公开(公告)号：US20060122503A1

公开(公告)日：2006-06-08

申请号：US11342011

申请日：2006-01-27

申请人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Nancy Forcier

发明人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Nancy Forcier

IPC分类号： A61B6/00

CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by an delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

公开(公告)号：US20060036165A1

公开(公告)日：2006-02-16

申请号：US11238201

申请日：2005-09-29

申请人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick ,  Frank Louw ,  Stephen De Santis

发明人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick ,  Frank Louw ,  Stephen De Santis

IPC分类号： A61B6/00

CPC分类号： A61M37/0069 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/08021 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/222

摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

公开(公告)号：US20050245842A1

公开(公告)日：2005-11-03

申请号：US11179277

申请日：2005-07-11

申请人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick

发明人： Fred Burbank ,  Paul Lubock ,  Michael Jones ,  Richard Quick

IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61F2/82

CPC分类号： A61B10/04 ,  A61B10/02 ,  A61B10/0241 ,  A61B10/0266 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/12 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2019/5487 ,  A61B2019/5491 ,  A61B2090/3908 ,  A61B2090/3991

摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

摘要翻译： 提供了设备和方法，用于使用固定剂将医疗器械牢固地固定在患者体内的期望的组织上。 这样的医疗器械可以包括定位线或组织采集器械，例如活检器械。 在组织采集仪器的情况下，本发明人已经发现了将组织采集仪器的远端牢固地固定到特定组织靶区域的显着优点。 例如，这种方法允许成像环境与程序环境分离，从而不需要使用诸如立体定向成像设备之类的昂贵和经常不可用的成像设备。 在优选的实施方案中，使用粘合剂，例如粘合剂，手术胶或溶剂作为固定剂。

公开(公告)号：US06875182B2

公开(公告)日：2005-04-05

申请号：US10136700

申请日：2002-04-30

申请人： John L. Wardle ,  Fred H. Burbank ,  Paul Lubock

发明人： John L. Wardle ,  Fred H. Burbank ,  Paul Lubock

IPC分类号： A61B20060101 ,  A61B10/00 ,  A61B10/02 ,  A61B10/04 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/14 ,  A61B19/00

CPC分类号： A61B10/0233 ,  A61B10/02 ,  A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/37 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00291 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1412 ,  A61B2018/1425 ,  A61B2018/1455 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： Devices, methods and systems for obtaining biopsy tissue samples are provided. Flexible hollow tubes with a rail and a tip cutting element advance within a shaft with an aperture and a bore having a ramp, so that the cutting element emerges from the aperture and cuts tissue as it moves over the ramp. Either or both shaft and bore may have guides, which may engage each other to guide the tube along a tissue cutting pathway. A tube may have a rail and the bore a channel which engages the rail and guides the tube. Cut tissue may be acquired and transported proximally within the tube by suction to a tissue collection chamber. Multiple tissue samples may be obtained from a single insertion point by rotation and/or translation of the shaft between biopsies.

摘要翻译： 提供了用于获得活检组织样本的装置，方法和系统。 具有导轨和尖端切割元件的柔性中空管在具有孔的轴内延伸并且具有斜坡的孔，使得切割元件从孔中露出并且在组织移动通过斜坡时切割组织。 轴和孔中的一个或两个可以具有引导件，其可以彼此接合以沿着组织切割路径引导管。 管可以具有轨道并且孔具有与轨道接合并引导管的通道。 可以通过抽吸将组织收集并在管内向近端运送到组织收集室。 可以通过在活组织检查之间的轴的旋转和/或平移从单个插入点获得多个组织样本。

公开(公告)号：US20050004492A1

公开(公告)日：2005-01-06

申请号：US10903786

申请日：2004-07-29

申请人： Fred Burbank ,  Michael Jones ,  Paul Lubock

发明人： Fred Burbank ,  Michael Jones ,  Paul Lubock

IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.

公开(公告)号：US20040236212A1

公开(公告)日：2004-11-25

申请号：US10444770

申请日：2003-05-23

申请人： SenoRx, Inc.

发明人： Michael L. Jones ,  Paul Lubock ,  Lloyd H. Malchow

IPC分类号： A61B006/00

CPC分类号： A61B90/39 ,  A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00898 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3987

摘要： The invention is directed to an intracorporeal marker, a delivery device and assembly for such marker and the method of delivering one or more of the markers to an intracorporeal location within a patient. The marker is a body formed at least in part of a bioabsorbable fibrous material such as a fibrous mat or fabric. The delivery devices preferably also include one or more bioabsorbable short term markers which are configured to expand within the body cavity due to contacting a body fluid. The fibrous marker has a radiographically detectable member which preferably hold a portion of the fibrous body in a compressed condition. Preferably, the fibrous marker has a fibrous felt core formed of bioabsorbable material with a fabric jacket formed of bioabsorbable material. Therapeutic, diagnostic and binding agents may be incorporated into the fibrous body of the marker.

