公开(公告)号：US10589132B2

公开(公告)日：2020-03-17

申请号：US15772065

申请日：2016-10-27

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Eldad Tzahor ,  Elad Bassat

IPC: A61K38/17 ,  A61P9/10 ,  C12N5/077 ,  C07K14/47 ,  A61L27/54

Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.

公开(公告)号：US20200060994A1

公开(公告)日：2020-02-27

申请号：US16676495

申请日：2019-11-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael Fainzilber ,  Nicolas Panayotis

IPC: A61K31/135 ,  A61K31/575 ,  A61K31/395 ,  A61K31/397 ,  A61K31/44 ,  A61P25/22

Abstract: Agents and methods of treating a psychiatric stress disorder, Rett syndrome, MeCP2 duplication syndrome or multiple sclerosis are provided. Accordingly there is provided an agent capable of down-regulating activity and/or expression of importin alpha5 for use in the treatment of a medical condition selected from the group consisting of psychiatric stress disorder, Rett syndrome, MeCP2 duplication syndrome and multiple sclerosis. Also provided are methods of identifying an agent that inhibits activity of importin alpha5.

公开(公告)号：US20200046935A1

公开(公告)日：2020-02-13

申请号：US16545007

申请日：2019-08-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anat ARZI ,  Lee SELA ,  Anton PLOTKIN ,  Aharon WEISSBROD ,  Noam SOBEL

IPC: A61M21/02 ,  A61M16/10 ,  A61M15/08

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.

公开(公告)号：US10557853B2

公开(公告)日：2020-02-11

申请号：US15640545

申请日：2017-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/06 ,  G01N33/58 ,  C07D417/14 ,  C07K7/06 ,  C09K11/06 ,  G01N33/573 ,  G01N33/574

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20190382827A1

公开(公告)日：2019-12-19

申请号：US16525669

申请日：2019-07-30

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: C12Q1/689 ,  A61P1/00 ,  A61K31/132 ,  A61K31/417

Abstract: A method of determining the therapeutic effect of an agent, such as a metabolite, comprising: (a) exposing a pathological microbiome to the agent; and (b) comparing the signature of the pathological microbiome following the exposing with a reference signature of a healthy microbiome, wherein when the signature of the microbiome is statistically significantly similar to the healthy microbiome reference signature, it is indicative that the agent has a therapeutic effect on the microbiome. The agent may be provided to a subject having a pathological microbiome once it has been classified as therapeutic.

公开(公告)号：US20190354856A1

公开(公告)日：2019-11-21

申请号：US16412675

申请日：2019-05-15

Applicant: New York University ,  Yeda Research And Development Co. Ltd.

Inventor： Itay KEZURER ,  Yoram Eshel ,  Achiau Ludomirsky ,  Yaron Lipman

IPC: G06N3/08 ,  G06T3/60 ,  G06T3/20 ,  G06T7/00 ,  G06T11/00 ,  G16H30/40 ,  A61B8/00 ,  A61B5/00 ,  A61B8/13 ,  G09B23/28

Abstract: A downloadable navigator for a mobile ultrasound unit having an ultrasound probe, implemented on a portable computing device. The navigator includes a trained orientation neural network to receive a non-canonical image of a body part from the mobile ultrasound unit and to generate a transformation associated with the non-canonical image, the transformation transforming from a position and rotation associated with a canonical image to a position and rotation associated with the non-canonical image; and a result converter to convert the transformation into orientation instructions for a user of the probe and to provide and display the orientation instructions to the user to change the position and rotation of the probe.

公开(公告)号：US20190351004A1

公开(公告)日：2019-11-21

申请号：US16474831

申请日：2018-01-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Edna MOZES

IPC: A61K38/04 ,  A61P43/00

Abstract: The present invention provides compositions and methods for the treatment of Sjogren's syndrome (SS) and SS-related symptoms in human subjects by synthetic peptides based on the sequence of CDR1 of an anti-DNA monoclonal antibody.

公开(公告)号：US20190338247A1

公开(公告)日：2019-11-07

申请号：US16478477

申请日：2018-01-18

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG ,  Shlomit REICH-ZELIGER

IPC: C12N5/0783 ,  C07K14/725 ,  C12N5/00 ,  A61K35/17 ,  A61P35/04 ,  A61P35/00 ,  A61P35/02 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28

Abstract: An isolated cytotoxic T-lymphocyte (CTL), said CTL being a tolerance inducing cell and substantially depleted of alloreactivity, and wherein said CTL does not comprise a central memory T-lymphocyte (Tcm) phenotype, the CTL being transduced to express a cell surface receptor comprising a T cell receptor signaling module, is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20190327974A1

公开(公告)日：2019-10-31

申请号：US16476559

申请日：2018-01-09

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Colin JACKSON ,  Nir LONDON ,  Galen CORREY ,  Janelle SAN JUAN

IPC: A01N55/08 ,  A01N57/10

Abstract: This invention is directed to synergists for organophosphate (OP), carbamate (CM) and/or pyrethroid/synthetic pesticides (SP). This invention is further directed to a composition comprising organophosphate, carbamate, and/or pyrethroid/synthetic pyrethroid, and at least one boronic acid derivative. This invention further provides methods for killing insect pests.

公开(公告)号：US10457999B2

公开(公告)日：2019-10-29

申请号：US15318459

申请日：2015-06-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor Lubomirsky ,  Valery Kaplan

IPC: C22B3/00 ,  B01J19/08 ,  C01G55/00 ,  C22B11/06

Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material to a chlorinating treatment in the reaction zone at a predetermined temperature for a predetermined time period by putting the catalyst particulate material in contact with the chlorine containing gas. The method also includes applying an electromagnetic field to the chlorine-containing gas in the reaction zone to provide ionization of chlorine; thereby to cause a chemical reaction between platinum group metals and chlorine ions and provide a volatile platinum group metal-containing chloride product in the reaction zone. Following this, the volatile platinum group metal-containing chloride product is cooled to convert the product into solid phase platinum group metal-containing materials.