Topical gel formulation comprising organophosphate insecticide and preparation thereof
    8.
    发明授权
    Topical gel formulation comprising organophosphate insecticide and preparation thereof 有权
    包含有机磷酸酯杀虫剂的局部凝胶制剂及其制备

    公开(公告)号:US08012498B2

    公开(公告)日:2011-09-06

    申请号:US11179719

    申请日:2005-07-12

    摘要: The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

    摘要翻译: 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂,其包含:a)约0.1-10重量%的杀虫剂; b)至少约75重量%的选自低级烷基醇,酮,二醇及其混合物的有机溶剂,其中有机溶剂含有至少约40重量%的低级烷基 醇; 和c)至少一种选自纤维素聚合物,丙烯酸酯,甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的凝胶药物制剂优选含有马拉硫磷,并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。