公开(公告)号：US20180169159A1

公开(公告)日：2018-06-21

申请号：US15735502

申请日：2016-06-13

Applicant: UNIVERSITY OF MIAMI

Inventor： Glen N. Barber

IPC: A61K35/763 ,  A61P35/00 ,  G01N33/574

CPC classification number: A61K35/763 ,  A61P35/00 ,  C12N2710/16633 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2333/4706

Abstract: The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of STING or cGAS in the cell; and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.

公开(公告)号：US20170340731A1

公开(公告)日：2017-11-30

申请号：US15681393

申请日：2017-08-20

Applicant: Squarex, LLC

Inventor： Hugh McTavish

IPC: A61K39/245 ,  A61K35/763 ,  G01N33/571 ,  C07K14/035 ,  A61K39/00

CPC classification number: A61K39/245 ,  A61K31/04 ,  A61K35/763 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55511 ,  C07K14/035 ,  C12N2710/16611 ,  G01N33/571

Abstract: A method is presented for treating herpes simplex virus (HSV) infection comprising: (a) locally administering a substance that induces a delayed type hypersensitivity (DTH) response to a patient at a site of an HSV lesion to induce a DTH response at the site of the lesion during one or more outbreaks of the HSV infection.

公开(公告)号：US20170319639A1

公开(公告)日：2017-11-09

申请号：US15588616

申请日：2017-05-06

Applicant: William Jia

Inventor： William Jia

IPC: A61K35/763 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K35/763 ,  A61K38/00 ,  A61P35/00 ,  C07K14/005 ,  C07K14/54 ,  C07K14/555 ,  C07K14/705 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/73 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16643 ,  C12N2830/008

Abstract: Modified and improved oncolytic viruses (and methods of use thereof) are disclosed. More particularly, modified and oncolytic human herpesviruses (and methods of use thereof) are disclosed, which include a modified amino acid sequence that includes a deletion in a region that represents the amino terminus of glycoprotein K. The modified and oncolytic human herpesviruses include a deletion of amino acid residues 31-68, relative to the wild type amino acid sequence of glycoprotein K in human herpesviruses. Isolated vector constructs that encode such oncolytic viruses are also disclosed. In addition, methods for using such oncolytic viruses to treat cancers are disclosed.

公开(公告)号：US09744199B2

公开(公告)日：2017-08-29

申请号：US14864098

申请日：2015-09-24

Applicant: ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA

Inventor： Gabriella Campadelli ,  Laura Menotti

IPC: A61K35/00 ,  A61K35/76 ,  A61K49/04 ,  C07K14/005 ,  C12N7/00 ,  A61K39/245 ,  C07K14/035 ,  A61K35/763

CPC classification number: A61K35/763 ,  A61K49/04 ,  C07K14/005 ,  C07K2317/622 ,  C07K2319/33 ,  C07K2319/61 ,  C07K2319/74 ,  C12N7/00 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16633 ,  C12N2710/16651 ,  C12N2710/16722 ,  C12N2810/85 ,  Y02A50/407

Abstract: A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

公开(公告)号：US20170071991A1

公开(公告)日：2017-03-16

申请号：US15310556

申请日：2015-05-07

Applicant: VIRTTU BIOLOGICS LIMITED

Inventor： Joe Conner

IPC: A61K35/763 ,  A61K31/55 ,  C12N7/00

CPC classification number: A61K35/763 ,  A61K31/55 ,  A61K45/06 ,  C12N7/00 ,  C12N2710/16632 ,  A61K2300/00

Abstract: The use of an oncolytic virus and an aurora kinase inhibitor in the treatment of cancer is disclosed.

Abstract translation: 公开了使用溶瘤病毒和极光激酶抑制剂治疗癌症。

公开(公告)号：US09580699B2

公开(公告)日：2017-02-28

申请号：US14690038

申请日：2015-04-17

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： William F. Goins ,  Joseph C. Glorioso, III ,  Justus Bernhard Cohen ,  Bonnie L. Reinhart

IPC: A61K35/763 ,  C12N9/16 ,  C07K14/47 ,  A61K38/46 ,  A61K48/00 ,  A61K9/00 ,  A61K47/02 ,  A61K9/08

CPC classification number: C12N9/16 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08 ,  A61K38/46 ,  A61K47/02 ,  A61K48/005 ,  C07K14/4703 ,  C12N2710/16643 ,  C12N2799/028 ,  C12N2830/008

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.

