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85 条记录 (耗时 0.033 秒)

    POLYPEPTIDE CONJUGATES
    51.
    发明申请
    POLYPEPTIDE CONJUGATES 有权

    公开(公告)号：US20220008551A1

    公开(公告)日：2022-01-13

    申请号：US17293134

    申请日：2019-11-18

    申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)

    发明人： Dhr. Ferenc Alexander SCHEEREN ,  Dhr. Huib OVAA ,  Mw. Angela Fouad EL HEBIESHY

    IPC分类号： A61K47/68 ,  A61K47/64

    摘要： Disclosed herein is are conjugates that comprise a ubiquitin dimer or multimer, comprising a distal moiety conjugated to a proximal moiety. The distal moiety comprises a polypeptide comprising a distal ubiquitin at its C-terminus, said ubiquitin comprising at least one of the following mutations: K6X, K11X, K27X, K29X, K33X, K48X, K48X, K63X, or K63X, where X is selected from R, A or C. The proximal moiety comprises a polypeptide comprising either a proximal ubiquitin at its C-terminus or a proximal ubiquitin at its N-terminus; said ubiquitin comprising a blocked C-terminus. The distal moiety is conjugated to the proximal moiety via an amide bond from G76 of the distal ubiquitin to one of M1, K6, K11, K27, K29, K33, K48, or K63 of the proximal ubiquitin. Also provided are methods for the production of said conjugates, formulations comprising said conjugates and methods of using said conjugates.

    FLUID VESSEL INSERTION DEVICE WITH AUTOMATIC NEEDLE RETRACTION
    54.
    发明申请
    FLUID VESSEL INSERTION DEVICE WITH AUTOMATIC NEEDLE RETRACTION 有权

    公开(公告)号：US20210338987A1

    公开(公告)日：2021-11-04

    申请号：US17281339

    申请日：2019-10-04

    申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)

    发明人： Wouter Jan GEELHOED ,  Joris Ivo ROTMANS

    IPC分类号： A61M25/06 ,  A61M5/158

    摘要： The present invention relates to a fluid vessel insertion device comprising a) a puncture member arranged for location within a cannulation sheet and comprising an interior lumen; b) a retractor arranged to actuate the puncture member relative to the cannulation sheet in use between i) a first situation in which a distal end of the puncture member protrudes beyond an end of the cannulation sheet, and ii) a second situation in which the distal end of the puncture member is within the cannulation sheet; c) a chamber in fluid communication with an exterior of the device only via the lumen and distal end of the puncture member; and d) a sheet of material located in the chamber to prevent the proximal end of the puncture member from moving; wherein the distal end of the puncture member is configured as a puncturing end having a distal n end opening for insertion into a fluid vessel when in use, and wherein the retractor triggers retraction of the puncture member between the first and the second situation automatically in response to wetting of the sheet of material by a fluid entering the puncture member lumen, whereby the sheet of material is comprising a material whose tensile strength is reduced upon contact with the fluid, and breaks under the pressure of the retractor.