公开(公告)号：US06354989B1

公开(公告)日：2002-03-12

申请号：US09416938

申请日：1999-10-13

申请人： Masahiro Nudeshima

发明人： Masahiro Nudeshima

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61N2005/1023 ,  A61N2005/1025

摘要： A radiation source delivery wire has a flexible operating wire member, and an irradiation member including a radiation source for applying radiation to a target portion in a cavity of a living body. The irradiation member including the radiation source is so constructed as to be flexibly bendable, and a distal end portion of the operating wire member constitutes a narrowing portion which gradually narrows toward its distal end.

摘要翻译： 辐射源输送线具有柔性的操作线构件，以及包括用于向生物体的空腔中的目标部分施加辐射的辐射源的照射构件。 包括辐射源的照射构件被构造成可弯曲的，并且操作线构件的远端部分构成朝向其远端逐渐变窄的变窄部分。

公开(公告)号：US06315708B1

公开(公告)日：2001-11-13

申请号：US09540629

申请日：2000-03-31

申请人： Sean Salmon ,  Dieter Stockel ,  Robert E. Fischell ,  Tim A. Fischell ,  David R. Fischell

发明人： Sean Salmon ,  Dieter Stockel ,  Robert E. Fischell ,  Tim A. Fischell ,  David R. Fischell

IPC分类号： A61N500

CPC分类号： A61F2/958 ,  A61F2/90 ,  A61F2002/9583 ,  A61F2250/0018 ,  A61F2250/0042 ,  A61F2250/0048

摘要： The present invention is a hybrid stent that is defined as having a central section that is balloon expandable and end sections that are self-expanding. The entire stent is mounted on a balloon of a balloon angioplasty catheter. One way to retain the self-expanding portion of the stent onto a balloon onto which it has been nested is to place a cylindrical elastomer tube around each of the self-expanding end sections of the stent. Another way to retain the hybrid stent onto a stent delivery system is to use a conventional sheath that is pulled back to initiate stent deployment

摘要翻译： 本发明是一种混合型支架，其被定义为具有球囊可膨胀的中心部分和自膨胀的端部。 整个支架安装在球囊血管成形术导管的球囊上。 将支架的自膨胀部分保持在其已经嵌套在其上的气球上的一种方法是将圆柱形弹性体管围绕在支架的每个自扩张端部分上。 将混合支架保持在支架输送系统上的另一种方法是使用被拉回以启动支架部署的常规护套

公开(公告)号：US06312375B1

公开(公告)日：2001-11-06

申请号：US09368557

申请日：1999-08-05

申请人： Joseph F. Montebello ,  Robert T. Woodburn, III

发明人： Joseph F. Montebello ,  Robert T. Woodburn, III

IPC分类号： A61N500

CPC分类号： A61N5/1016

摘要： An apparatus for use in optimizing radiation dose distributions to a rectum and a bladder of a patient during the treatment of malignancies of female genitalia is provided in accordance with the present invention. The apparatus includes a colpostat intracavitary implant including a housing portion adapted to receive a radiation source therein and a jacket. The jacket defines a cavity sized to receive the housing portion. The jacket is configured to selectively expand in volumetric size to move the rectum and the bladder away from the radiation source.

摘要翻译： 根据本发明提供了一种用于在治疗女性生殖器恶性肿瘤期间优化对患者直肠和膀胱的辐射剂量分布的装置。 该装置包括共发射器腔内植入物，其包括适于在其中容纳辐射源的壳体部分和护套。 护套限定了尺寸设置成容纳壳体部分的腔体。 护套构造成选择性地扩大体积尺寸以使直肠和膀胱远离辐射源移动。

公开(公告)号：US06283911B1

公开(公告)日：2001-09-04

申请号：US09391054

申请日：1999-09-16

申请人： Hanan Keren

发明人： Hanan Keren

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61N2005/1003 ,  A61N2005/1023 ,  A61N2005/1025

摘要： A device for delivering radiation to at least one preselected site in a vascular system of a patient, includes an elongated flexible catheter tube of a diameter for insertion into the patient's vascular system, and a flexible guide wire within the catheter tube and movable along its length. The guide wire includes a proximal end to be located externally of the patient's vascular system for moving the guide wire within the catheter tube, and a rounded distal tip at the opposite end to facilitate movement of the guide wire through the catheter tube. At least one radiation-producing element is fixed to the guide wire at an intermediate location spaced from the rounded distal tip.

