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公开(公告)号：US20170042818A1
公开(公告)日：2017-02-16
申请号：US15243234
申请日：2016-08-22
Inventor： Robert K. PRUD'HOMME , Patrick J. SINKO , Howard A. STONE , Nathalie M. PINKERTON , Lei SHI , Jiandi WAN , Sherif IBRAHIM , Dayuan GAO
IPC: A61K9/16 , A61K31/4745
CPC classification number: A61K9/1641 , A61K9/0019 , A61K9/1635 , A61K9/1647 , A61K31/437 , A61K31/4745
Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.
Abstract translation: 美国癌症协会估计，在2009年，美国将诊断出1,479,350例新的癌症病例，其中219,440例与肺和支气管有关。 NSCLC的标准治疗方法包括手术，化学疗法，放射线，激光和光动力疗法，均取决于癌症的各个阶段。 然而，国家癌症研究所评估标准治疗结果普遍较差，联合癌症阶段的5年生存率只有15％。 目前化疗药物面临的挑战包括对健康组织的过度毒性和预防转移的能力有限。 本文描述的双重药物递送系统选择性地靶向肺以递送抗癌药物并抑制转移的形成。
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公开(公告)号：US20230417640A1
公开(公告)日：2023-12-28
申请号：US18336266
申请日：2023-06-16
Applicant: Versitech Limited , THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor： Yuan LIU , Anderson, Ho Cheung SHUM , Janine K. NUNES , Howard A. STONE
CPC classification number: G01N3/068 , G01N3/08 , G01N2203/0075
Abstract: The subject invention pertains to a new method for measuring the elastic properties of microfibers by rope-coiling. Rope-coiling refers to the buckling of a slender elastic fiber caused by axial compression. A continuous flow microfluidic method enables the high-throughput measurement of the elasticity of microfibers by rope-coiling, where sample loading and unloading are not needed between consecutive measurements. In certain embodiments the coiling radius can be directly proportional to the elastic modulus of the fiber, facilitating calibration to measure fiber elasticity for high-throughput applications. Throughput can be thousands of times higher than that of a tensile tester, making possible an in situ, on-line measurement in a microfluidic production line, which couples the making of microfibers and the measurement of elasticity on the same line. The new method can also measure certain fibers with local variations in elasticity.
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公开(公告)号：US20230028572A1
公开(公告)日：2023-01-26
申请号：US17778135
申请日：2020-11-19
Applicant: The Trustees of Princeton University
Inventor： Maksym MEZHERICHER , Howard A. STONE
Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle. The generated aerosol particles are extremely light-weight (few micrograms) and have very small wall thickness (couple of microns), which enables precise delivery of materials and rapid evaporation of solvent in their liquid walls. The process production rate is easily scalable. In terms of possible applications, liquid used for aerosol generation can be enriched with suspended or dissolved materials, for instance by a medical drug for direct delivery into a patient's airways, or by organic/inorganic solvent which solidifies during drying enabling formation of soft or rigid spherical shells out of particles with liquid shells. The blowing gas can have suspended micron/nano particles in it and these particles will be encapsulated by liquid walls of formed micro-shells, which can potentially solidify during their motion, and thus produced aerosols can be used as transport agents for material delivery. Formation of fine monodisperse liquid or solid foams is possible by collecting liquid micro-shells from the generated aerosol on a surface or in a vessel, while the liquid walls of particles of adhere to each other and then can solidify due to solvent evaporation, freezing or polymerization.
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Patent Agency Ranking
4.发明公开公开(公告)号：US20230143042A1
公开(公告)日：2023-05-11
申请号：US17917598
申请日：2021-04-06
Applicant: The Trustees of Princeton University
Inventor： Maksym MEZHERICHER , Howard A. STONE
CPC classification number: A61K9/0075 , A61M16/14 , A61M11/02 , A61K35/76 , A61K9/1682 , A61K36/185 , A61K31/58
Abstract: Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.
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公开(公告)号：US20200326301A1
公开(公告)日：2020-10-15
申请号：US16915651
申请日：2020-06-29
Inventor： Jesse AULT , Sangwoo SHIN , Howard A. STONE , Jie FENG , Patrick WARREN
IPC: G01N27/447 , G01N15/14 , G01N15/00
Abstract: Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
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6.发明申请NOVEL DROPLET-EMBEDDED MICROFIBERS, AND METHODS AND DEVICES FOR PREPARING AND USING SAME 审中-公开新型滴灌微型纤维素，以及制备和使用它们的方法和装置公开(公告)号：US20170056331A1
公开(公告)日：2017-03-02
申请号：US14680710
申请日：2015-04-07
Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
Inventor： Howard A. STONE , Janine K. NUNES , Eujin UM , Tamara PICO
CPC classification number: A61K31/085 , A61K9/0092 , A61K9/5026 , A61K49/0043 , A61K49/0093 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/62
Abstract: The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber. The various phases comprised within the fiber can vary in terms of in terms of hydrophobic/hydrophilic character, solid/fluid, or gel crosslink density, which allows for the introduction of heterogeneous microenvironments within the fiber, each of which with distinct solubility characteristics, permeability, and mechanical properties. Various compounds and materials can be encapsulated in the different microcompartments of the fiber for storage and delivery applications, as well as to provide multifunctionality to the fiber structure. The disclosed structures have a broad range of potential applications, for example as engineered substrates with controlled release profiles of multiple compounds for tissue engineering (such as a tissue scaffold, for example) and bioengineering applications.
Abstract translation: 本发明包括微流体方法和装置，其允许连续生产具有沿特定位置的纤维长度对齐的嵌入液滴的微纤维。 本发明允许在纤维内形成单个或多个乳液。 包含在纤维中的各种相可以根据疏水性/亲水特性，固体/流体或凝胶交联密度而变化，这允许在纤维内引入异质微环境，其中每一种具有不同的溶解度特性，渗透性 ，和机械性能。 可以将各种化合物和材料包封在纤维的不同微型隔室中用于储存和递送应用，以及为纤维结构提供多功能性。 所公开的结构具有广泛的潜在应用，例如作为具有用于组织工程的多种化合物（例如组织支架）和生物工程应用的受控释放特征的工程化基底。
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公开(公告)号：US20220268731A1
公开(公告)日：2022-08-25
申请号：US17720687
申请日：2022-04-14
Inventor： Jesse AULT , Sangwoo SHIN , Howard A. STONE , Jie FENG , Patrick WARREN
IPC: G01N27/447 , G01N15/14 , G01N15/00
Abstract: Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
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公开(公告)号：US20200255299A1
公开(公告)日：2020-08-13
申请号：US16330701
申请日：2017-09-01
Applicant: The Trustees of Princeton University
Inventor： Howard A. STONE , Orest Shardt , Sangwoo Shin , Patrick B. Warren
Abstract: Disclosed is a separation device and a method for separating charged particles from a liquid stream. The separation is effected by establishing an ion concentration gradient across the direction of the liquid stream by the introduction of a gas which when contacted with the liquid, in a reversible reaction, forms a soluble ionic species. A concentration gradient is maintained across the direction of the liquid stream which in turn induces separation of charged particles within the liquid stream due to the effect of diffusiophoresis. The device operates using little or no power, and dispenses with the need for filtration media or separation membranes. The device and method is adaptable to any of a number of separation processes, including biological separation processes, water purification and industrial processes.
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