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公开(公告)号：US12164181B2
公开(公告)日：2024-12-10
申请号：US18213147
申请日：2023-06-22
Inventor： James T. Schwiegerling
Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the performance of the multifocal lens.
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公开(公告)号：US20240402301A1
公开(公告)日：2024-12-05
申请号：US18693196
申请日：2022-09-22
Inventor： Wenhua He , Salkat Guha
IPC: G01S7/48 , G01S7/481 , H04B10/112 , H04B10/70
Abstract: An optical beam is provided from a transmitter aperture to a receiver aperture that receives the optical beam after displacement by a path shifting component. Received initial displacement information characterizing at least one of: an initial estimate of the displacement, or an indication that the displacement is below a predetermined threshold. Received input beams each have a different spatial mode, from a set of mutually orthogonal spatial modes that include: a lowest order spatial mode, a highest order spatial mode, and one or more intermediate order spatial modes. A relative amount of each of the input beams to be included in the optical beam is determined based at least in part on: corresponding diffraction loss estimates for each of the input beams, and the initial displacement information. One of the input beams that has a largest relative amount in the optical beam is one of the intermediate order spatial modes.
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公开(公告)号：US20240395170A1
公开(公告)日：2024-11-28
申请号：US18674202
申请日：2024-05-24
Inventor： Diego Celdran-Bonafonte
IPC: G09B23/34
Abstract: Surgical training devices, kits, and associated methods are disclosed. The surgical training devices include a body shaped to correspond to an animal. The surgical training devices also include an insert for removable insertion into an opening in the body. The insert can be to be covered by a cover, which can be removably attached to the insert. An entirety or majority of the body, the insert, and the cover can be formed of materials sourced from sources other than the animal.
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公开(公告)号：US20240390455A1
公开(公告)日：2024-11-28
申请号：US18797990
申请日：2024-08-08
Inventor： Olga Rafikova , Ruslan Rafikov
Abstract: Inositol monophosphatase 1 (IMPA1) controls the activity of the primary cell proliferation signaling cascades activated through the inositol-dependent phosphorylation of Akt and PKCs. Furthermore, IMPA1-mediated control of cell proliferation involves the recruitment of cytosolic IMPA1 on a plasma membrane by the receptor for advanced glycation endproducts (RAGE). Interaction between IMPA1 and RAGE redistributes inositols from the cytosolic pool to membrane microdomains and amplifies the synthesis of membrane-bound phosphatidylinositols (PtdIns) to trigger inositol-dependent cell proliferation. Thus, the peptide compositions described herein inhibit the formation of the complex between IMPA1 and RAGE (e.g., a pathogenic complex) to control over-proliferative cells.
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55.发明申请公开(公告)号：US20240386710A1
公开(公告)日：2024-11-21
申请号：US18788731
申请日：2024-07-30
Applicant: Mayo Foundation for Medical Education and Research , Arizona Board of Regents on Behalf of Arizona State University
Inventor： Leland S. Hu , Kristin R. Swanson , J. Ross Mitchell , Nhan L. Tran , Jing Li , Teresa Wu
IPC: G06V10/776 , G06T7/00 , G06T7/11
Abstract: Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.
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Patent Agency Ranking
公开(公告)号：US20240384216A1
公开(公告)日：2024-11-21
申请号：US18622737
申请日：2024-03-29
Inventor： Bruce RITTMANN , Everett EUSTANCE , Yen-Jung LAI , Justin FLORY , Diana CALVO MARTINEZ , Tarun SHESH
Abstract: Disclosed herein are methods and systems for membrane carbonation for cultivating microalgas and other microorganisms that utilize a gaseous substrate, as well as to upgrade the quality of mixed-gas streams.
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公开(公告)号：US20240369906A1
公开(公告)日：2024-11-07
申请号：US18778281
申请日：2024-07-19
Inventor： Linran FAN , Pao-Kang CHEN
Abstract: The adaptive methodology of (purposefully, intentionally aperiodically) poling of an optical waveguide made in a nonlinear material substrate to achieve a continuous increase of overall nonlinear conversion efficiency with increase in the length of such waveguide. As a result of such poling, the variation of at least a waveguide thickness is compensated by adjusting the poling period along the waveguide to match the local momentum difference of the nonlinear process. For a second-harmonic generation, a near-ideal performance of the nonlinear energy conversion process was demonstrated even for a 21 mm long waveguide (with the SHG efficiency as high as 9415%/W and a 82.6% absolute power conversion efficiency). The adaptive poling methodology can also be applied to compensate other systematic inhomogeneity of a WG device in, for example, etching depth, diffusion depth, dose of lithographic exposure of the nonlinear material, and doping density across the nonlinear material substrate.
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公开(公告)号：US20240369825A1
公开(公告)日：2024-11-07
申请号：US18686653
申请日：2022-08-25
Inventor： Yuzuru Takashima
Abstract: An optical system for modulating a light beam emitted by a laser light source. The system includes a phase light modulation device positioned to receive the laser light beam, a 4f relay optics positioned to receive light emitted from the phase light modulation device, and having a tilt mirror positioned in the light path, the tilt mirror having a center hole that permits light to pass therethrough and relay to a focusing lens, whereby a modulated and linearly polarized beam is transmitted; a quarter wave plate having a polarized beam splitter positioned to receive the modulated and linearly polarized beam; and a digital micromirror device that includes an array of micromirrors and that modulates amplitude of light in a pixelated manner by redirecting light into two directions, on- and off-directions, by electrically controlling the tilt angle of each micromirror.
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公开(公告)号：US20240369738A1
公开(公告)日：2024-11-07
申请号：US18654918
申请日：2024-05-03
Inventor： Chao WANG , Yu YAO , Shinhyuk CHOI , Jiawei ZUO
IPC: G02B1/00 , G01J4/02 , G03F7/00 , G03F9/00 , H01L27/146
Abstract: A polarimetric metastructure is disclosed that includes a metasurface structure, one or more vertically coupled double-layer metallic gratings, and a dielectric spacer layer between the metasurface structure and the vertically coupled double-layer metallic gratings.
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公开(公告)号：US20240352553A1
公开(公告)日：2024-10-24
申请号：US18569142
申请日：2022-06-09
Inventor： Jaeheon Lee , Jiajia Wu
CPC classification number: C22B7/006 , C22B3/04 , C22B3/44 , C22B23/0407 , C22B23/0461 , C22B26/12 , C22B47/00 , H01M10/54
Abstract: Methods are disclosed for leaching metal-containing materials, such as those contained in the cathode of spent lithium-ion batteries, using a leach solution of an amino acid and a reducing agent. The metal-containing material is treated with the leach solution to recover at least one metal. For example, when the metal-containing material is lithium cobalt (III) oxide (LiCoO2), leaching with the leach solution of the present invention enables the recovery of the lithium and/or cobalt metal.
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