摘要翻译： 用于将辐射递送到患者血管系统中的至少一个预选部位的装置包括用于插入患者血管系统中的直径的细长柔性导管，以及导管内的柔性引导线，并可沿其长度移动 。 引导线包括位于患者血管系统外部的近端，用于移动导管内的导丝，以及在相对端的圆形远端尖端，以便于导丝通过导管的移动。 至少一个辐射产生元件在与圆形远端尖端间隔开的中间位置处固定到导丝。

公开(公告)号：US06267779B1

公开(公告)日：2001-07-31

申请号：US09281443

申请日：1999-03-29

申请人： Harold M. Gerdes

发明人： Harold M. Gerdes

IPC分类号： A61N500

CPC分类号： A61N5/0616 ,  A61N2005/0644 ,  A61N2005/0659 ,  A61N2005/067

摘要： The therapeutic laser apparatus includes at least two wands connected to a controller and radiation source via fiber optic cables. The controller and source include at least two infrared wavelength solid-state diode (“SSD”) lasers and at least two visible wavelength SSD aiming lasers. The apparatus further includes a combiner configured to maintain the electromagnetic radiation from one infrared SSD laser coincident with one visible light SSD aiming laser. In the method according to the invention, the visible light SSD aiming laser is used as a pointer so that an operator can position the wands adjacent to the skin of a mammal whereby the beams of infrared treatment lasers intersect at a region inside the body of the mammal.

摘要翻译： 治疗激光装置包括经由光纤电缆连接到控制器和辐射源的至少两个杆。 控制器和源包括至少两个红外波长固态二极管（“SSD”）激光器和至少两个可见波长的SSD瞄准激光器。 该装置还包括组合器，其被配置为保持来自一个红外SSD激光器的电磁辐射与一个可见光SSD瞄准激光器重合。 在根据本发明的方法中，可见光SSD瞄准激光器用作指针，使得操作者可以将棒定位在哺乳动物的皮肤附近，由此红外线治疗激光束在其内部的区域内相交 哺乳动物。

公开(公告)号：US06254552B1

公开(公告)日：2001-07-03

申请号：US09164730

申请日：1998-10-01

申请人： Robert E. Lewis ,  Prahlad R. Singh ,  Gerald P. Tercho ,  Paul R. Walsh

发明人： Robert E. Lewis ,  Prahlad R. Singh ,  Gerald P. Tercho ,  Paul R. Walsh

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61K51/1282 ,  A61N2005/1025 ,  Y10S977/949

摘要： An intra-coronary radiation devices containing Ce-144 or Ru-106 deposited onto a wire and coated with a biocompatible material and methods of making and using the same.

摘要翻译： 包含沉积在线上并涂覆有生物相容性材料的Ce-144或Ru-106的冠状内辐射装置及其制备和使用它们的方法。

公开(公告)号：US06248056B1

公开(公告)日：2001-06-19

申请号：US09269119

申请日：1999-03-19

申请人： Bertil Persson

发明人： Bertil Persson

IPC分类号： A61N500

CPC分类号： A61N1/326 ,  A61N5/10

摘要： An apparatus (40) according to the invention includes a radiation emitter (34) for ionizing radiation and a high voltage generator (1) for generating brief voltage pulses for voltage application of electrodes (6, 15, 16, 24) included in the apparatus. The electrodes are designed to be secured at or introduced into tissue in a restricted region of a human or an animal and to form between them an electric field in the tissue. The radiation emitter (34) is provided to emit ionizing radiation to a tumor in the tissue in that region which is to be treated, while the electrodes (6, 15, 16, 24) are disposed to be placed in or at the tumor in order that the electric field pass through the tumor.

