公开(公告)号：US20090092645A1

公开(公告)日：2009-04-09

申请号：US11867701

申请日：2007-10-05

申请人： Te-Hsing Wu ,  Bin Lin ,  Nini-Chen Tsai ,  Chia-Chieh Chen ,  Lie-Hang Shen ,  Wuu-Jyh Lin

发明人： Te-Hsing Wu ,  Bin Lin ,  Nini-Chen Tsai ,  Chia-Chieh Chen ,  Lie-Hang Shen ,  Wuu-Jyh Lin

IPC分类号： A61K9/70 ,  A61P31/04

CPC分类号： A61L15/14 ,  A61K9/10 ,  A61K47/02 ,  A61L15/46 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  D06M10/008 ,  D06M10/06 ,  D06M11/65 ,  D06M11/79 ,  D06M11/83 ,  D06M16/00 ,  D06M23/08 ,  D06M2101/32 ,  D06M2101/34

摘要： The invention discloses an innovative process to produce highly antibacterial nano-composite fabric textile containing silver metal compound. The process mainly uses high-energy D-ray radiation to modify silver type of bactericides and graft or crosslink them onto Nylon or PET fiber surface to produce excellent antibacterial textile products. The mechanism uses silver nano-compound as performance additive and through Co-60 irradiation technique reduces and firmly fastens silver particles onto Nylon or PET (Polyethylene Terephthalate) fiber material. Because the inorganic silver type bactericides actively interact with enzymes in bacteria or destroy cell walls to achieve good bactericidal effect, the radiation process does not need initiators or other additives. So the process is simple and effective. The test results prove excellent bactericidal power and potential value in household or medical textile products.

摘要翻译： 本发明公开了一种生产含有银金属化合物的高抗菌纳米复合织物织物的创新方法。 该方法主要采用高能D射线辐射法改性银类杀菌剂，并将其接枝或交联到尼龙或PET纤维表面，生产出优良的抗菌纺织品。 该机理采用银纳米复合材料作为性能添加剂，通过Co-60辐照技术可将银粒子还原并牢固地固定在尼龙或PET（聚对苯二甲酸乙二醇酯）纤维材料上。 由于无机银型杀菌剂与细菌中的酶积极相互作用或破坏细胞壁以达到良好的杀菌效果，所以辐射过程不需要引发剂或其他添加剂。 所以这个过程很简单有效。 测试结果证明了家用或医用纺织品的优良杀菌力和潜在价值。

公开(公告)号：US20080241063A1

公开(公告)日：2008-10-02

申请号：US11727996

申请日：2007-03-29

申请人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

发明人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

IPC分类号： A61K51/00 ,  C07C279/02

CPC分类号： A61K51/0406 ,  A61K51/1282 ,  C07C279/06

摘要： The present invention relates to a combination set of meta-iodobenzyl guanidine (MIBG) freezing crystal and making method thereof and method of radioactive marker for making. The combination set of freezing crystal includes a first container having freezing crystal and a second container having sodium acetate buffer solution. The method for making a combination set of freezing crystal includes the steps of mixing (meta-iodobenzyl guanidine)2·sulfuric acid and ammonium sulfate into first non-pyrogenic injection water; getting a first container having freezing crystal after freezing and drying; and getting a second container having the sodium acetate buffer solution after sterilizing. The method of radioactive marker for making includes the steps of adding radioactive iodine ion into freezing crystal to react and adding sodium acetate buffer solution to get radioactive MIBG solution. The present invention adjusts agent easily and is instant to use so the radioactive iodine marker don't lose activity easily before using it.

摘要翻译： 本发明涉及一种间碘碘苄基胍（MIBG）冷冻结晶的组合及其制备方法和放射性标记物的制备方法。 冷冻结晶组合包括具有冷冻晶体的第一容器和具有乙酸钠缓冲溶液的第二容器。 制备冷冻结晶组合的方法包括将（间碘碘苄基胍）亚磺酸和硫酸铵混合到第一非致热性注射水中的步骤; 在冷冻和干燥后得到具有冷冻晶体的第一容器; 并在灭菌后得到具有乙酸钠缓冲溶液的第二容器。 放射性标记物的制备方法包括将放射性碘离子加入冷冻结晶反应并加入乙酸钠缓冲溶液，得到放射性MIBG溶液的步骤。 本发明容易调节剂并且即时使用，所以放射性碘标记物在使用前不容易失去活性。

