公开(公告)号：US4980455A

公开(公告)日：1990-12-25

申请号：US136712

申请日：1987-12-22

申请人： Masao Sakaguchi ,  Susumu Honda ,  Osamu Nishimura

发明人： Masao Sakaguchi ,  Susumu Honda ,  Osamu Nishimura

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/21 ,  A61P43/00 ,  C07H21/04 ,  C07K1/22 ,  C07K14/52 ,  C07K14/555 ,  C07K14/57 ,  C12N1/20 ,  C12P21/02 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91

CPC分类号： C07K14/57 ,  A61K38/00

摘要： The present invention provides a novel polypeptide which shows higher IFN-.gamma. activity than intact IFN-.gamma. and a method of producing the same.The polypeptides not only possess a remarkable antiviral activity, antitumor activity, immunopotentiating activity but also is highly stable, therefore, it can be used advantageously as pharmaceuticals.

公开(公告)号：US4946918A

公开(公告)日：1990-08-07

申请号：US266764

申请日：1988-11-03

申请人： Saburo Akiyama ,  Susumu Honda ,  Shin-ichi Akimoto ,  Tohru Yasukohchi

发明人： Saburo Akiyama ,  Susumu Honda ,  Shin-ichi Akimoto ,  Tohru Yasukohchi

IPC分类号： C08F222/00

CPC分类号： C08F222/00

摘要： A synthetic resin compatibilizer comprising a copolymer of a polyoxyalkylene derivative represented by general formula(I) with maleic anhydride, maleic acid, or a salt or an ester thereof ##STR1## where B represents a residue of a compound having from 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having from 2 to 18 carbon atoms; R.sup.1 represents an unsaturated hydrocarbon group having from 2 to 5 carbon atoms; R.sup.2 represents a hydrocarbon or acyl group having from 1 to 40 carbon atoms; a is from 0 to 1,000; b is from 0 to 1,000; c is from 0 to 1,000; l is from 1 to 8; m is from 0 to 2; and n is from 0 to 7; l+m+n=2 to 8; al+bm+cn=1 to 1,000, and m/(l+n).ltoreq.1/3.The synthetic resin compatibilizer provides a polymer alloy having excellent tensile and flexural strengths.

公开(公告)号：US4946904A

公开(公告)日：1990-08-07

申请号：US193699

申请日：1988-05-13

申请人： Shin-ichi Akimoto ,  Susumu Honda ,  Tohru Yasukohchi

发明人： Shin-ichi Akimoto ,  Susumu Honda ,  Tohru Yasukohchi

IPC分类号： C04B24/04 ,  C04B24/26 ,  C04B24/32 ,  C04B103/30 ,  C08F290/14 ,  C08G65/26 ,  C08G65/332

CPC分类号： C08G65/2606 ,  C04B24/267 ,  C04B24/32 ,  C08F290/142 ,  C08G65/3322 ,  C04B2103/58

摘要： An additive for cement comprising, as the effective component, a copolymer of a polyoxyalkylene derivative represented by following formula (1) and maleic anhydride, a hydrolyzed product of the copolymer, or a salt of the hydrolyzed product; ##STR1## wherein Z represents a residue of a compound having a hydroxy group, said compound having from 2 to 8 carbon atoms; AO represents an oxyalkylene group having from 2 to 18 carbon atoms; X represents an unsaturated hydrocarbon group having from 2 to 5 carbon atoms or an unsaturated acyl group having from 2 to 5 carbon atoms; R represents hydrocarbon group having from 1 to 40 carbon atoms; a represents 0 to 1,000; b represents 0 to 1,000; c represents 0 to 1,000; l represents 1 to 7, m represents 0 to 2; and n represents 1 to 7; l+m+n=2 to 8, m/(l+n).ltoreq.1/2, and al+bm+cn.gtoreq.1.

公开(公告)号：US4681930A

公开(公告)日：1987-07-21

申请号：US639551

申请日：1984-08-10

申请人： Hsiang-Fu Kung ,  Hiromu Sugino ,  Susumu Honda

发明人： Hsiang-Fu Kung ,  Hiromu Sugino ,  Susumu Honda

IPC分类号： A61K38/00 ,  C07K1/113 ,  C07K14/57 ,  C07K15/26 ,  A61K45/02 ,  C12P21/00

CPC分类号： C07K1/1136 ,  C07K14/57 ,  A61K38/00 ,  Y10S435/811 ,  Y10S930/142

摘要： An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon.

摘要翻译： 公开了一种完整的人类免疫干扰素蛋白以及完整的重组人免疫干扰素的提取和纯化方法。 该方法允许纯化到完整的重组人免疫干扰素的均匀性。