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51.发明申请公开(公告)号：US20210282709A1
公开(公告)日：2021-09-16
申请号：US16317966
申请日：2017-06-07
发明人： David Ledden
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61K31/192 , A61K31/573 , A61K31/722 , A61K31/616 , A61K9/00
摘要： Devices, kits, and methods for (a) determining the presence and/or concentration of at least one analyte(s) of interest present in a patient's fluid sample and devices and methods of calibration related thereto, and (b) preventing, mitigating, and/or eliminating biofouling of an indwelling, wearable biosensor are disclosed and/or claimed herein.
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公开(公告)号：US20210247399A1
公开(公告)日：2021-08-12
申请号：US17250675
申请日：2019-09-19
发明人： Tie Wei
摘要： Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of biotin and at least one target analyte in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths.
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公开(公告)号：US20210231642A1
公开(公告)日：2021-07-29
申请号：US17226464
申请日：2021-04-09
发明人： Michael S. Wilson , Jay Li , Kenneth P. Galano
IPC分类号： G01N33/49
摘要： A plasma separation system and process for providing filtered plasma from a blood sample is described. The system may include a blood separation well having a separation membrane for filtering the blood sample. The filtering process may be aided by the use of a negative or positive pressure source attached to the plasma separation system.
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公开(公告)号：US20210230119A1
公开(公告)日：2021-07-29
申请号：US17250131
申请日：2019-06-25
发明人： Anand Natrajan
IPC分类号： C07D219/06
摘要： The present invention provides compounds used in the synthesis of chemiluminescent acridinium compounds and methods of producing these compounds. Specifically, methods are provided for the N-alkylation of acridan compounds using alkylating reagents. Typically, these alkylating reagents comprise a protected sulfonate group protected with an acid-labile protecting group.
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公开(公告)号：US20210223087A1
公开(公告)日：2021-07-22
申请号：US16095904
申请日：2017-05-10
摘要： Embodiments are directed to a simple, tool-less, and automated connection between a transfer probe and a capacitive liquid level detection printed circuit assembly (PCA) for use in a clinical analyzer in an in vitro diagnostics (IVD) environment in a hospital or laboratory setting. Advantageously, a single user connection is required: a fitting that is used to attach fluid tubing of the transfer arm to a probe, resulting in a mechanical, fluid, and electrical connection between the probe and the transfer arm. A PCA comprises a plurality of spring-loaded pins and capacitive liquid level detection circuity. A probe comprises a primary tube nested within a secondary tube, wherein the primary tube and the secondary tube comprise respective heads at respective top portions thereof forming a set of electrically isolated surfaces. The fitting secures the probe within a transfer arm and establishes the connection between the PCA and the probe.
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公开(公告)号：US11066710B2
公开(公告)日：2021-07-20
申请号：US16275596
申请日：2019-02-14
发明人： Michael Stürzl , Roland S. Croner , Andreas Konrad
IPC分类号： C12Q1/68 , G01N33/574 , G16H50/30 , C12Q1/6886
摘要： The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.
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57.发明申请公开(公告)号：US20210217190A1
公开(公告)日：2021-07-15
申请号：US17059420
申请日：2019-05-16
发明人： Thomas Engel , Gabriele Hörnig , Gaby Marquardt , Lukas Richter
摘要： The invention relates to an analyzer for analyzing a medical sample. The analyzer comprises an optical microscope for imaging a light field in an object region in order to image the sample. The microscope comprises a light source for illuminating the sample, an objective comprising a converging lens for concentrating and focusing light beams coming from the illuminated sample, and a digital recording device for recording the light beams. A light-field camera for capturing the light field from the object region, which light field is imaged in the microscope, is provided on the microscope.
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58.发明申请公开(公告)号：US20210201151A1
公开(公告)日：2021-07-01
申请号：US17265476
申请日：2019-07-29
摘要： To train a machine learning routine (BNN), a sequence of first training data (PIC) is read in through the machine learning routine. The machine learning routine is trained using the first training data, wherein a plurality of learning parameters (LP) of the machine learning routine is set by the training. Furthermore, a value distribution (VLP) of the learning parameters, which occurs during the training, is determined and a continuation signal (CN) is generated on the basis of the determined value distribution of the learning parameters. Depending on the continuation signal, the training is then continued with a further sequence of the first training data or other training data (PIC2) are requested for the training.
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公开(公告)号：US11020743B2
公开(公告)日：2021-06-01
申请号：US16968717
申请日：2019-02-13
发明人： Aaron Kauffmann
摘要： Devices, kits, and methods for conducting a plurality of diagnostic assays on a patient's single liquid test sample within a single reaction cassette.
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公开(公告)号：US20210133971A1
公开(公告)日：2021-05-06
申请号：US17251744
申请日：2019-06-10
发明人： Kai Ma , Yao-Jen Chang , Terrence Chen , Benjamin S. Pollack
摘要： A method of characterizing a serum or plasma portion of a specimen in a specimen container provides a fine-grained HILN index (hemolysis, icterus, lipemia, normal) of the serum or plasma portion of the specimen, wherein the H, I, and L classes may each have five to seven sub-classes. The HILN index may also have one un-centrifuged class. Pixel data of an input image of the specimen container may be processed by a deep semantic segmentation network having, in some embodiments, more than 100 layers. A small front-end container segmentation network may be used to determine a container type and boundary, which may additionally be input to the deep semantic segmentation network. A discriminative network may be used to train the deep semantic segmentation network to generate a homogeneously structured output. Quality check modules and testing apparatus configured to carry out the method are also described, as are other aspects.
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