公开(公告)号：US09290761B2

公开(公告)日：2016-03-22

申请号：US14138472

申请日：2013-12-23

Applicant: California Institute of Technology

Inventor： David Baltimore ,  Ryan M. O'Connell ,  Konstantin Taganov ,  Mark Boldin

IPC: A01N43/04 ,  C12Q1/68 ,  C12N15/113 ,  A61K31/56 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/31

Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arntl, Picalm, Jarid2, PU.1, Csflr, HIF1α, Sla, Cepbβ, and Bach1, and the like.

Abstract translation: 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断治疗疾病（包括炎症和骨髓增生）的方法和组合物，调节选自Cut1，Arnt1，Picalm，Jarid2，PU.1，Csflr，HIF1α，Sla的一种或多种基因的表达水平 ，Cepb＆bgr，和Bach1等。

公开(公告)号：US20150175667A1

公开(公告)日：2015-06-25

申请号：US14532371

申请日：2014-11-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Pin Wang ,  Lili Yang ,  David Baltimore

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/21

CPC classification number: C12N15/86 ,  A61K31/70 ,  A61K35/76 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/178 ,  A61K38/1793 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/204 ,  A61K38/2046 ,  A61K38/2086 ,  A61K39/21 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2810/609 ,  C12N2810/855 ,  Y02A50/386 ,  Y02A50/396 ,  Y02A50/401 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/466 ,  Y02A50/475 ,  Y02A50/48 ,  Y02A50/481 ,  Y02A50/492 ,  A61K2300/00

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract translation: 提供了将编码感兴趣的基因（通常为抗原）的多核苷酸递送至树突状细胞（DC）的方法和组合物。 病毒包膜包含DC-SIGN特异性靶向分子。 方法和相关组合物可用于治疗患有广泛病症的患者，包括感染，例如HIV / AIDS和各种类型的癌症。

公开(公告)号：US20140212876A1

公开(公告)日：2014-07-31

申请号：US14166681

申请日：2014-01-28

Applicant: California Institute of Technology

Inventor： Parameswaran Ramakrishnan ,  David Baltimore

IPC: G01N33/50

CPC classification number: G01N33/5023 ,  A61K31/513 ,  A61K31/655 ,  A61K31/7028 ,  G01N2440/38

Abstract: Serine 350 has been identified as the site of O-GlycNAcylation of c-Rel. Methods are provided for identifying compositions capable of blocking c-Rel activation. The methods generally involve identifying compounds that inhibit O-GlcNAcylation of c-Rel at the serine 350 residue, thereby preventing c-Rel activation and production of c-Rel-dependent cytokines.

Abstract translation: 丝氨酸350已经被鉴定为c-Rel的O-糖基化的位点。 提供了用于鉴定能够阻断c-Rel活化的组合物的方法。 所述方法通常涉及鉴定在丝氨酸350残基处抑制c-Rel的O-GlcNAc化的化合物，从而防止c-Rel活化并产生c-Rel依赖性细胞因子。

公开(公告)号：US20130260453A1

公开(公告)日：2013-10-03

申请号：US13750903

申请日：2013-01-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Carlos Lois-Caballe ,  David Baltimore ,  Xiao-Feng Qin

IPC: C12N15/867 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C12N7/00 ,  C12N15/113 ,  C12N15/1132 ,  C12N15/1138 ,  C12N15/867 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2310/531 ,  C12N2330/30 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2830/003 ,  C12N2830/006 ,  C12N2830/008 ,  C12N2830/30 ,  C12N2830/48 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  C12Q1/6897 ,  Y02A50/465

Abstract: The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.