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    MEDICAGENIC ACID SAPONIN AND USES THEREOF
    52.
    发明申请
    MEDICAGENIC ACID SAPONIN AND USES THEREOF 审中-公开
    药用酸性痤疮及其用途

    公开(公告)号：US20090318377A1

    公开(公告)日：2009-12-24

    申请号：US12373476

    申请日：2007-07-13

    申请人： Louis-Philippe Vezina ,  Nathalie Landry ,  Joelle Pelletier ,  Sylvain Savard

    发明人： Louis-Philippe Vezina ,  Nathalie Landry ,  Joelle Pelletier ,  Sylvain Savard

    IPC分类号： A61K31/704 ,  A61P3/06

    CPC分类号： A61K31/575 ,  A23L33/105 ,  A61K31/704

    摘要： A cholesterol-lowering preparation comprising medicagenic acid saponin is disclosed. The amount of medicagenic acid saponin in the preparation is greater than 50% by weight to produce the cholesterol-lowering effect in an animal. A method of purifying a preparation of at least 30% medicagenic acid saponin is also disclosed. The preparation may be purified from alfalfa plants and used as a treatment for lowering cholesterol and triglycerides in an animal, in particular a human.

    摘要翻译： 公开了包含药用皂苷的降胆固醇制剂。 制剂中的药用植物皂苷的量大于50重量％，以在动物中产生降低胆固醇的作用。 还公开了一种纯化至少30％的药用植物皂苷的制剂的方法。 该制剂可以从苜蓿植物中纯化并用作降低动物，特别是人类中的胆固醇和甘油三酸酯的治疗剂。

    CPMV enhancer elements
    53.
    发明授权
    CPMV enhancer elements 有权

    公开(公告)号：US11884929B2

    公开(公告)日：2024-01-30

    申请号：US16880583

    申请日：2020-05-21

    申请人： Medicago Inc.

    发明人： Pierre-Olivier Lavoie ,  Marc-Andre D'Aoust

    IPC分类号： C12N15/82 ,  C12N7/04

    CPC分类号： C12N15/8216 ,  C12N7/045 ,  C12N15/8251

    摘要： An expression enhancer comprising a CPMV 5′UTR nucleotide sequence consisting of X nucleotides (CMPVX), where X=160, 155, 150, or 114 of SEQ ID NO:1, or consisting of a nucleotide sequence comprising from about 80% to 100% sequence similarity with CMPVX, where X=160, 155, 150, or 114 of SEQ ID NO:1 SEQ ID NO:1 is provided. The expression enhancer may further comprise a stuffer sequence fused to the 3′ end of the 5′UTR nucleotide sequence (CMPVX+, where X=160, 155, 150, or 114 of SEQ ID NO:1). The stuffer sequence may comprise one or more plant kozak sequences. Plants comprising the expression enhancer and methods using the expression enhancer are also described

    VIRUS LIKE PARTICLE PRODUCTION IN PLANTS
    57.
    发明申请
    VIRUS LIKE PARTICLE PRODUCTION IN PLANTS 有权

    公开(公告)号：US20210023205A1

    公开(公告)日：2021-01-28

    申请号：US17067049

    申请日：2020-10-09

    申请人： MEDICAGO INC.

    发明人： Marc-Andre D'Aoust ,  Manon Couture ,  Pierre-Olivier Lavoie ,  Louis-Philippe Vezina

    IPC分类号： A61K39/295 ,  C07K14/005 ,  C12N15/82 ,  C12N7/00

    摘要： A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain from a virus trimeric surface protein or fragment thereof, fused to an influenza transmembrane domain and cytoplasmic tail, into the plant, or portion of the plant, the ectodomain is from a non-influenza virus trimeric surface protein and heterologous with respect to the influenza transmembrane domain, and the cytoplasmic tail. The plant or portion of the plant are incubated under conditions that permit the expression of the nucleic acid, thereby producing the VLP. A VLP produced by this method are also provided.

    INFLUENZA VIRUS-LIKE PARTICLE PRODUCTION IN PLANTS
    59.
    发明申请
    INFLUENZA VIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开

    公开(公告)号：US20200255849A1

    公开(公告)日：2020-08-13

    申请号：US16516802

    申请日：2019-07-19

    申请人： MEDICAGO INC.

    发明人： Manon COUTURE ,  Marc-Andre D'AOUST ,  Louis-Philippe VEZINA

    IPC分类号： C12N15/82 ,  C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005

    摘要： A method of producing a virus like particle (VLP) in a plant comprising modified hemagglutinin is provided. The method comprises introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a modified influenza hemagglutinin (HA) protein into the plant, or portion of the plant, the modified HA protein comprises a modified proteolytic loop. Followed by incubating the plant or portion of the plant under conditions that permit the expression of the nucleic acids, thereby producing the VLP. The modified proteolytic loop may comprise one or more protease cleavage sites exhibiting reduced or abolished cleavage by a protease. The nucleotide sequence encoding the HA may be selected from the group consisting of B HA, C, H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16. Also described is a virus like particle (VLP) produced by the method, and plants expressing the VLP. The virus like particle (VLP) may comprise plant-specific N-glycans, or modified N-glycans.