公开(公告)号：US07556780B1

公开(公告)日：2009-07-07

申请号：US11518442

申请日：2006-09-11

申请人： Ai-Ren Lo ,  Chia-Chieh Chen ,  Tseng-Chung Huang ,  Hung-Chun Kao

发明人： Ai-Ren Lo ,  Chia-Chieh Chen ,  Tseng-Chung Huang ,  Hung-Chun Kao

IPC分类号： B01J19/00

CPC分类号： B01J19/004 ,  B01J2219/00286 ,  B01J2219/00409 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00756 ,  B01J2219/00759 ,  C07B59/001 ,  C07C319/20 ,  C07C323/37

摘要： A manufacturing method for 123I-ADAM and an automatic manufacturing device thereof are disclosed. The manufacturing process for 123I-ADAM consists of four steps-add [123I] ammonium iodide solution, make oxidation reaction occur, terminate the reaction and neutralize the solution, filter and collect the filtrate. The automatic manufacturing device includes a plurality of units for taking each of the four steps that is disposed inside a chassis and is operated by automatic control. Users only need to put reactants into storage bottles respectively, turn on the power, and initiate the operation system, Then the preparation process of drugs for clinical diagnosis is finished within twenty minutes.

摘要翻译： 公开了一种123I-ADAM的制造方法及其自动制造装置。 123I-ADAM的制备方法由四步法组成 - 加入[123 I]碘化铵溶液，发生氧化反应，终止反应并中和溶液，过滤收集滤液。 自动制造装置包括多个单元，用于将四个步骤中的每一个设置在底盘内并通过自动控制操作。 用户只需要将反应物分别放入储存瓶中，打开电源，启动操作系统，然后在二十分钟内完成临床诊断药物的制备过程。

公开(公告)号：US20070258885A1

公开(公告)日：2007-11-08

申请号：US11429194

申请日：2006-05-08

申请人： Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

发明人： Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

IPC分类号： A61N5/00 ,  A61K51/00

CPC分类号： G21G4/08 ,  A61K51/1282 ,  G21H5/02

摘要： A device for concentrating 99mTc pertechnetate and a method thereof are disclosed. The device includes a concentration device, a control device and a central processing unit. The concentration device is for concentrating 99mTc pertechnetate, the control device connects with each members of the concentration device, and the central processing unit is used for saving an automatic control program. The automatic control program is run by the central processing unit so as to detect and monitor weight as well as activity of the concentrated 99mTc pertechnetate. Due to the automatical control, the concentration quality and production efficiency of the 99mTc pertechnetate are improved. Moreover, the radiation dose received by users is reduced.

摘要翻译： 公开了一种用于浓缩超高锝酸盐99m Tc的装置及其方法。 该装置包括集中装置，控制装置和中央处理装置。 浓缩装置用于浓缩高碘酸钠99m Tc，控制装置与浓缩装置的每个构件连接，中央处理单元用于保存自动控制程序。 自动控制程序由中央处理单元运行，以便检测和监测浓缩的99m Tc高温酸盐的重量以及活性。 由于自动控制，提高了99m Tc高锝酸盐的浓度质量和生产效率。 此外，用户接收的辐射剂量减少。

公开(公告)号：US07138540B1

公开(公告)日：2006-11-21

申请号：US11162287

申请日：2005-09-06

申请人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu

发明人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu

IPC分类号： C07C229/36

CPC分类号： C07C227/20 ,  C07C269/06 ,  Y02P20/55 ,  C07C229/36 ,  C07C271/22

摘要： This is a new precursor and new method for the synthesis of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1 is a protective group for the carboxyl functional group, R2 is a protective group for the amino group, and R3 acts as a leaving group. R1 represents an arylalkyl group, R2 represents a carboxyl group, and R3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, the invention includes a method for the syntheses of new precursors with the chemical structures as in Formula 1.

摘要翻译： 这是合成无载体添加的O-（2 - [[18 F] F]氟乙基）-L-酪氨酸的新的前体和新方法，已被证明是合适的PET（位置发射断层扫描 ）探针用于肿瘤诊断成像，标题化合物的制备从具有式1化学结构的前体开始，其中R 1是羧基官能团的保护基，R 2 作为氨基的保护基，R 3 3作为离去基团。 R 1表示芳基烷基，R 2表示羧基，R 3表示对甲苯磺酰氧基，甲磺酰氧基或三氟甲磺酰氧基或 溴，本发明包括用于合成具有式1化学结构的新前体的方法。

公开(公告)号：US07132563B1

公开(公告)日：2006-11-07

申请号：US11162286

申请日：2005-09-06

申请人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu ,  Mao Hsiung Chang

发明人： Jenn Tzong Chen ,  Wuu Jyh Lin ,  Ai Ren Lo ,  Ming Hsin Lee ,  Hsin Er Wang ,  Shih Yan Wu ,  Mao Hsiung Chang

