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公开(公告)号:US11680074B2
公开(公告)日:2023-06-20
申请号:US17570040
申请日:2022-01-06
申请人: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Ludwik Leibler , Renaud Nicolay
CPC分类号: C07F5/025 , C07F7/1872 , C08G79/08
摘要: The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R′3 or R4 is a radical of formula —X; or one of R1, R2, R3, R′3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
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公开(公告)号:US20230183383A1
公开(公告)日:2023-06-15
申请号:US17926341
申请日:2021-05-19
IPC分类号: C08B11/155 , C08B11/15 , C08B11/14
CPC分类号: C08B11/155 , C08B11/15 , C08B11/14
摘要: A method for chemically functionalizing a cellulosic material using a diazo compound, and the functionalized cellulosic materials obtained by the method. The cellulosic materials may be functionalized with a functional groups selected from hydrophobic agents, catalyzing agents, sensing agent, diagnostic agents, printing agents chelating agents, ligands, antioxidants, antimicrobial agents, or drugs. Also, the uses of functionalized cellulosic materials obtained by the method in a variety of applications.
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公开(公告)号:US20230181539A1
公开(公告)日:2023-06-15
申请号:US17999340
申请日:2021-05-19
申请人: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ D'AIX MARSEILLE , ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE , ECOLE NORMALE SUPÉRIEURE DE LYON , INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT , UNIVERSITÉ CLAUDE BERNARD - LYON 1
发明人: Pierre-Olivier VIDALAIN , Antoine NOUGAIREDE , Franck TOURET , Patrice ANDRE , Vincent LOTTEAU , Xavier Nicolas LAMBALLERIE , Yves Louis JANIN
IPC分类号: A61K31/4196 , A61K38/21 , A61K31/675 , A61K31/513 , A61K31/427 , A61K31/4706
CPC分类号: A61K31/4196 , A61K38/21 , A61K31/675 , A61K31/513 , A61K31/427 , A61K31/4706
摘要: Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new beta-coronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that BAY-2402234 is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
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公开(公告)号:US20230159447A1
公开(公告)日:2023-05-25
申请号:US17801109
申请日:2021-03-03
申请人: Arkema France , Centre National De La Recherche Scientifique - CNRS , Universite d'AIX-Marseille
IPC分类号: C07C315/02 , C12P11/00 , C07C315/06
CPC分类号: C07C315/02 , C07C315/06 , C12P11/00
摘要: Chemoenzymatic process for coproducing a disulfide and a sulfoxide or a sulfone The present invention relates to a chemoenzymatic process for coproducing disulfide and sulfoxide or sulfone from a composition M comprising: 1) a sulfide, 2) optionally an oxidizing agent, 3) an organic compound bearing at least one thiol group, 4) an enzyme E catalyzing the oxidation of said sulfide to sulfoxide or to sulfone, 5) an enzyme D catalyzing the formation of a disulfide bridge between two equivalents of said organic compound bearing at least one thiol group to form a dimer, and 6) a cofactor common to the two enzymes E and D; and also to a composition enabling especially the implementation of this process. The present invention also relates to the use of a mercaptan for reducing a disulfide bridge formed between two equivalents of an organic compound bearing at least one thiol group, and more particularly to the use thereof as regeneration substrate of the process described above.
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公开(公告)号:US11635367B2
公开(公告)日:2023-04-25
申请号:US16063652
申请日:2016-12-16
申请人: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DU MANS
IPC分类号: G01N21/01 , G01N33/543 , G02B1/11 , G01N21/552 , G01N21/64 , G01N21/65
摘要: A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength λ through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n3 of which is lower than that of the refractive index n0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.
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公开(公告)号:US20230121377A1
公开(公告)日:2023-04-20
申请号:US18067120
申请日:2022-12-16
申请人: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
摘要: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C. in the presence of at least one amine reactant selected from among hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof; b) drying the gel obtained during step a) so as to obtain a sol-gel matrix containing at least one amine reactant.
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公开(公告)号:US11622978B2
公开(公告)日:2023-04-11
申请号:US16747198
申请日:2020-01-20
申请人: INSTITUT CURIE , Institut National de la Sante et da la Recherche Medicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人: Sebastian Amigorena , Eliane Piaggio , Christel Goudot , Luigia Pace , Genevieve Almouzni , Leticia Niborski
IPC分类号: A61K35/17 , A61P35/02 , C07K14/725 , C07K14/705 , A61K45/06
摘要: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.
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58.
公开(公告)号:US20230087997A1
公开(公告)日:2023-03-23
申请号:US17997153
申请日:2021-04-26
申请人: SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人: Guillaume RENAUD
IPC分类号: A61B8/08
摘要: Disclosed is a method for characterising an object, comprising: emission of ultrasonic waves that enter an object by passing through an external interface, then reflect off an internal interface, then exit the object by passing through the external interface again, the ultrasonic waves comprising first waves having a mode that varies according to a first variation during their propagation in the object, and second waves having a mode that varies according to a second variation during their propagation in the object; reception of echo signals comprising first signals representing echoes of the first waves, and second signals representing echoes of the second waves, construction of a plurality of images showing the object, the plurality of images being constructed from the echo signals, under the assumption that two characteristics of the object are equal to two candidate values, and comprising a first image constructed from the first signals, and a second constructed from the second signals; construction of a composite image from the plurality of images; calculation of a focus metric in the composite image and, depending on the metric, selection or not of the two candidate values as values of the two characteristics. These characteristics can be used, in particular, to estimate a thickness of the object between the two interfaces.
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公开(公告)号:US11609124B2
公开(公告)日:2023-03-21
申请号:US17487313
申请日:2021-09-28
申请人: UNIVERSITE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE
发明人: Marc Guillon , Gilles Tessier , Tengfei Wu , Pascal Berto
摘要: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation Δαij defined by Δαij=arccos, where “·” stands for the inner product between and .
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公开(公告)号:US11608315B2
公开(公告)日:2023-03-21
申请号:US16956201
申请日:2018-12-20
申请人: Arkema France , Université Lille 1—Sciences et Technologies , Centre National De La Recherche Scientifique—CNRS
IPC分类号: C07C319/06 , C01B32/77 , B01J21/06 , B01J23/28 , B01J35/10 , C07C319/02 , C07C321/04 , C01B32/70 , C07C319/28 , C07C319/14
摘要: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.
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