公开(公告)号：US20210113610A1

公开(公告)日：2021-04-22

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K33/30 ,  A61K31/198 ,  A61K9/00 ,  A61K9/68 ,  A61P25/00 ,  G01N33/68 ,  A01K67/027 ,  A61K49/00 ,  A23L33/16 ,  A23L33/175 ,  A23K20/142 ,  A23K20/20

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US10918714B2

公开(公告)日：2021-02-16

申请号：US16175504

申请日：2018-10-30

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Wu

IPC: A61K39/39 ,  C07H15/18 ,  A61K39/00

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：US10882890B2

公开(公告)日：2021-01-05

申请号：US15328593

申请日：2015-07-24

Applicant: Academia Sinica

Inventor： Benjamin Pang-Hsien Tu ,  Rita Py Chen ,  Joseph Jen-Tse Huang ,  Yijuang Chern ,  Yu-Song Jang ,  Xiang-Me Lai ,  Tai-Yan Liao ,  Te-Hsien Kung

IPC: C07K14/47 ,  A61K38/00

Abstract: Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.

公开(公告)号：US20200299329A1

公开(公告)日：2020-09-24

申请号：US16823356

申请日：2020-03-19

Applicant: Academia Sinica

Inventor： Han-Chung WU ,  Yuan-Sung KUO

IPC: C07K7/06 ,  A61K47/64 ,  A61K38/43

Abstract: Disclosed herein is a biomolecule comprising a synthetic peptide for targeting thrombus, a pharmaceutical composition comprising the same, and uses thereof in the treatment of thromboembolism-related diseases. According to embodiments of the present disclosure, the synthetic peptide having the amino acid sequence of SEQ ID NO: 1, 2, or 3 exhibits a binding affinity and specificity to thrombus. Thus, the synthetic peptide may serve as a targeting element for delivering a therapeutic agent (e.g., an anticoagulant agent or a thrombolytic agent) to the thrombus thereby improving the therapeutic safety and efficacy of the therapeutic agent.

公开(公告)号：US20200299249A1

公开(公告)日：2020-09-24

申请号：US16362172

申请日：2019-03-22

Applicant: ACADEMIA SINICA

Inventor： Po-Wen CHUNG ,  Prasenjit BHAUMIK ,  Hao-Ju CHOU

IPC: C07D307/46 ,  B01J8/06 ,  B01D3/10

Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.

公开(公告)号：US10784343B2

公开(公告)日：2020-09-22

申请号：US15856325

申请日：2017-12-28

Applicant: ACADEMIA SINICA

Inventor： Chii Dong Chen ,  Li Chu Tsai ,  Chia Jung Chu ,  Ying Pin Wu

IPC: H01L29/06 ,  C12Q1/6825 ,  C12Q1/6874 ,  G01N27/414 ,  B82Y40/00 ,  H01L29/78 ,  G01N27/48

Abstract: The present invention discloses a Nanowire Field Effect Transistor Detection Device and the Detection Method thereof. The Nanowire Field Effect Transistor Detection Device of the present invention comprises: gate oxide, SiNW chip, surface oxide, and surface molecule layer. The circuit structure of the Nanowire Field Effect Transistor Detection Device comprises a first resistor, a second resistor, a first capacitor, a second capacitor, a third capacitor, a fourth capacitor, an AC voltage source, and an ammeter. In addition, the present invention provides a method for attaching the probe Ni-NTA to the Nanowire Field Effect Transistor Detection Device. Furthermore, the present invention provides a method for attaching the isooctyl trimethoxysilane molecule to the Nanowire Field Effect Transistor Detection Device.

公开(公告)号：US10683518B2

公开(公告)日：2020-06-16

申请号：US15723312

申请日：2017-10-03

Applicant: Academia Sinica

Inventor： Swee-Suak Ko ,  Min-Jeng Li

IPC: C12N15/82 ,  C07K14/415

Abstract: The present invention relates to a method for producing male sterile plant, a mutated nucleotide molecule comprising a nucleotide sequence of the transcription factor bHLH142 and an inserted T-DNA segment, and a novel transformed plant cell and a male-sterile mutant plant comprising the mutated nucleotide molecule, in which the transcription factor bHLH142 is not expressed. The present invention also relates to a novel reversible male sterile transgenic plant, wherein the transcription factor bHLH142 is overexpressed, and its preparation method. The bHLH gene is tissue specifically expresses in the anther and it plays a pivotal role in pollen development. Both the male sterile and reversible male sterile transgenic plants showed a completely male sterile phenotype, but the fertility of the reversible male sterile transgenic plant can be restored under low temperature.

公开(公告)号：US20190388535A1

公开(公告)日：2019-12-26

申请号：US16450810

申请日：2019-06-24

Applicant: Academia Sinica

Inventor： Yu-Chan CHAO ,  Wei-Ting HSU ,  Hui-Wen CHANG ,  Chia-Yu CHANG

IPC: A61K39/225 ,  C07K14/01 ,  C12N15/86 ,  G01N33/569

Abstract: A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.

公开(公告)号：US20190298664A1

公开(公告)日：2019-10-03

申请号：US16368654

申请日：2019-03-28

Applicant: Academia Sinica ,  Buddhist Tzu Chi Medical Foundation

Inventor： Tzu-Ching Meng ,  Chiu-Fen Yang ,  Michael Yu-Chih Chen

IPC: A61K31/10 ,  A61K33/242 ,  A61K31/727 ,  A61K45/06 ,  A61K9/00 ,  A61P9/10

Abstract: This disclosure provides method and kit for myocardial reperfusion and method for attenuating or reducing myocardial reperfusion injury. By administering protein tyrosine phosphatases inhibitor or a protein tyrosine kinases activator, cardiac injury caused by ischemia/reperfusion will be attenuated or reduced.

公开(公告)号：US20190282625A1

公开(公告)日：2019-09-19

申请号：US16333186

申请日：2017-09-13

Applicant: Che-Kun James SHEN ,  Yu-Chiau SHYU ,  Chun-Hao HUNG ,  Academia Sinica

Inventor： Che-Kun James SHEN ,  Yu-Chiau SHYU ,  Chun-Hao HUNG

IPC: A61K35/545 ,  C07K14/47 ,  A61P35/00 ,  C12N5/074 ,  C12N5/0735 ,  C12N5/0775

Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.