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公开(公告)号：US10537426B2
公开(公告)日：2020-01-21
申请号：US15668559
申请日：2017-08-03
Applicant: CARDIOVALVE LTD.
Inventor： Meni Iamberger , Aviram Baum , Boaz Harari , Ilia Hariton
Abstract: A tubular valve body has an upstream end and a downstream end, and has a central longitudinal axis, and defines a lumen along the axis. Prosthetic leaflets are disposed within the lumen, and are configured to facilitate one-way movement of fluid through the lumen in an upstream-to-downstream direction. The valve body has a cellular structure defined by a plurality of joists connected at nodes, the joists and nodes delimiting cells of the cellular structure. The nodes include minor nodes at which 2-4 joists are connected, and major nodes at which 6-8 joists are connected. The cells of the cellular structure comprise a first circumferential row of first-row cells. Each of the first-row cells is connected to each of its circumferentially-adjacent first-row cells at a respective one of the major nodes, and is longitudinally delimited by two of the minor nodes. Other embodiments are described.
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公开(公告)号：US10507105B2
公开(公告)日：2019-12-17
申请号：US16008618
申请日：2018-06-14
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, a prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body having an atrial end, a ventricular end, and an intermediate portion between the atrial end and the ventricular end. Atrial anchoring arms and ventricular anchoring legs may extend from the intermediate portion of the valve body. At least one atrial anchoring arm may extend radially outward beyond a terminal end of at least one ventricular anchoring leg. The atrial arms and the ventricular legs may be devoid of lateral interconnections therebetween beyond locations of connection to the intermediate portion. At least one atrial anchoring arm may extend in the generally radially outward direction from a single location of connection to the intermediate portion of the valve body.
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公开(公告)号：US10449047B2
公开(公告)日：2019-10-22
申请号：US15682789
申请日：2017-08-22
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: A tubular portion of a valve frame circumscribes a longitudinal axis, and defines a lumen along the axis and a plurality of valve-frame coupling elements disposed circumferentially around the axis. An outer frame: (a) comprises a ring defined by a pattern of alternating peaks and troughs, the pattern having an amplitude, (b) comprises a plurality of legs, coupled to the ring at respective troughs, and (c) is shaped to define a plurality of outer-frame coupling elements, each coupled to the ring, and fixed with respect to a respective valve-frame coupling element. Compression of the tubular portion from an expanded state toward a compressed state reduces a circumferential distance between each of the outer-frame coupling elements and its adjacent outer-frame coupling elements, and increases the amplitude of the pattern of the ring.
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公开(公告)号：US12220313B2
公开(公告)日：2025-02-11
申请号：US18109937
申请日：2023-02-15
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Meni Iamberger , Aviram Baum , Boaz Harari
IPC: A61F2/24
Abstract: An expandable prosthetic valve is implantable within a native mitral valve by terminal ends of ventricular anchors of the prosthetic valve moving outwardly from a constrained delivery position of the ventricular anchors, while the ventricular anchors are positioned within the atrium. Then, a portion of the expandable prosthetic valve containing the ventricular anchors is advanced through the native mitral valve into the ventricle. Terminal ends of atrial anchors of the prosthetic valve move outwardly relative to a portion of an annular valve body of the prosthetic valve while the atrial anchors are at least partially positioned within the atrium. Next, the annular valve body is radially expanded while the ventricular anchors are in the ventricle and the atrial anchors are in the atrium, thereby anchoring native heart valve tissue between the atrial anchors and ventricular anchors. Other embodiments are also described.
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公开(公告)号：US12064347B2
公开(公告)日：2024-08-20
申请号：US18090058
申请日：2022-12-28
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Meni Iamberger , Boaz Harari , Aviram Baum
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/24 , A61F2/2427 , A61F2/2436 , A61F2210/0014 , A61F2220/0008 , A61F2220/0075 , A61F2250/0003 , A61F2250/0039
Abstract: A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts arranged in a cellular structure defined by first and second circumferential rows of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. The struts are joined at four corners of the four-side closed cell. Each of the four sides of each of the four-sided closed cells is double-strutted. Other embodiments are also described.