公开(公告)号：US20070258885A1

公开(公告)日：2007-11-08

申请号：US11429194

申请日：2006-05-08

申请人： Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

发明人： Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

IPC分类号： A61N5/00 ,  A61K51/00

CPC分类号： G21G4/08 ,  A61K51/1282 ,  G21H5/02

摘要： A device for concentrating 99mTc pertechnetate and a method thereof are disclosed. The device includes a concentration device, a control device and a central processing unit. The concentration device is for concentrating 99mTc pertechnetate, the control device connects with each members of the concentration device, and the central processing unit is used for saving an automatic control program. The automatic control program is run by the central processing unit so as to detect and monitor weight as well as activity of the concentrated 99mTc pertechnetate. Due to the automatical control, the concentration quality and production efficiency of the 99mTc pertechnetate are improved. Moreover, the radiation dose received by users is reduced.

摘要翻译： 公开了一种用于浓缩超高锝酸盐99m Tc的装置及其方法。 该装置包括集中装置，控制装置和中央处理装置。 浓缩装置用于浓缩高碘酸钠99m Tc，控制装置与浓缩装置的每个构件连接，中央处理单元用于保存自动控制程序。 自动控制程序由中央处理单元运行，以便检测和监测浓缩的99m Tc高温酸盐的重量以及活性。 由于自动控制，提高了99m Tc高锝酸盐的浓度质量和生产效率。 此外，用户接收的辐射剂量减少。

公开(公告)号：US07138540B1

公开(公告)日：2006-11-21

申请号：US11162287

申请日：2005-09-06

申请人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu

发明人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu

IPC分类号： C07C229/36

CPC分类号： C07C227/20 ,  C07C269/06 ,  Y02P20/55 ,  C07C229/36 ,  C07C271/22

摘要： This is a new precursor and new method for the synthesis of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1 is a protective group for the carboxyl functional group, R2 is a protective group for the amino group, and R3 acts as a leaving group. R1 represents an arylalkyl group, R2 represents a carboxyl group, and R3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, the invention includes a method for the syntheses of new precursors with the chemical structures as in Formula 1.

摘要翻译： 这是合成无载体添加的O-（2 - [[18 F] F]氟乙基）-L-酪氨酸的新的前体和新方法，已被证明是合适的PET（位置发射断层扫描 ）探针用于肿瘤诊断成像，标题化合物的制备从具有式1化学结构的前体开始，其中R 1是羧基官能团的保护基，R 2 作为氨基的保护基，R 3 3作为离去基团。 R 1表示芳基烷基，R 2表示羧基，R 3表示对甲苯磺酰氧基，甲磺酰氧基或三氟甲磺酰氧基或 溴，本发明包括用于合成具有式1化学结构的新前体的方法。

公开(公告)号：US07132563B1

公开(公告)日：2006-11-07

申请号：US11162286

申请日：2005-09-06

申请人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu ,  Mao Hsiung Chang

发明人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu ,  Mao Hsiung Chang

IPC分类号： C07C229/36

CPC分类号： C07C227/20 ,  C07C269/06 ,  Y02P20/55 ,  C07C229/36 ,  C07C271/22

摘要： This is a novel method for production of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine, which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, and the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1 is a protective group for the carboxyl functional group, R2 is a protective group for the amino group, and R3 acts as a leaving group, R1 represents an arylalkyl group, R2 represents a carboxyl group, and R3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, and the final purification of the product is using a separation column, which is very convenient for automated synthesis, and the invention uses the precursor with the chemical structures as in Formula 1.

摘要翻译： 这是一种生产无载体添加的O-（2- [叔丁基]氟乙基）-L-酪氨酸的新方法，已被证明是合适的PET（位置发射断层摄影）探针， 肿瘤诊断成像和标题化合物的制备从具有式1化学结构的前体开始，其中R 1是羧基官能团的保护基，R 2， SUP>是氨基的保护基，R 3 3作为离去基团，R 1表示芳基烷基，R 2， 表示羧基，R 3表示对甲苯磺酰氧基，甲磺酰氧基或三氟甲磺酰氧基或溴，产物的最终纯化是使用分离柱，这对于自动合成非常方便， 本发明使用具有式1化学结构的前体。