IPC分类号： C07C229/36

CPC分类号： C07C227/20 ,  C07C269/06 ,  Y02P20/55 ,  C07C229/36 ,  C07C271/22

摘要： This is a novel method for production of no-carrier-added O-(2-[18F]fluoroethyl)-L-Tyrosine, which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, and the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1 is a protective group for the carboxyl functional group, R2 is a protective group for the amino group, and R3 acts as a leaving group, R1 represents an arylalkyl group, R2 represents a carboxyl group, and R3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, and the final purification of the product is using a separation column, which is very convenient for automated synthesis, and the invention uses the precursor with the chemical structures as in Formula 1.

摘要翻译： 这是一种生产无载体添加的O-（2- [叔丁基]氟乙基）-L-酪氨酸的新方法，已被证明是合适的PET（位置发射断层摄影）探针， 肿瘤诊断成像和标题化合物的制备从具有式1化学结构的前体开始，其中R 1是羧基官能团的保护基，R 2， SUP>是氨基的保护基，R 3 3作为离去基团，R 1表示芳基烷基，R 2， 表示羧基，R 3表示对甲苯磺酰氧基，甲磺酰氧基或三氟甲磺酰氧基或溴，产物的最终纯化是使用分离柱，这对于自动合成非常方便， 本发明使用具有式1化学结构的前体。

公开(公告)号：US20090169439A1

公开(公告)日：2009-07-02

申请号：US11518442

申请日：2006-09-11

申请人： Ai-Ren Lo ,  Chia-Chieh Chen ,  Tseng-Chung Huang ,  Hung-Chun Kao

发明人： Ai-Ren Lo ,  Chia-Chieh Chen ,  Tseng-Chung Huang ,  Hung-Chun Kao

IPC分类号： B01J19/00

CPC分类号： B01J19/004 ,  B01J2219/00286 ,  B01J2219/00409 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00756 ,  B01J2219/00759 ,  C07B59/001 ,  C07C319/20 ,  C07C323/37

摘要： A manufacturing method for 123I-ADAM and an automatic manufacturing device thereof are disclosed. The manufacturing process for 123I-ADAM consists of four steps-add [123I] ammonium iodide solution, make oxidation reaction occur, terminate the reaction and neutralize the solution, filter and collect the filtrate. The automatic manufacturing device includes a plurality of units for taking each of the four steps that is disposed inside a chassis and is operated by automatic control. Users only need to put reactants into storage bottles respectively, turn on the power, and initiate the operation system, Then the preparation process of drugs for clinical diagnosis is finished within twenty minutes.

摘要翻译： 公开了一种123I-ADAM的制造方法及其自动制造装置。 123I-ADAM的制备方法由四步法组成 - 加入[123 I]碘化铵溶液，发生氧化反应，终止反应并中和溶液，过滤收集滤液。 自动制造装置包括多个单元，用于将四个步骤中的每一个设置在底盘内并通过自动控制操作。 用户只需要将反应物分别放入储存瓶中，打开电源，启动操作系统，然后在二十分钟内完成临床诊断药物的制备过程。

公开(公告)号：US20050255010A1

公开(公告)日：2005-11-17

申请号：US10846658

申请日：2004-05-17

申请人： Ai-Ren Lo ,  Bor-Tsung Hsieh ,  Tseng-Chung Huang ,  Tsai-Yueh Luo

发明人： Ai-Ren Lo ,  Bor-Tsung Hsieh ,  Tseng-Chung Huang ,  Tsai-Yueh Luo

IPC分类号： B32B5/02

CPC分类号： G21G7/00 ,  A61N5/1002

摘要： An apparatus includes: a fully automated concentrator for 188Re-Perrhenate solution, a control box, and a control computer. The concentrator is controlled by the control box which obtains the signals from the computer. The operator can control it from far away, and monitor the processes such as liquid transfer, washing, filtration, collection etc. from a monitor for the computer. The apparatus can measure the radioactive activities of the collected concentrated 188Re-perrhenate solution and waste during operation; and can also measure the weights of the collecting bottle and solution. Hence the product quality and working efficiency can be increased, and radiation absorbed dose of an operator can be reduced.

摘要翻译： 一种装置包括：用于 188重新鉴定溶液的全自动浓缩器，控制箱和控制计算机。 集中器由控制箱控制，该控制箱从计算机获取信号。 操作员可以从远处控制，并从计算机的显示器监控液体转移，洗涤，过滤，收集等过程。 该装置可以测量收集的浓缩的高铼酸盐溶液和废物在运行过程中的放射性活性; 并且还可以测量收集瓶和溶液的重量。 因此，可以提高产品质量和工作效率，并且可以减少操作者的辐射吸收剂量。