公开(公告)号：US10077287B2

公开(公告)日：2018-09-18

申请号：US14833422

申请日：2015-08-24

Applicant: Bristol-Myers Squibb Company

Inventor： Heidi L. Perez ,  Donna Wei ,  Robert M. Borzilleri ,  Sanjeev Gangwar ,  Gretchen M. Schroeder ,  Heng Cheng ,  Robert J. Schmidt

IPC: A61K47/65 ,  A61K38/07 ,  C07K5/10 ,  C07K5/078 ,  C07K5/062 ,  A61K47/48 ,  C07K16/30

CPC classification number: C07K5/06139 ,  A61K47/6803 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6889 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06052 ,  C07K16/3038 ,  C07K16/3046

Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

公开(公告)号：US09822144B2

公开(公告)日：2017-11-21

申请号：US15587715

申请日：2017-05-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong Zhang ,  Ivar M. McDonald ,  Naidu S. Chowdari ,  Tram N. Huynh ,  Robert M. Borzilleri ,  Sanjeev Gangwar

IPC: C07D487/04 ,  C07D519/00 ,  C07K5/062

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

公开(公告)号：US08980824B2

公开(公告)日：2015-03-17

申请号：US14177376

申请日：2014-02-11

Applicant: Bristol-Myers Squibb Company

Inventor： Qiang Cong ,  Heng Cheng ,  Sanjeev Gangwar

IPC: A61K38/00 ,  A61K39/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K5/117 ,  A61K47/48 ,  C07K7/06 ,  C07K5/06 ,  C07K5/078

CPC classification number: C07K5/1024 ,  A61K38/05 ,  A61K38/07 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48607 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6863 ,  A61K47/6869 ,  C07K5/06 ,  C07K5/06139 ,  C07K5/06165 ,  C07K5/10 ,  C07K5/1016 ,  C07K7/06

Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Abstract translation: 其中R 1，R 2，R 3a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调节素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与 靶向部分。

公开(公告)号：US20130209494A1

公开(公告)日：2013-08-15

申请号：US13764226

申请日：2013-02-11

Applicant: Bristol-Myers Squibb Company

Inventor： Naidu S. CHOWDARI ,  Sanjeev Gangwar ,  Bilal Sufi

IPC: C07K16/18 ,  C07D491/08

CPC classification number: C07D491/08 ,  A61K31/439 ,  A61K47/48384 ,  A61K47/6803 ,  C07K16/18

Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.

Abstract translation: 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。