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公开(公告)号：US06428768B1
公开(公告)日：2002-08-06
申请号：US08442252
申请日：1995-05-15
IPC分类号： A61K5100
CPC分类号： A61K51/1282 , A61K2121/00
摘要： The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
摘要翻译： 本发明涉及放射性药物制剂的稳定化和放射性药物试剂盒组分的稳定化。 特别地，本发明涉及通过向试剂盒中加入环状寡糖例如改性或未改性的环糊精来稳定放射性药物试剂盒的冻干组分。
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公开(公告)号：US5651956A
公开(公告)日：1997-07-29
申请号：US582781
申请日：1996-01-04
CPC分类号： B82Y5/00 , A61K49/0428 , A61K49/183 , A61K49/22 , Y10T436/24
摘要： The present invention provides new and structurally diverse particulates for use in magnetic resonance imaging and X-ray contrast imaging of body organs and tissues having the following general formula:Ca.sub.n M.sub.m X.sub.r Y.sub.swherein M is a paramagnetic ion or stoichiometric mixture of metal ions having a valence of 2+ or 3+; X is a simple anion; Y is a tetrahedral oxyanion, or mixtures thereof; m is an integer greater than or equal to 1; n is an integer greater than or equal to 1; r and s are integers and are adjusted as needed to provide charge neutrality; and further comprising a polyalkoxy compound.Methods for using and making particles of the invention are also disclosed.
摘要翻译： 本发明提供用于磁共振成像和身体器官和组织的X射线对比成像的新的和结构上不同的微粒，具有以下通式：其中M是顺磁离子或化学计量混合物的化学计量混合物，其具有2价 +或3+; X是简单的阴离子; Y是四面体氧阴离子，或其混合物; m是大于或等于1的整数; n是大于或等于1的整数; r和s是整数，并根据需要进行调整以提供电荷中性; 并且还包含聚烷氧基化合物。 还公开了使用和制造本发明颗粒的方法。
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公开(公告)号：US5609850A
公开(公告)日：1997-03-11
申请号：US518124
申请日：1995-08-22
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , A61B8/13
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了处理的磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的基础诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后执行医学诊断程序。
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4.发明授权Treated calcium/oxyanion-containing particles for medical diagnostic imaging 失效用于医学诊断成像的经处理的含钙/含氧阴离子颗粒
公开(公告)号：US5595724A
公开(公告)日：1997-01-21
申请号：US373152
申请日：1995-01-13
申请人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe , William P. Cacheris , Linda Meeh
发明人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe , William P. Cacheris , Linda Meeh
IPC分类号： A61B5/055 , A61B8/00 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K51/12 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , G01R33/28
CPC分类号： A61K51/1241 , A61K47/48861 , A61K49/0414 , A61K49/1818 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , G01R33/281 , Y10S977/722 , Y10S977/881 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。
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公开(公告)号：US5344640A
公开(公告)日：1994-09-06
申请号：US948540
申请日：1992-09-22
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了治疗磷灰石颗粒用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后进行医学诊断程序。
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公开(公告)号：US5037631A
公开(公告)日：1991-08-06
申请号：US605640
申请日：1990-10-29
申请人： Dennis L. Nosco
发明人： Dennis L. Nosco
CPC分类号： C07F13/005 , A61K51/0478
摘要： The present invention relates to novel technetium-99m complexes and to methods of preparaing the complexes. The present invention further relates to radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.
摘要翻译： 本发明涉及新型锝-99m络合物和制备复合物的方法。 本发明还涉及包含复合物的放射性药物组合物，用于检查肾功能的组合物，以及用于制备这些组合物的试剂盒。
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公开(公告)号：US5908931A
公开(公告)日：1999-06-01
申请号：US627175
申请日：1990-12-14
IPC分类号： A61K51/00 , A61K51/04 , C07C215/14 , C07C229/12 , C07C323/25 , C07D213/38 , C07D231/12 , C07D233/64 , C07D261/06 , C07D263/30 , C07D277/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/50 , C07F9/72 , C07F13/00 , C07F9/80 , C07D221/02 , C07D221/16 , C07F9/06
CPC分类号： C07C215/14 , A61K51/0478 , A61K2123/00
摘要： The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for completing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
摘要翻译： 本发明特别涉及适用于用放射性核素完成的新型预组织六齿配体，并且可用作用于诊断目的的一般成像剂。
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公开(公告)号：US5648060A
公开(公告)日：1997-07-15
申请号：US452470
申请日：1995-05-26
IPC分类号： A61K51/00 , A61K51/04 , C07C215/14 , C07C229/12 , C07C323/25 , C07D213/38 , C07D231/12 , C07D233/64 , C07D261/06 , C07D263/30 , C07D277/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/50 , C07F9/72 , C07F13/00 , C07F5/00
CPC分类号： C07C215/14 , A61K51/0478 , A61K2123/00
摘要： The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
摘要翻译： 本发明特别涉及适用于与放射性核素络合的新型预组织六齿配体，并且可用作用于诊断目的的一般成像剂。
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9.发明授权Treated calcium/oxyanion-containing particles for medical diagnostic imaging 失效用于医学诊断成像的经处理的含钙/含氧阴离子颗粒
公开(公告)号：US5407659A
公开(公告)日：1995-04-18
申请号：US47129
申请日：1993-04-13
申请人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B8/00 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K51/12 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , G01R33/28
CPC分类号： A61K51/1241 , A61K47/48861 , A61K49/0414 , A61K49/1818 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , G01R33/281 , Y10S977/722 , Y10S977/881 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。
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公开(公告)号：US5320824A
公开(公告)日：1994-06-14
申请号：US47322
申请日：1993-04-16
CPC分类号： A61K51/1241 , A61K51/1255 , A61K2121/00
摘要： The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.
摘要翻译： 本发明提供了用于治疗发炎滑膜的放射性滑膜切除组合物，该组合物含有与实质上不溶性颗粒结合的放射性核素复合物作为放射性标记的滑膜切除剂，其量足以使得发炎的滑膜与药学上可接受的载体一起提供令人满意的滑膜切除术，放射性核素为β 发射器将基本上消融发炎的滑膜，但不显着损伤关节软骨，放射性核素复合物基本上是动态稳定的，并且如果所述放射性核素或放射性核素复合物从所述接头泄漏，则其将从体内排出， 使得放射性核素复合物在给药后几乎几乎没有或没有从关节泄漏。
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