摘要翻译： 本发明涉及一种体内标记物，用于这种标记的递送装置和装置，以及将一种或多种标记递送到患者体内位置的方法。 标记物是形成至少部分生物可吸收纤维材料如纤维垫或织物的主体。 递送装置优选还包括一个或多个生物可吸收的短期标记物，其构造成由于接触体液而在体腔内膨胀。 纤维标记具有可放射线检测的构件，其优选地将纤维体的一部分保持在压缩状态。 优选地，纤维标记物具有由生物可吸收材料形成的纤维毡芯，其具有由生物可吸收材料形成的织物护套。 可以将治疗性，诊断性和结合剂掺入标记物的纤维体内。

公开(公告)号：US20040167428A1

公开(公告)日：2004-08-26

申请号：US10642406

申请日：2003-08-15

申请人： SenoRx, Inc.

发明人： Richard L. Quick ,  Frank R. Louw ,  Paul Lubock ,  Martin V. Shabaz

IPC分类号： A61B010/00

CPC分类号： A61B10/0233 ,  A61B10/02 ,  A61B10/0266 ,  A61B10/0275 ,  A61B10/0283 ,  A61B17/32002 ,  A61B17/3417 ,  A61B90/30 ,  A61B90/39 ,  A61B2010/0208 ,  A61B2010/0225 ,  A61B2017/0046 ,  A61B2017/00473 ,  A61B2017/3405 ,  A61B2017/3454 ,  A61B2090/0811 ,  A61B2090/309 ,  B23Q17/2404 ,  F21V33/0068

摘要： The invention is directed to devices and methods for separating and collecting a tissue specimen from a patient's target site. The device includes a probe member with a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having an tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member. The tissue cutting edge of the tissue cutting member preferably is longitudinally oriented and may have a cutting angle less than 90null with respect to the longitudinal axis of the tissue cutting member.

摘要翻译： 本发明涉及用于从患者的目标部位分离和收集组织标本的装置和方法。 该装置包括具有穿透性远侧末端和组织接收孔的探针构件，以及组织切割构件，该组织切割构件可旋转地设置在探针构件内，以通过孔切割被拉入装置内部的组织样本。 孔的纵向边缘优选地被锐化以接合组织切割构件的切割边缘。 可以在切割构件的内腔中设置真空以将组织输送通过其中。 组织切割构件的旋转，旋转振动和/或纵向往复运动有效地将组织标本与周围组织分开。 具有组织接收孔的进入套管可以同心地设置在探针构件内并且围绕组织切割构件。 组织切割构件的组织切割边缘优选地纵向定向并且可以具有相对于组织切割构件的纵向轴线小于90°的切割角度。

公开(公告)号：US20030023239A1

公开(公告)日：2003-01-30

申请号：US10179933

申请日：2002-06-21

申请人： SenoRx, Inc.

发明人： Fred H. Burbank ,  Paul Lubock ,  Martin Shabaz ,  Frank Louw

IPC分类号： A61B018/14 ,  A61B017/32

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B10/0275 ,  A61B10/0283 ,  A61B10/04 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/37 ,  A61B2010/0208 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00291 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1412 ,  A61B2018/1425 ,  A61B2018/1455 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.

摘要翻译： 一种使用该装置来访问患者体内期望的组织部位并将组织标本与适于评估的组织部位分离的装置和方法。 该装置包括探针构件，该探针构件具有固定到探针的远端并远离间隔开的弓形组织切割RF供电的电极，以及小尺寸的远端，当其内腔经受真空时，用于样本的固定的组织 到远端的表面。 优选地固定到支撑管的远端的圆形组织切割刀片构造成沿着探针构件的轴线旋转并纵向移动，其有效地从固定到探针构件的远端的表面的组织切断组织样本 。 支撑管覆盖分离的样本，并且可以设置在进入的插管内。

公开(公告)号：US20020161298A1

公开(公告)日：2002-10-31

申请号：US10087114

申请日：2002-02-27

申请人： SenoRx, Inc.

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

IPC分类号： A61B019/00

CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

摘要： Detectable markers that may be introduced into a cavity created by removal of a biopsy specimen to mark the location of the biopsy site so that it may be located in a subsequent medical/surgical procedure. The markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

摘要翻译： 可以被引入通过去除活组织检查样本以标记活检部位的位置而产生的空腔的可检测标记，使得其可以位于随后的医疗/外科手术中。 标记物以足够的量保持存在，以允许在引入后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除或以其他方式不干扰第二次活检部位附近的组织的成像 时间点（如5-7个月）。

公开(公告)号：US10786604B2

公开(公告)日：2020-09-29

申请号：US14272075

申请日：2014-05-07

申请人： SenoRx, Inc.

发明人： Amit Govil ,  Michael L. Jones ,  Paul Lubock

IPC分类号： A61L31/14 ,  A61F2/00 ,  A61F2/02 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/18

摘要： In one form, the invention is directed to a method for forming a porous implant suitable for a cavity from which tissue has been removed, including mixing soluble alginate and a radiopaque imaging agent with water; incorporating a gas or a pore forming agent into the alginate-water mixture; transferring the alginate-water mixture with the gas or the pore forming agent into a mold to form the mixture into a solid body of desired shape; removing the water from the body; and converting at least part of the soluble alginate to a less soluble alginate. In another form, the invention includes forming a mixture by mixing about 0.5 percent to about 4 percent by weight chitosan into an acidified aqueous solution containing 1 percent to 25 percent by weight acetic acid, along with about 0.5 percent to about 5 percent by weight of a powdered radiopaque imaging agent.