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    IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS
    51.
    发明申请
    IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS 有权

    公开(公告)号：US20210238181A1

    公开(公告)日：2021-08-05

    申请号：US17049232

    申请日：2019-04-22

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： Webster L. SANTOS ,  Yumin DAI ,  Jose A. SANTIAGO-RIVERA ,  Jacob H. MURRAY

    IPC: C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  A61P3/04

    Abstract: The disclosure provides compounds of Formula (I-A) and (I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula (I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH), Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formulae (I-A) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.

    THREE-DIMENSIONAL PIEZOELECTRIC MATERIALS AND USES THEREOF
    52.
    发明申请
    THREE-DIMENSIONAL PIEZOELECTRIC MATERIALS AND USES THEREOF 有权

    公开(公告)号：US20210234089A1

    公开(公告)日：2021-07-29

    申请号：US17057715

    申请日：2019-05-24

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： Xiaoyu ZHENG ,  Huachen CUI ,  Ryan HENSLEIGH

    IPC: H01L41/18 ,  H01L41/04 ,  H01L41/39 ,  H01L41/45 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y80/00

    Abstract: Described herein are aspects of a three-dimensional (3D) piezoelectric structure that can be composed of a 3D periodic microlattice that can be composed of a piezoelectric composite material, wherein the 3D periodic microlattice can include a plurality of interconnected 3D node units capable of generating a piezoelectric response upon application of a stress to the 3D periodic microlattice, and wherein the plurality of interconnected 3D node units can form a tailored piezoelectric tensor space. Also described herein are systems that can include one or more of the 3D piezoelectric structures described herein. Also described herein are methods of making and using the 3D piezoelectric structures described herein.

    LEARNING AND DEPLOYING COMPRESSION OF RADIO SIGNALS
    57.
    发明申请
    LEARNING AND DEPLOYING COMPRESSION OF RADIO SIGNALS 审中-公开

    公开(公告)号：US20200265338A1

    公开(公告)日：2020-08-20

    申请号：US16798490

    申请日：2020-02-24

    Applicant: Virginia Tech Intellectual Properties, Inc.

    Inventor： Timothy James O`Shea

    IPC: G06N20/00 ,  G06N3/08 ,  G06N3/04 ,  H04W24/08

    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned compact representations of radio frequency (RF) signals. One of the methods includes: determining a first RF signal to be compressed; using an encoder machine-learning network to process the first RF signal and generate a compressed signal; calculating a measure of compression in the compressed signal; using a decoder machine-learning network to process the compressed signal and generate a second RF signal that represents a reconstruction of the first RF signal; calculating a measure of distance between the second RF signal and the first RF signal; and updating at least one of the encoder machine-learning network or the decoder machine-learning network based on (i) the measure of distance between the second RF signal and the first RF signal, and (ii) the measure of compression in the compressed signal.

    Cleaning and Dewatering Fine Coal
    60.
    发明申请
    Cleaning and Dewatering Fine Coal 审中-公开

    公开(公告)号：US20200179941A1

    公开(公告)日：2020-06-11

    申请号：US16788617

    申请日：2020-02-12

    Applicant: Virginia Tech Intellectual Properties, Inc.

    Inventor： Roe-Hoan Yoon ,  Mert Kerem Eraydin

    IPC: B03B9/00 ,  C10L9/10 ,  C10L5/36 ,  B03B1/04

    Abstract: Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.

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