young Park ,  Wan Jae Myeong

IPC分类号： A61K49/18

CPC分类号： A61K49/1893 ,  A61K49/1824 ,  A61K49/1827 ,  A61K49/1839 ,  A61K49/1857 ,  A61K49/1887

摘要： Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5≦100*Dμ(IO)/C ω(IO)  [Relation 1] 2.5≦100*Dμ(Cap)/C ω(Cap)  [Relation 2] 0.5 wt %≦F(IO)≦50 wt %  [Relation 3] 1 nm≦Dμ(IO)≦25 nm  [Relation 4] 50 nm≦Dμ(Cap)≦200 nm  [Relation 5]

摘要翻译： 本发明提供一种具有高对比度的MRI造影剂的氧化铁纳米胶囊，其中附着有疏水性配体的多种氧化铁纳米粒子被包封在包含可生物降解的聚合物和表面活性剂的包封材料中，并且满足关系1,2， 3，4和5。 还提供了一种制造氧化铁纳米胶囊的方法。 5 @ 100 * Dmu（IO）/Cω（IO）[关系1] 2.5×100×Dmu（Cap）/Cω（Cap）[关系2] 0.5wt％@ F（IO）@ 50wt％ 3] 1nm @ Dmu（IO）@ 25nm [关系4] 50nm @ Dmu（Cap）@ 200nm [关系5]

公开(公告)号：US20110150777A1

公开(公告)日：2011-06-23

申请号：US12968310

申请日：2010-12-15

申请人： Sebastian Schmidt

发明人： Sebastian Schmidt

IPC分类号： A61K49/06 ,  C07F19/00 ,  C07C19/08 ,  C08B11/02 ,  C08B31/10 ,  A61P43/00 ,  C22C38/00

CPC分类号： A61K49/105 ,  A61B5/055 ,  A61K49/10 ,  A61K49/18 ,  A61K49/1827 ,  B82Y5/00

摘要： A medical magnetic resonance tomography apparatus and a contrast agent for magnetic resonance tomography imaging of cavities in a patient are provided. The contrast agent is formed from a highly viscous magnetic resonance contrast agent. The highly viscous magnetic resonance contrast agent includes a substance. A specific magnetic resonance contrast can be generated by the substance.

摘要翻译： 提供了一种医用磁共振断层摄影装置和用于病人空腔的磁共振层析成像的造影剂。 造影剂由高粘度磁共振造影剂形成。 高粘度磁共振造影剂包括物质。 物质可以产生特定的磁共振对比度。

公开(公告)号：US20240117315A1

公开(公告)日：2024-04-11

申请号：US18331353

申请日：2023-06-08

申请人： Mesoblast International Sárl

发明人： Samson TOM ,  Christopher TON ,  Alla DANILKOVITCH

IPC分类号： C12N5/0775 ,  A61K35/28 ,  A61K41/00 ,  A61K47/69 ,  A61K49/04 ,  A61K49/18 ,  B82Y5/00

CPC分类号： C12N5/0663 ,  A61K35/28 ,  A61K41/0038 ,  A61K41/0052 ,  A61K47/6901 ,  A61K49/0423 ,  A61K49/1827 ,  B82Y5/00 ,  A61M37/00 ,  C12N2511/00

摘要： The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least about 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryopreserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof.

公开(公告)号：US10016522B2

公开(公告)日：2018-07-10

申请号：US14424689

申请日：2013-08-27

申请人： Carlo Bulletti

发明人： Francesco Maria Bulletti

IPC分类号： A61K51/12 ,  A61K49/00 ,  A61K49/18 ,  A61K49/10

CPC分类号： A61K51/1244 ,  A61K49/0021 ,  A61K49/003 ,  A61K49/0093 ,  A61K49/10 ,  A61K49/1827

摘要： A vaginal preparation for the diagnosis of human female uterotubal patency and function, comprising particles having a nucleus absorbable by the tissues of the human body, and a coating for the nucleus which is dissolvable and non-absorbable by the tissues of the human body, inert and innocuous, the nucleus comprising at least one marker that can be released by the human body through an organic fluid, the coating being dissolvable and sensitive, for the purpose of the dissolution thereof, to time and/or changes in pH and/or temperature and/or another chemical/physical parameter along the route from the vaginal area to the tubal and pelvic area, the particles having a size, weight and ovoid shape corresponding approximately to those of spermatozoa.

公开(公告)号：US20180003676A1

公开(公告)日：2018-01-04

申请号：US15702062

申请日：2017-09-12

申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

发明人： Young Keun KIM ,  Jun Hua WU ,  Ji Hyun MIN ,  Ji-Sung LEE ,  Jae-Ho JUNG

IPC分类号： G01N27/72 ,  C01G45/12 ,  G01N33/58 ,  A61K49/18

CPC分类号： G01N27/72 ,  A61K49/1827 ,  A61K49/1851 ,  A61K49/1866 ,  A61K49/1875 ,  C01G45/12 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/04 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/42 ,  G01N33/587

摘要： The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within the temperature range of 0 degrees centigrade to 41 degrees centigrade, the ferromagnetic and paramagnetic properties of the magnetic nanoparticle may be controlled within a biocompatible temperature range at a temperature at which a biological control agent is not destroyed, and the temperature of the magnetic nanoparticle is adjusted to control the magnetic properties thereof such that the properties of the magnetic nanoparticle may be used only when ferromagnetic properties are required, such as in the case of signal amplification in detecting, separating, and delivering biological control agents. Accordingly, the magnetic nanoparticle of the present invention can minimize adverse effects of ferromagnetic properties thereof, and can be used in the effective detection and separation of biological control agents.