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公开(公告)号：US20240369738A1
公开(公告)日：2024-11-07
申请号：US18654918
申请日：2024-05-03
Inventor： Chao WANG , Yu YAO , Shinhyuk CHOI , Jiawei ZUO
IPC: G02B1/00 , G01J4/02 , G03F7/00 , G03F9/00 , H01L27/146
Abstract: A polarimetric metastructure is disclosed that includes a metasurface structure, one or more vertically coupled double-layer metallic gratings, and a dielectric spacer layer between the metasurface structure and the vertically coupled double-layer metallic gratings.
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公开(公告)号：US20230091639A1
公开(公告)日：2023-03-23
申请号：US17908795
申请日：2021-03-03
Inventor： Chao WANG , Pengkun XIA
IPC: C23C16/04 , G01N33/487 , G01N27/04 , C12Q1/6869 , B01L3/00 , C23C16/34 , C23C16/02
Abstract: Fabricating a nanopore sensor includes depositing a first and second oxide layers on first and second sides of a sapphire substrate. The second oxide layer is patterned to form an etch mask having a mask opening in the second oxide layer. A crystalline orientation dependent wet anisotropic etch is performed on the second side of the sapphire substrate using the etch mask to form a cavity having sloped side walls through the sapphire substrate to yield an exposed portion of the first oxide layer, each of the sloped side walls being a crystalline facet aligned with a respective crystalline plane of the sapphire substrate. A silicon nitride layer is deposited on the first oxide layer. The exposed portion of the first oxide layer in the cavity is removed, thereby defining a silicon nitride membrane in the cavity. An opening is formed through the silicon nitride membrane.
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Patent Agency Ranking
公开(公告)号：US20220163522A1
公开(公告)日：2022-05-26
申请号：US17532969
申请日：2021-11-22
Inventor： Chao WANG , MD Ashif IKBAL
IPC: G01N33/553 , G01N33/52 , G01N33/543
Abstract: The present disclosure provides compositions and methods related to COVID-19 detection. In particular, the present disclosure provides plasmonic metal nanoparticles (MNPs) for use in assays to detect and/or quantify neutralizing antibodies to SARS-CoV-2 in a sample. The compositions and methods of the present disclosure provide a portable, inexpensive, rapid, and accurate antibody assay platform that can be used to evaluate protective immune responses in individuals who have recovered from COVID-19 infection, as well as the efficacy, strength, and duration of vaccines that are under development or in clinical trials.
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公开(公告)号：US20220275972A1
公开(公告)日：2022-09-01
申请号：US17628627
申请日：2020-07-08
Abstract: Reflectors for concentrated solar power as well as systems and methods for additively manufacturing the reflectors is provided. The disclosed method can directly print metal films from an aqueous precursor solution onto a substrate with little to no post-fabrication treatment to achieve highly reflective surfaces with low surface roughness. The method provides precise control to form a metal film having an RMS surface roughness of about 2 to about 5 nm and a relative reflectivity of about 90% to about 96% at 550 nm on a substrate having an area of at least 1 square meter.
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公开(公告)号：US20240377418A1
公开(公告)日：2024-11-14
申请号：US18659490
申请日：2024-05-09
Inventor： Chao WANG , MD Ashif IKBAL
IPC: G01N33/94 , B01L3/00 , G01N33/543
Abstract: Provided herein are methods of detecting cannabinoid molecules in a sample. The methods include contacting the sample with a plurality of plasmonic metal nanoparticles (MNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first and second epitopes of the cannabinoid molecule under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first and second epitopes of the cannabinoid molecule in the sample to produce bound cannabinoid molecules. The methods also include detecting the cannabinoid molecules when aggregations of MNPs coated with the target cannabinoid molecules form by connecting with one another. Related compositions, reaction mixtures, devices, kits, and systems are also provided.
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公开(公告)号：US20220099675A1
公开(公告)日：2022-03-31
申请号：US17489273
申请日：2021-09-29
Inventor： Xiahui CHEN , Shoukai KANG , Md Ashif IKBAL , Zhi ZHAO , Liangcai GU , Chao WANG
IPC: G01N33/569 , G01N33/543 , G01N21/78
Abstract: Provided herein are methods of detecting Ebola virus in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first or second epitopes of glycoproteins, such as secreted glycoproteins (sGPs) from the Ebola virus under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first or second epitopes of the glycoproteins from the Ebola virus in the sample to produce bound glycoproteins. The methods also include detecting the glycoproteins from the Ebola virus when aggregations of the bound glycoproteins form with one another. Related reaction mixtures, devices, kits, and systems are also provided.
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公开(公告)号：US20230375547A1
公开(公告)日：2023-11-23
申请号：US18247161
申请日：2021-09-29
Inventor： Xiahui CHEN , Shoukai KANG , MD Ashif IKBAL , Zhi ZHAO , Liangcai GU , Chao WANG
IPC: G01N33/569 , G01N33/543
CPC classification number: G01N33/56983 , G01N33/54346 , G01N33/54386 , G01N2333/08 , G01N2469/10
Abstract: Provided herein are methods of detecting Ebola virus in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) that are conjugated with antibodies, or antigen binding portions thereof, that bind to an epitope of a secreted glycoprotein (sGP) from the Ebola virus under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the epitope of the sGP from the Ebola virus in the sample to produce bound sGP. The methods also include detecting the sGP from the Ebola virus when aggregations of the bound sGP form with one another. Related reaction mixtures, devices, kits, and systems are also provided.
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