公开(公告)号：US20230100536A1

公开(公告)日：2023-03-30

申请号：US17802823

申请日：2021-02-26

Applicant: The Trustees of Princeton University

Inventor： Aaron Trowbridge ,  Ciaran Seath ,  David W.C. MacMillan

IPC: C07D213/22 ,  C07D213/56 ,  C07D213/79 ,  C07D401/14 ,  C07F15/00 ,  C09K11/06

Abstract: In one aspect, transition metal complexes are described herein having composition and electronic structure for generating reactive labeling intermediates having lifetimes and diffusion radii advantageous for proximity-based labeling of various biomolecular species, including proteins, in intracellular and intercellular environments.

公开(公告)号：US11583844B2

公开(公告)日：2023-02-21

申请号：US17167606

申请日：2021-02-04

Applicant: The Trustees of Princeton University

Inventor： Brad P Carrow ,  Liye Chen

IPC: B01J31/24 ,  C07F9/50 ,  C07B37/04 ,  B01J31/22 ,  C07F15/00 ,  C07F1/00 ,  C07F3/00

Abstract: In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.

公开(公告)号：US20230028572A1

公开(公告)日：2023-01-26

申请号：US17778135

申请日：2020-11-19

Applicant: The Trustees of Princeton University

Inventor： Maksym MEZHERICHER ,  Howard A. STONE

IPC: B05B17/04 ,  B65D83/28

Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.

公开(公告)号：US20220400375A1

公开(公告)日：2022-12-15

申请号：US17419895

申请日：2021-03-02

Applicant: The Trustees of Princeton University

Inventor： Paul Schmitt

IPC: H04W12/02 ,  H04W12/06 ,  H04W12/63 ,  H04W12/72 ,  H04W12/40

Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a next generation core (NGC). The NGC includes an authentication server function (AUSF) configured to determine whether the computing device contains a valid subscriber identity module (SIM) card, and a user plane function (UPF) configured to allow a computing device to connect to the Internet. The architecture further includes a gateway connected to the UPF, the gateway configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access.

公开(公告)号：US11481495B2

公开(公告)日：2022-10-25

申请号：US16410675

申请日：2019-05-13

Applicant: SRI International ,  The Trustees of Princeton University

Inventor： Sek M. Chai ,  Zecheng He ,  Aswin Nadamuni Raghavan ,  Ruby B. Lee

IPC: G06F21/56 ,  G06N7/00 ,  H04L9/40 ,  G06F11/34

Abstract: A method, apparatus and system for anomaly detection in a processor based system includes training a deep learning sequence prediction model using observed baseline behavioral sequences of at least one processor behavior of the processor based system, predicting baseline behavioral sequences from the observed baseline behavioral sequences using the sequence prediction model, determining a baseline reconstruction error distribution profile using the baseline behavioral sequences and the predicted baseline behavioral sequences, predicting test behavioral sequences from observed, test behavioral sequences using the sequence prediction model, determining a testing reconstruction error distribution profile using the observed test behavioral sequences and the predicted test behavioral sequences, and comparing the baseline reconstruction error distribution profile to the testing reconstruction error distribution profile to determine if an anomaly exists in a processor behavior of the processor based system.

公开(公告)号：US20220319636A1

公开(公告)日：2022-10-06

申请号：US17696069

申请日：2022-03-16

Applicant: The Trustees of Princeton University

Inventor： Dalton Conley

IPC: G16B20/40 ,  G16B20/20 ,  G16B40/00 ,  G16B50/00 ,  G16B30/00

Abstract: Disclosed is a method for calculating genetic score based on genotypic information that predicts plasticity in a phenotype. More particularly, disclosed is an algorithm to calculate a particular type of genetic score based on basic genotypic information that is provided by commercially available technologies ranging from “SNP-chips” to whole genome sequencing. Polygenic scores— attempts to summarize the genetic propensity for or risk of a given phenotype (i.e., disease or trait)—have been around for more than a decade. They aim to predict the level of a trait—i.e., how tall or short someone may be or what their blood pressure or BMI might be. The Variation Polygenic Score (“vPGS”) disclosed herein is different. Its purpose is not to predict whether someone who scores higher or lower on the vPGS will be, for instance, heavier or lighter or have a higher or lower IQ. Rather, it is formulated to predict variation. The disclosed vPGS does not predict the mean level but rather the dispersion around that mean. It likely also predicts individual changes in a phenotype over the lifecourse (e.g., whether an individual tends to fluctuate greatly in weight). The disclosed approach is very suited for gene-environment interaction studies: that is, it is a good measure of the genetic propensity to be influenced by the environment for or intervention on a particular trait, disease or other phenotype.

公开(公告)号：US20220291119A1

公开(公告)日：2022-09-15

申请号：US17689579

申请日：2022-03-08

Applicant: The Trustees of Princeton University

Inventor： Chu C. Teng ,  Gerard Wysocki

IPC: G01N21/31

Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.

公开(公告)号：US20220275027A1

公开(公告)日：2022-09-01

申请号：US17753299

申请日：2019-08-28

Applicant: TRUSTEES OF PRINCETON UNIVERSITY ,  ALBERT EINSTEIN COLLEGE OF MEDICINE

Inventor： TOM W. MUIR ,  ADAM STEVENS ,  JOSEF GRAMESPACHER ,  DAVID COWBURN ,  GIRIDHAR SEKAR

IPC: C07K14/00 ,  C07K1/02

Abstract: The present disclosure relates to atypical split N- and C-inteins and variants thereof. This disclosure also relates to complexes comprising the split N- or C-inteins of this disclosure and a compound of interest and compositions comprising said complexes. In addition, this disclosure relates to methods of using the atypical split N- and C-inteins.

公开(公告)号：US20220274098A1

公开(公告)日：2022-09-01

申请号：US17680556

申请日：2022-02-25

Applicant: EXXONMOBIL CHEMICAL PATENTS INC. ,  THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： ALEX E. CARPENTER ,  TZU-PIN LIN ,  IRENE C. CAI ,  GURSU CULCU ,  DANIELLE SINGLETON ,  PAUL J. CHIRIK ,  C. ROSE KENNEDY ,  MEGAN MOHADJER BEROMI

IPC: B01J37/04 ,  C07C2/30

Abstract: Methods for the hydroalkenylation of conjugated, 1,3-dienes using a diimine catalyst. The method comprises mixing a diene having at least five carbon atoms and an iron diimine complex at a temperature of about −60° C. to about 23° C. to provide a catalyst solution; and introducing one or more alpha olefins at a pressure of at least 300 psig to obtain a product comprising the substituted diene monomer.

公开(公告)号：US20220240864A1

公开(公告)日：2022-08-04

申请号：US17619449

申请日：2020-06-16

Applicant: The Trustees of Princeton University

Inventor： Hongxu Yin ,  Bilal Mukadam ,  Xiaoliang Dai ,  Niraj K. Jha

IPC: A61B5/00 ,  G06N3/04 ,  A61B5/0205 ,  G06N3/08

Abstract: According to various embodiments, a machine-learning based system for diabetes analysis is disclosed. The system includes one or more processors configured to interact with a plurality of wearable medical sensors (WMSs). The processors are configured to receive physiological data from the WMSs and demographic data from a user interface. The processors are further configured to train at least one neural network based on a grow-and-prune paradigm to generate at least one diabetes inference model. The neural network grows at least one of connections and neurons based on gradient information and prunes away at least one of connections and neurons based on magnitude information. The processors are also configured to output a diabetes-based decision by inputting the received physiological data and demographic data into the generated diabetes inference model.