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    Methods and Devices for Treating a Bodily Lumen with In Situ Generated Structural Support
    53.
    发明申请
    Methods and Devices for Treating a Bodily Lumen with In Situ Generated Structural Support 审中-公开
    用原位生成的结构支持治疗身体的方法和装置

    公开(公告)号：US20150305892A1

    公开(公告)日：2015-10-29

    申请号：US14262516

    申请日：2014-04-25

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Syed Hossainy ,  Krishna Sudhir ,  John Stankus ,  Mikael Trollsas

    IPC: A61F2/50 ,  A61L31/04 ,  A61L31/06 ,  A61F2/82 ,  A61L31/14

    CPC classification number: A61F2/50 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L2300/624 ,  A61L2400/06 ,  A61L2400/12 ,  C08L67/04 ,  C08L71/02

    Abstract: A bodily lumen, such as a blood vessel, can be treated by forming a structural support in situ within the bodily lumen. This can be done by ejecting a formulation that includes a polymer that solidifies over a period of time, such as due to DMSO exchange or photocrosslinking. This can also be done by cooling a formulation until it freezes in situ. The structural support can also be made from a plaque which is already present in the bodily lumen. The plaque can be compressed by a balloon catheter and cooled so that it hardens and thereby forms the structural support. The bodily lumen can also be treated using a preformed structural support made of ice, for example frozen isotonic saline, or a fast degrading polymer, such as PEG. The preformed support is created outside of the bodily lumen, and then transported on a catheter to the treatment zone.

    Abstract translation: 可以通过在体腔内原位形成结构支架来治疗诸如血管的体腔。 这可以通过喷射包括在一段时间内固化的聚合物的制剂来实现，例如由于DMSO交换或光致交联。 这也可以通过冷却制剂直到其原位冻结来完成。 结构支撑物也可以由已经存在于体腔中的斑块制成。 斑块可以通过气囊导管压缩并冷却，使得其硬化并由此形成结构支撑。 还可以使用由冰制成的预制结构支撑物例如冷冻等渗盐水或快速降解聚合物例如PEG来处理身体腔。 预先形成的支撑体在体腔外部产生，然后在导管上运送到治疗区域。

    Delivery of Biologic Therapeutics
    57.
    发明申请
    Delivery of Biologic Therapeutics 有权
    交付生物治疗

    公开(公告)号：US20140186446A1

    公开(公告)日：2014-07-03

    申请号：US14142651

    申请日：2013-12-27

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Mikael Trollsas ,  John Stankus ,  James Su ,  Syed Hossainy ,  Joshua Takeshi Smith ,  Shadid Askar

    IPC: A61K9/14 ,  A61K38/19 ,  A61K38/21 ,  C07K16/18

    CPC classification number: A61K9/146 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K38/215 ,  A61K47/10 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/40 ,  C07K2317/21

    Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.

    Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。

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