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102 条记录 (耗时 0.019 秒)

    Compositions for electroporation
    51.
    发明授权
    Compositions for electroporation 失效
    电穿孔成分

    公开(公告)号：US07197359B1

    公开(公告)日：2007-03-27

    申请号：US10110712

    申请日：2000-04-06

    申请人： Yoshihiro Tokudome ,  Koji Owaku ,  Kenichi Goto ,  Kenji Sugibayashi

    发明人： Yoshihiro Tokudome ,  Koji Owaku ,  Kenichi Goto ,  Kenji Sugibayashi

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30 ,  A61K9/0009

    摘要： The present invention relates to compositions for electroporation which are useful in elevating percutaneous absorbability of drugs, etc. By controlling electrolyte concentration of compositions for electroporation so as to make an osmotic pressure of the compositions not more than a physical osmotic pressure, the percutaneous absorbability of drugs can be elevated.

    摘要翻译： 本发明涉及电穿孔用组合物，其可用于提高药物的经皮吸收性等。通过控制用于电穿孔的组合物的电解质浓度，使得组合物的渗透压不超过物理渗透压，经皮吸收能力 药物可以升高。

    Double-coat type make-up cosmetic product containing aluminum powder
    54.
    发明授权
    Double-coat type make-up cosmetic product containing aluminum powder 失效
    双层包装铝粉包含铝粉的化妆品

    公开(公告)号：US5238678A

    公开(公告)日：1993-08-24

    申请号：US843445

    申请日：1992-02-28

    申请人： Junji Shiozawa ,  Kazuhiro Nishikata ,  Naoki Nakamura

    发明人： Junji Shiozawa ,  Kazuhiro Nishikata ,  Naoki Nakamura

    IPC分类号： A61K8/26 ,  A61K8/81 ,  A61Q1/02 ,  A61Q1/12

    CPC分类号： A61K8/26 ,  A61K8/8152 ,  A61Q1/02 ,  A61Q1/12 ,  Y10S514/844

    摘要： Disclosed are a make-up cosmetic product containing, as a film-forming agent, a copolymer with a mean molecular weight of from 10,000 to 1,000,000, as prepared by copolymerizing an acrylate and a polymerizing carboxylic acid at a determined ratio or by copolymerizing an acrylate, at least one selected from vinyl acetate, methyl methacrylate and acrylamide and a polymerizing carboxylic acid at a determined ratio; and a double-coat type make-up cosmetic product comprising, a combination of an under make-up base for a first layer containing as a main component an adhesive film-forming agent such as said copolymer and a finishing make-up material for a second layer containing as a main component an aluminum powder.

    摘要翻译： 公开了一种化妆品，其含有作为成膜剂的平均分子量为10,000〜1,000,000的共聚物，其通过以规定的比率共聚丙烯酸酯和聚合羧酸而制备，或通过共聚丙烯酸酯 选自乙酸乙烯酯，甲基丙烯酸甲酯和丙烯酰胺中的至少一种和以确定的比例聚合的羧酸; 以及双层型化妆品，其特征在于，包含以下成分的组合：作为主要成分的含有所述共聚物的粘合剂成膜剂的第一层的补充底物和用于 以铝粉为主要成分的第二层。

    Cosmetics
    58.
    发明授权
    Cosmetics 失效
    化妆品

    公开(公告)号：US4250193A

    公开(公告)日：1981-02-10

    申请号：US922112

    申请日：1978-07-05

    申请人： Michio Ochiai ,  Noriaki Tonooka ,  Kenkichi Matubara

    发明人： Michio Ochiai ,  Noriaki Tonooka ,  Kenkichi Matubara

    IPC分类号： C07C43/13 ,  A61K8/30 ,  A61K8/39 ,  A61Q5/00 ,  A61Q19/00 ,  C07C41/00 ,  C07C41/02 ,  C07C43/10 ,  C07C67/00 ,  A61K7/48

    CPC分类号： A61K8/39 ,  A61Q19/00 ,  A61Q5/00 ,  A61Q1/14 ,  A61Q19/002 ,  A61Q19/10

    摘要： Disclosed are cosmetics containing an oily bisdiglyceryl ether compound. This novel compound can be prepared by adding an alkylene glycol, dialkylene glycol, trialkylene glycol or tetraalkylene glycol dropwise to an alkylglycidyl ether using as a catalyst a boron trifluoride ether complex, other Lewis acid, sodium hydroxide or potassium hydroxide and removing the catalyst with the use of sodium carbonate, calcium carbonate, potassium carbonate, these aqueous solutions or water upon heating, followed by rectification of the resultant oily liquid under reduced pressures. The cosmetics of this type do not cause any dermatitis or skin disease due to the absence of surface active agents.