Abstract translation: 本发明提供一种通过在神经元中表达PP1α来改善涉及瞬时受体电位阳离子通道亚族V成员1（TRPV1）的慢性疼痛信号的方法。 本发明还提供了用于在神经元内表达PP1α的HSV载体和包含这种载体的组合物。

公开(公告)号：US20170035819A1

公开(公告)日：2017-02-09

申请号：US15204350

申请日：2016-07-07

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Hiroaki Uchida ,  Justus B. Cohen ,  Joseph C. Glorioso, III ,  Paola Grandi

IPC: A61K35/763 ,  C12N7/00

CPC classification number: A61K35/763 ,  C07K14/005 ,  C07K2319/33 ,  C12N7/00 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16641 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2710/16662 ,  C12N2710/16671

Abstract: The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Abstract translation: 本发明提供了一种重组溶瘤性单纯疱疹病毒（oHSV），其包含对细胞（例如癌细胞）表面上存在的分子（蛋白质，脂质或碳水化合物决定簇）特异的非HSV配体和一种或多种 插入到一个或多个HSV基因座中的一个或多个microRNA靶序列的拷贝，优选在正常（即非癌性）细胞中HSV复制所需的一种或多种HSV基因。 本发明还提供了包含本发明的oHSV的库存和药物组合物以及使用本发明的oHSV杀死肿瘤细胞的方法。

公开(公告)号：US20160030567A1

公开(公告)日：2016-02-04

申请号：US14450686

申请日：2014-08-04

Applicant: Carolyn Blakeslee

Inventor： Carolyn Blakeslee

IPC: A61K47/02 ,  A61K33/10 ,  A61K35/24 ,  A61K36/38 ,  A61K36/83 ,  A61K36/22 ,  A61K36/28 ,  A61K35/763

CPC classification number: A61K47/02 ,  A61K9/0014 ,  A61K9/10 ,  A61K33/06 ,  A61K35/612 ,  A61K35/76 ,  A61K35/763 ,  A61K36/22 ,  A61K36/28 ,  A61K36/38 ,  A61K36/83 ,  A61K41/0004 ,  A61K49/0002 ,  A61K2300/00

Abstract: The present invention relates to a topical homeopathic remedy for skin conditions generally known as dermatitis. The present invention further relates to a composition forming said topical homeopathic remedy, a process for creating such composition and a method of using same. The present invention may comprise a combination of at least one of the following compounds: arnica montana, calcarea carbonica, calendula officinalis, herpes zoster, hypericum, mezereum, rhus toxicodendron, and variolinum, polymerized in a mixture of calcium montmorillonite and water.

Abstract translation: 本发明涉及通常称为皮炎的皮肤病症的局部顺势疗法。 本发明还涉及形成所述局部顺势疗法药物的组合物，制备该组合物的方法及其使用方法。 本发明可以包含以下化合物中的至少一种的化合物：在蒙脱石钙和水混合物中聚合的山茱萸蒙大拿，碳酸钙，金盏花，带状疱疹，金丝桃，梅毒，根毒素和变种。

公开(公告)号：US20150374767A1

公开(公告)日：2015-12-31

申请号：US14768549

申请日：2014-02-21

Applicant: VIRTTU BIOLOGICS LIMITED

Inventor： Joe CONNER

IPC: A61K35/763 ,  G01N33/50 ,  A61K45/06

CPC classification number: A61K35/763 ,  A61K39/00 ,  A61K45/06 ,  A61K2039/525 ,  C07K14/005 ,  C07K14/52 ,  C07K14/5434 ,  C07K14/70578 ,  C12N2710/16641 ,  C12N2710/16643 ,  C12N2710/16645 ,  C12N2710/16662 ,  C12N2710/16671 ,  G01N33/5011 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

Abstract: A method of treating cancer is disclosed, the method comprising simultaneous or sequential administration of a virus and a receptor tyrosine kinase (RTK) inhibitor.

Abstract translation: 公开了一种治疗癌症的方法，所述方法包括同时或顺序施用病毒和受体酪氨酸激酶（RTK）抑制剂。

公开(公告)号：US20150297649A1

公开(公告)日：2015-10-22

申请号：US14690038

申请日：2015-04-17

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： William F. Goins ,  Joseph C. Glorioso, III ,  Justus Bernhard Cohen ,  Bonnie L. Reinhart

IPC: A61K35/763 ,  C12N7/00 ,  A61K9/00 ,  C12N15/86 ,  C12N9/16

CPC classification number: C12N9/16 ,  A61K9/0019 ,  A61K9/0085 ,  A61K9/08 ,  A61K38/46 ,  A61K47/02 ,  A61K48/005 ,  C07K14/4703 ,  C12N2710/16643 ,  C12N2799/028 ,  C12N2830/008

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.

Abstract translation: 本发明提供一种通过在神经元中表达PP1α来改善涉及瞬时受体电位阳离子通道亚族V成员1（TRPV1）的慢性疼痛信号的方法。 本发明还提供了用于在神经元内表达PP1α的HSV载体和包含这种载体的组合物。