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公开(公告)号：US10201575B2
公开(公告)日：2019-02-12
申请号：US15032958
申请日：2014-10-28
IPC分类号： C12N15/00 , A61K48/00 , A61K35/763 , C12N7/00 , C07K14/005
摘要： The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and a plurality of copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells, and a deletion of the internal repeat (joint) region in the HSV genome comprising one copy of the ICP0, ICP34.5, LAT, and ICP4 genes and the ICP47 promoter. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
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公开(公告)号：US10172893B2
公开(公告)日：2019-01-08
申请号：US15616585
申请日：2017-06-07
IPC分类号： C12N15/00 , A61K35/763 , C12N7/00 , C07K14/005
摘要： The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
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公开(公告)号：US20170189514A1
公开(公告)日：2017-07-06
申请号：US15409245
申请日：2017-01-18
CPC分类号： A61K39/0011 , A61K2039/585 , C07K14/005 , C12N7/00 , C12N15/86 , C12N15/8695 , C12N2710/16621 , C12N2710/16622 , C12N2710/16643 , C12N2710/16671 , C12N2810/6009 , C12N2810/851 , C12N2810/859
摘要： In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
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公开(公告)号：US11419926B2
公开(公告)日：2022-08-23
申请号：US16417254
申请日：2019-05-20
IPC分类号： A61K35/763 , C12N15/869 , C12N15/38 , A61K48/00 , A61K35/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N15/86
摘要： In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
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公开(公告)号：US20200147189A1
公开(公告)日：2020-05-14
申请号：US16417254
申请日：2019-05-20
IPC分类号： A61K39/00 , C12N15/869 , C12N15/86 , C12N7/00 , C07K14/005
摘要： In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
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公开(公告)号：US10576115B2
公开(公告)日：2020-03-03
申请号：US16191141
申请日：2018-11-14
IPC分类号： C12N15/00 , A61K35/763 , C12N7/00 , C07K14/005
摘要： The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
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公开(公告)号：US20190262410A1
公开(公告)日：2019-08-29
申请号：US16191141
申请日：2018-11-14
IPC分类号： A61K35/763 , C07K14/005 , C12N7/00
摘要： The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
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公开(公告)号：US10188686B2
公开(公告)日：2019-01-29
申请号：US15204350
申请日：2016-07-07
IPC分类号： C12N15/00 , A61K48/00 , A61K35/763 , C12N7/00 , C07K14/005
摘要： The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
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公开(公告)号：US10328136B2
公开(公告)日：2019-06-25
申请号：US15409245
申请日：2017-01-18
IPC分类号： C12N15/869 , C12N7/01 , A61K48/00 , A61K35/763 , A61K39/00 , C07K14/005 , C12N7/00 , C12N15/86
摘要： In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
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公开(公告)号：US11883448B2
公开(公告)日：2024-01-30
申请号：US16985459
申请日：2020-08-05
IPC分类号： C12N15/00 , A61K35/763 , C12N7/00 , C07K14/005
CPC分类号： A61K35/763 , C07K14/005 , C12N7/00 , C07K2319/33 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16641 , C12N2710/16643 , C12N2710/16645 , C12N2710/16662 , C12N2710/16671
摘要： The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
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