公开(公告)号：US07834314B2

公开(公告)日：2010-11-16

申请号：US12082149

申请日：2008-04-08

申请人： Peter Wagner ,  Mark A. Scalf ,  Frank Zaugg

发明人： Peter Wagner ,  Mark A. Scalf ,  Frank Zaugg

IPC分类号： H01J49/00 ,  C02F1/40 ,  B01L3/00

CPC分类号： H01J49/0418 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/069 ,  B01L2300/0819 ,  Y10T436/11 ,  Y10T436/114165 ,  Y10T436/143333

摘要： Methods and assemblies for ion detection in samples using a chip with elevated sample zones, also known as a “pillar chip.” Methods include analyzing such a sample by desorbing a sample from a chip, producing a described ion sample and detecting the same. The chip comprises a base having a surface and one or more structures protruding above the surface of the base. Each structure comprises a pillar and a sample zone, the latter containing a support material and the sample to be analyzed. Assemblies include a chip such as that described above and a conductive element that comprises an aperture of sufficient proportion to allow passage of a molecular ion and that is adapted to be at a different electrical potential than the base of the chip.

摘要翻译： 使用具有升高的样品区的芯片的样品中的离子检测方法和组件，也称为“柱芯片”。方法包括通过从芯片解吸样品来分析这样的样品，产生所述离子样品并进行检测。 芯片包括具有突出在基底表面上方的表面和一个或多个结构的基底。 每个结构包括柱和样品区，后者包含支撑材料和要分析的样品。 组件包括如上所述的芯片和包括足够比例的孔以允许分子离子通过并且适于处于与芯片的基极不同的电位的导电元件。

公开(公告)号：US20100178518A1

公开(公告)日：2010-07-15

申请号：US12301316

申请日：2008-05-29

申请人： Peter Wagner

发明人： Peter Wagner

IPC分类号： B32B9/04 ,  B23H1/00

CPC分类号： B23H9/00 ,  B23H1/00 ,  B23H7/02 ,  B23H9/02 ,  F01C1/086 ,  F01C1/165 ,  F04C2230/101 ,  F04C2230/41 ,  F04C2230/91

摘要： Method for manufacturing a machine housing having a fluid chamber (14) with a hardening layer (16) on an internal wall surface, in which the hardening layer (16) is made of a material, that, per-se, is not electrically conductive but has been made conductive by additives, and in that the surface of the hardening layer (16) is machined by electro-discharge machining.

摘要翻译： 一种用于制造具有在内壁表面上具有硬化层（16）的流体室（14）的机械壳体的方法，其中所述硬化层（16）由材料制成，其本身不导电 但是已经通过添加剂导电，并且通过放电加工来加工硬化层（16）的表面。

公开(公告)号：US07753372B2

公开(公告)日：2010-07-13

申请号：US11372046

申请日：2006-03-10

申请人： Peter Wagner ,  Christoph Sägesser

发明人： Peter Wagner ,  Christoph Sägesser

IPC分类号： B65H5/12

CPC分类号： B65H5/30 ,  B65H2301/4531

摘要： An apparatus for opening and depositing a signature onto a transporting device includes a continuously rotating gripper cylinder having a first shaft and carrying at least one signature. First and second opening cylinders are arranged below the gripper cylinder to open the signature and deposit the opened signature onto the transporting device. The first and second opening cylinders each have a second and third shafts, respectively, extending substantially parallel to the first shaft. The first and second opening cylinders each have a peripheral section, the peripheral section of the first opening cylinder engaging in a region of rotation of the gripper cylinder to grip a signature such that the signature can be released again. The first opening cylinder includes a guide element to aid in conveying the signature.

摘要翻译： 用于将签名打开和沉积到传送装置上的装置包括具有第一轴并且承载至少一个签名的连续旋转的夹持器筒。 第一和第二打开气缸布置在夹持器气缸下方以打开签名并将打开的签名存储在传送装置上。 第一和第二开口圆筒各自具有基本上平行于第一轴延伸的第二和第三轴。 第一和第二开口圆筒各自具有周边部分，第一开口圆筒的周边部分接合夹持器圆筒的旋转区域以夹持签名，从而可以再次释放签名。 第一打开圆柱体包括一个辅助传送签名的引导元件。

公开(公告)号：US20100086608A1

公开(公告)日：2010-04-08

申请号：US12593616

申请日：2008-04-04

申请人： Mark Mitchnick ,  Andrew Loxley ,  David Fairhurst ,  Peter Wagner

发明人： Mark Mitchnick ,  Andrew Loxley ,  David Fairhurst ,  Peter Wagner

IPC分类号： A61K9/14 ,  G01N33/566 ,  G01N30/96 ,  A61K38/00 ,  A61K31/7088 ,  A61K31/70 ,  A61K38/16

CPC分类号： G01N33/54373 ,  G01N33/542 ,  G01N33/54313

摘要： Methods, devices and arrays for measuring a change in zeta-potential of a surface indicative of a binding event are provided. Pharmacologically active compounds and delivery systems for active pharmaceutical ingredients determined to be pharmacologically active or optimized for pharmacological activity or determined to be useful for delivery of the active pharmaceutical ingredient to a target via measurement of a change in zeta-potential of the compound, ingredient or delivery system are also provided.