    摘要翻译： 公开了含有油性双二甘油醚化合物的化妆品。 该新型化合物可以通过使用三氟化硼醚络合物，其他路易斯酸，氢氧化钠或氢氧化钾作为催化剂将烷撑二醇，二亚烷基二醇，三亚烷基二醇或四亚烷基二醇滴加到烷基缩水甘油醚中并除去催化剂 在加热下使用碳酸钠，碳酸钙，碳酸钾，这些水溶液或水，然后在减压下精制所得油状液体。 这种化妆品不会由于没有表面活性剂而引起任何皮炎或皮肤疾病。

    SKIN LIGHTENING AGENT
    59.
    发明申请
    SKIN LIGHTENING AGENT 有权

    公开(公告)号：US20210196599A1

    公开(公告)日：2021-07-01

    申请号：US17057320

    申请日：2019-04-24

    申请人： POLA CHEMICAL INDUSTRIES, INC.

    发明人： Shoko SASSA ,  Yasuhito MORI ,  Yuko SAITOH

    IPC分类号： A61K8/44 ,  A61Q19/02

    摘要： The object is to provide a skin whitening agent having an excellent skin whitening effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of the skin whitening agent: wherein, X represents an alkylene group having 1 to 2 carbon atoms, where a hydrogen atom may be substituted with a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom, or an optionally branched alkyl group having 1 to 6 carbon atoms; and R2 represents a hydrogen atom or an optionally branched acyl group having 1 to 6 carbon atoms.

    Melanin production inhibitor
    60.
    发明授权
    Melanin production inhibitor 有权
    黑色素生成抑制剂

    公开(公告)号：US08846012B2

    公开(公告)日：2014-09-30

    申请号：US13131827

    申请日：2009-12-22

    申请人： Kouji Yokoyama ,  Makoto Kimura ,  Masashi Tamai ,  Yuko Saitoh ,  Tomomi Kato ,  Yu Ikeda

    发明人： Kouji Yokoyama ,  Makoto Kimura ,  Masashi Tamai ,  Yuko Saitoh ,  Tomomi Kato ,  Yu Ikeda

    IPC分类号： A61K8/49 ,  C07D233/58 ,  C07D401/06 ,  A61K8/44 ,  A61K8/41 ,  A61K8/34 ,  C07D207/404 ,  A61Q19/02 ,  C07D213/38 ,  C07D213/30 ,  C07D295/03 ,  C07D207/12 ,  C07D295/096

    CPC分类号： A61K8/4946 ,  A61K8/31 ,  A61K8/34 ,  A61K8/41 ,  A61K8/411 ,  A61K8/418 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/494 ,  A61K2800/74 ,  A61Q19/02 ,  C07D207/12 ,  C07D207/404 ,  C07D213/30 ,  C07D213/38 ,  C07D233/58 ,  C07D295/03 ,  C07D295/096 ,  C07D401/06

    摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.

    摘要翻译： 公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。 黑色素产生抑制剂由通式（1）表示（不包括克霉唑）和/或其药理学上可接受的盐。 在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基。 A1，A2和A3中的至少一个选自芳基和芳族杂环基，A1，A2和A3中所含的碳原子总数为6〜50，A1，A2和A3中的至少2个 表示芳基或芳族杂环基，相邻的两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基。 当R1和R2中的一个是氧代基时，另一个不存在。 R3选自氢原子和碳原子数为1〜8的烃基，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代。 化合物中存在的R3的数目对应于X，并且当存在两个或更多个R 3时，R 3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且末端 的R3可以结合到与A1，A2和A3结合的碳原子上，从而形成环。