摘要翻译： 根据本发明的装置（40）包括用于电离辐射的辐射发射器（34）和用于产生用于电压施加包括在装置中的电极（6,15,16,24）的短暂电压脉冲的高压发生器（1） 。 电极被设计成固定在人或动物的受限区域中的组织中或在其中引入组织中并且在它们之间形成组织中的电场。 辐射发射器（34）被设置为向待处理的区域中的组织中的肿瘤发射电离辐射，同时将电极（6,15,16,24）放置在放置在肿瘤中或其中的肿瘤中 命令电场通过肿瘤。

公开(公告)号：US06238332B1

公开(公告)日：2001-05-29

申请号：US09437402

申请日：1999-11-10

申请人： Nozomu Kanesaka

发明人： Nozomu Kanesaka

IPC分类号： A61N500

CPC分类号： A61N5/1002

摘要： A radiation device is used in a body lumen for treatment. The radiation device is formed of a sheath to be disposed in the body lumen, and an elongated radiation member. The sheath includes a guide wire passageway to allow a guide wire to pass therethrough, and a sheath passageway extending throughout a substantial portion thereof. The radiation member includes an outer member having a shield portion at a front part thereof, and an inner member slidably situated in the outer member and having a radiation portion at a front part thereof. When the radiation device is used, the sheath is introduced into a body lumen by sliding over the guide wire preliminary placed in the body lumen. Then, the radiation member is inserted into the sheath passageway in a condition such that the radiation portion is located inside the shielding portion. When radiation is required, the radiation portion is disposed outside the shield portion. Since the sheath prevents the radiation member from contacting the body lumen, the radiation member may be reused.

摘要翻译： 辐射装置用于体腔用于治疗。 辐射装置由待设置在体腔内的护套和细长辐射构件形成。 护套包括允许导丝通过的引导线通道，以及贯穿其主要部分延伸的护套通道。 辐射构件包括在其前部具有屏蔽部分的外部构件和可滑动地位于外部构件中并且在其前部具有辐射部分的内部构件。 当使用辐射装置时，通过在预先放置在体腔中的导丝上滑动将鞘引入体腔内。 然后，辐射构件以使得辐射部分位于屏蔽部分内的状态插入护套通道中。 当需要辐射时，辐射部分设置在屏蔽部分的外侧。 由于护套防止辐射构件接触体腔，所以辐射构件可以被再次使用。

公开(公告)号：US06224535B1

公开(公告)日：2001-05-01

申请号：US09024666

申请日：1998-02-17

申请人： Jessica G. Chiu ,  Eric D. Peterson

发明人： Jessica G. Chiu ,  Eric D. Peterson

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61M25/10 ,  A61N2005/1003

摘要： The invention is directed to a radiation delivery catheter assembly for maintaining patency of a body lumen for a period of time sufficient to allow delivery of a radiation source to the body lumen. The catheter utilizes an inflatable region which maintains and centers the catheter in the body lumen. The catheter may include a perfusion lumen for supplying oxygenated blood to tissue located downstream from the catheter when the inflatable region is expanded in the body lumen. The inflatable region can be made up of a plurality of balloon segments which help center the radiation source, even if placed on a curved section of the body lumen. Embodiments of the invention include a catheter design which utilizes “rapid exchange” features and a dual therapeutic catheter which is capable of dilating a stenosed region of the body lumen prior to the administration of the radiation treatment. A two-piece protective sheath is used to protect the radiation source from bodily fluids.