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Patent Agency Ranking
公开(公告)号：US11672658B2
公开(公告)日：2023-06-13
申请号：US16907615
申请日：2020-06-22
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
CPC classification number: A61F2/2436 , A61F2/243 , A61F2/2409 , A61F2/2418 , A61F2/9517 , A61F2002/91575 , A61F2220/0016 , A61F2220/0025
Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve configured to transition between radially compressed and radially expanded configurations may be provided. The prosthetic heart valve may include an outer frame, an inner frame, and at least one tissue anchor extending from at least one of the frames. The prosthetic heart valve may be configured to maintain a first distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially compressed configuration and a second distance between the downstream ends of the inner and outer frames when the prosthetic heart valve is in the radially expanded configuration, the first distance being greater than the second distance.
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公开(公告)号：US11571298B2
公开(公告)日：2023-02-07
申请号：US17101787
申请日：2020-11-23
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Meni Iamberger , Yelena Kasimov , Boaz Harari , Aviram Baum
IPC: A61F2/24
Abstract: An implant includes a prosthetic valve and is transitionable from a compressed to an expanded state. The implant includes a frame assembly including a plurality of struts that collectively define an upstream-frame-assembly-perimeter at an upstream end of the frame assembly and a downstream-frame-assembly-perimeter at a downstream end of the frame assembly. The frame assembly includes a valve frame that defines a lumen, and one or more appendages disposed at and extending in a downstream direction from the downstream-frame-assembly-perimeter. A plurality of prosthetic leaflets are disposed within the valve frame lumen and facilitate one-way upstream-to-downstream fluid flow through the lumen. The implant includes a fabric and, in the expanded state of the implant, the fabric obscures the one or more appendages and defines a downstream perimeter of the fabric at a downstream end of the implant. Additional embodiments are described.
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公开(公告)号：US11534298B2
公开(公告)日：2022-12-27
申请号：US16879952
申请日：2020-05-21
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari
Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve may include an annular outer frame, an inner frame, and a plurality of ventricular anchoring legs extending from the outer frame. The outer frame may be formed at least partially of struts intersecting at junctions. At least one ventricular anchoring leg may include a first curved leg portion on a first surface of the leg, and a second curved leg portion on a second, opposite surface of the leg. The outer frame may also include a strut extending between a downstream end of the outer frame and the junction from which the at least one ventricular anchoring leg extends.
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公开(公告)号：US20210307906A1
公开(公告)日：2021-10-07
申请号：US17353063
申请日：2021-06-21
Applicant: Cardiovalve Ltd.
Inventor： Boaz Harari , Ilia Hariton
Abstract: Apparatus (20) for testing a prosthetic leaflet (10) includes a bar (22); a light source (24); a detector (26); an actuator (40); a gauge (28); a display (82); and circuitry (84). The leaflet is draped over the bar. The light source emits a beam of light (32). The detector detects the beam, and generates a detection-signal indicative of detection of the beam. Actuation of the actuator moves the bar with respect to the beam. The gauge measures an elevation of the bar above the beam, the elevation changing with the moving of the bar by the actuator. The circuitry is configured: (i) to receive the measured elevation from the gauge, (ii) to receive the detection-signal from the detector, and (iii) in response to the detection-signal, to drive the display to display the elevation that was measured when the detection-signal was received by the circuitry.
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公开(公告)号：US20210093449A1
公开(公告)日：2021-04-01
申请号：US17101787
申请日：2020-11-23
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Meni Iamberger , Yelena Kasimov , Boaz Harari , Aviram Baum
IPC: A61F2/24
Abstract: An implant includes a prosthetic valve and is transitionable from a compressed to an expanded state. The implant includes a frame assembly including a plurality of struts that collectively define an upstream-frame-assembly-perimeter at an upstream end of the frame assembly and a downstream-frame-assembly-perimeter at a downstream end of the frame assembly. The frame assembly includes a valve frame that defines a lumen, and one or more appendages disposed at and extending in a downstream direction from the downstream-frame-assembly-perimeter. A plurality of prosthetic leaflets are disposed within the valve frame lumen and facilitate one-way upstream-to-downstream fluid flow through the lumen. The implant includes a fabric and, in the expanded state of the implant, the fabric obscures the one or more appendages and defines a downstream perimeter of the fabric at a downstream end of the implant. Additional embodiments are described.
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