摘要翻译： 提供了用于测量指示结合事件的表面的ζ电位变化的方法，装置和阵列。 活性药物成分的药理学活性化合物和递送系统被确定为药理学活性或针对药理学活性而优化，或被确定为可用于通过测量化合物，成分或成分的ζ-电位变化将活性药物成分递送至靶标 还提供送货系统。

公开(公告)号：US07565452B2

公开(公告)日：2009-07-21

申请号：US11051408

申请日：2005-02-04

申请人： Volker Freiburg ,  Gerd Spalink ,  Peter Wagner

发明人： Volker Freiburg ,  Gerd Spalink ,  Peter Wagner

IPC分类号： G06F15/16 ,  G06F12/00

CPC分类号： G11B27/105 ,  G11B20/10

摘要： A system for storing and rendering multimedia data includes a first storage configured to store multimedia data files of a plurality of formats. The system also includes a second storage configured to store program files including information regarding a transformation of multimedia data files of a first format into multimedia data files of a second format, where the first format is one of the plurality of formats. The system also includes a rendering device configured to render multimedia data files of the second format. At least one of the multimedia data files stored in the first storage is linked to at least one of the program files, and the program file includes information regarding a transformation of multimedia data files of the format of the at least one of the multimedia data files into the second format.

摘要翻译： 用于存储和呈现多媒体数据的系统包括被配置为存储多种格式的多媒体数据文件的第一存储器。 该系统还包括第二存储器，其被配置为存储包括关于将第一格式的多媒体数据文件转换成第二格式的多媒体数据文件的信息的程序文件，其中第一格式是多种格式之一。 该系统还包括被配置为呈现第二格式的多媒体数据文件的呈现装置。 存储在第一存储器中的至少一个多媒体数据文件被链接到至少一个程序文件，并且程序文件包括关于多媒体数据文件的格式的多媒体数据文件的转换的信息 进入第二种格式。

公开(公告)号：US20090148869A1

公开(公告)日：2009-06-11

申请号：US12329380

申请日：2008-12-05

申请人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

发明人： Frank Zaugg ,  Renee Tobias ,  Silvia McManus ,  Peter Kernen ,  Laurence Ruiz-Taylor ,  Peter Wagner

IPC分类号： G01N33/53 ,  C12Q1/06 ,  G01N33/569 ,  C12M1/00

CPC分类号： G01N33/54326 ,  G01N33/491 ,  G01N33/538 ,  G01N33/54313 ,  G01N33/56972

摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

摘要翻译： 公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。 该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够 特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。 在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域 收集室。 与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

公开(公告)号：US20090092479A1

公开(公告)日：2009-04-09

申请号：US11720628

申请日：2005-11-11

申请人： Peter Wagner

发明人： Peter Wagner

IPC分类号： F01D5/12

CPC分类号： F04D29/2288 ,  F04D7/045 ,  F04D29/181

摘要： A pump having an axial impeller (40) with helical blades (38) for sucking liquid through an intake opening (38) formed at a bottom side of the axial impeller (40), in which the blades (38) are provided, at the bottom side of the axial impeller (40), with a first cutting edge (58) which, when the axial impeller (40) rotates, are in cutting relation with at least one second cutting edge (60) formed at the intake opening (36).

摘要翻译： 一种具有轴向叶轮（40）的泵，其具有螺旋叶片（38），用于通过形成在所述轴向叶轮（40）的底侧处的入口（38）来吸入液体，所述入口开口（38）设置在所述轴向叶轮 具有第一切削刃（58），当所述轴向叶轮（40）旋转时，所述第一切削刃与形成在所述进气口（36）处的至少一个第二切削刃（60）处于切割关系 ）。

公开(公告)号：US20080203291A1

公开(公告)日：2008-08-28

申请号：US12082149

申请日：2008-04-08

申请人： Peter Wagner ,  Mark A. Scalf ,  Frank Zaugg

发明人： Peter Wagner ,  Mark A. Scalf ,  Frank Zaugg

IPC分类号： B01D59/44

CPC分类号： H01J49/0418 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/069 ,  B01L2300/0819 ,  Y10T436/11 ,  Y10T436/114165 ,  Y10T436/143333

摘要： Methods and assemblies for ion detection in samples using a chip with elevated sample zones, also known as a “pillar chip.” Methods include analyzing such a sample by desorbing a sample from a chip, producing a described ion sample and detecting the same. The chip comprises a base having a surface and one or more structures protruding above the surface of the base. Each structure comprises a pillar and a sample zone, the latter containing a support material and the sample to be analyzed. Assemblies include a chip such as that described above and a conductive element that comprises an aperture of sufficient proportion to allow passage of a molecular ion and that is adapted to be at a different electrical potential than the base of the chip.

摘要翻译： 使用具有升高样品区的芯片的样品中的离子检测方法和组件，也称为“柱芯片”。 方法包括通过从芯片解吸样品来分析这样的样品，产生所述的离子样品并进行检测。 芯片包括具有突出在基底表面上方的表面和一个或多个结构的基底。 每个结构包括柱和样品区，后者包含支撑材料和要分析的样品。 组件包括如上所述的芯片和包括足够比例的孔以允许分子离子通过并且适于处于与芯片的基极不同的电位的导电元件。

公开(公告)号：US20080152481A1

公开(公告)日：2008-06-26

申请号：US11816630

申请日：2006-02-16

申请人： Peter Wagner

发明人： Peter Wagner

IPC分类号： F01D5/12

CPC分类号： F04D7/045 ,  F04D29/2288

摘要： Pump having a cutting impeller (38), counter knives (40) associated therewith, and a pre-chopper (48) which is driven by a shaft portion (46) that projects axially from the cutting impeller (38), characterised in that the counter knives (40) carry a cutting edge (52) that extends in longitudinal direction of the shaft portion (46).

摘要翻译： 具有切割叶轮（38）的泵，与其相关联的相对刀（40）和由从切割叶轮（38）轴向突出的轴部分（46）驱动的预切割器（48），其特征在于， 副刀具（40）具有沿轴部（46）的纵向方向延伸的切削刃（52）。

公开(公告)号：USD569635S1

公开(公告)日：2008-05-27

申请号：US29278946

申请日：2007-04-16

申请人： Peter Wagner

设计人： Peter Wagner