摘要翻译： 本发明涉及一种辐射递送导管组件，用于维持体腔通畅一段足以使辐射源传送至体腔的时间。 该导管使用可将导管保持并居中在体腔内的可充气区域。 当可膨胀区域在体腔内扩张时，导管可包括用于将氧合血液供应到位于导管下游的组织的灌注腔。 可膨胀区域可以由多个气囊段组成，即使放置在体腔的弯曲部分上也有助于使辐射源居中。 本发明的实施例包括利用“快速交换”特征的导管设计和能够在施用放射治疗之前扩张体腔的狭窄区域的双重治疗导管。 使用两片保护套来保护辐射源免受体液的伤害。

公开(公告)号：US06210315B1

公开(公告)日：2001-04-03

申请号：US09354073

申请日：1999-07-15

申请人： Marvin O. Andrews ,  Frank J. Fischer, Jr. ,  John H. Ward

发明人： Marvin O. Andrews ,  Frank J. Fischer, Jr. ,  John H. Ward

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1011

摘要： A brachytherapy device 10 for exposing to radioactivity a patient includes an elongate member such as a needle or cannula 12 adapted for introduction into the patient and also includes a stylet 14 slideably receivable in a longitudinal throughbore 16 in the needle 12. The device 10 also includes a portion 64 near either the proximal end 18 of the needle 12 or the distal end 24 of the stylet 14 which provides a local, defined amount of friction between the needle 12 and the stylet 14. The device 10 further includes an anti-static handle 34 connected to the needle 12. The handle 34 has an interior ramp surface 40 in communication with the throughbore 16 of the needle 12, frustoconical in shape and possessing an included apical angle of at least about 16°. The localized friction portion 64 can be a crimp or flange 48 on the stylet 14, or a crimp 44 or deformation 46 in or of the needle 12. The handle 34 is preferably composed of a polycarbonate, acrylic or acetal resin (such resins preferably being carbon-filled, or otherwise electro static dissipative), or a hydroscopic nylon blend. The device 10 is particularly advantageous in that the preferred ramp surface 40 in the handle 34 facilitates the insertion of seeds 26 of radioactive material and inert spacers 28 into the needle 12. The anti-static handle 34 eliminates, for practical purposes, the previously encountered risks of static interference, static cling of the spacers 28 and ignition spark generation. Finally, the localized friction portion 64 provides a controlled and predetermined amount of friction between the needle 12 and the stylet 14, preventing the stylet 14 from falling from the needle 12, while also preventing or reducing the risk of unintended ejection of the radioactive seeds 26 and spacers 28. Such friction is advantageously provided virtually the entire time any portion of the stylet 14 is received in the needle 12.

摘要翻译： 用于暴露于放射性的患者的近距离放射治疗装置10包括适于引入患者体内的细长构件，例如针或插管12，并且还包括可插入针12中的纵向通孔16中的探针14。设备10还包括 靠近针12的近端18或探针14的远端24的部分64，其提供针12和探针14之间的局部限定量的摩擦力。装置10还包括防静电手柄 34连接到针12.手柄34具有与针12的通孔16连通的内部斜面40，其具有截头圆锥形形状并且具有至少约16°的​​包含顶角。 局部摩擦部分64可以是探针14上的压接或凸缘48，或者针12中的针状物44或变形46。手柄34优选由聚碳酸酯，丙烯酸或缩醛树脂（这种树脂优选为 碳填充或静电耗散）或吸水尼龙混合物。 装置10的特别有利之处在于，手柄34中的优选斜面40便于将放射性材料和惰性间隔物28的种子26插入针12中。为了实际目的，防静电手柄34消除了先前遇到的 静电干扰的危险，间隔件28的静电附着和点燃火花的产生。 最后，局部摩擦部分64在针12和探针14之间提供可控和预定量的摩擦力，从而防止探针14从针12掉落，同时也防止或减少放射性种子26意外喷射的风险 这样的摩擦有利地实际上提供了探针14的任何部分被接收在针