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公开(公告)号：US09763924B2
公开(公告)日：2017-09-19
申请号：US14723964
申请日：2015-05-28
发明人： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： C07D453/02 , A61K31/44 , A61K31/444 , C07D409/12 , A61K31/4545 , A61K31/4436 , C07D409/14
CPC分类号： A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
摘要： Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US09597323B2
公开(公告)日：2017-03-21
申请号：US15168438
申请日：2016-05-31
发明人： Gabriele Amari , Elisabetta Armani , Herve Van De Poeol , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/444 , C07D401/12 , A61K31/452 , C07D453/02
CPC分类号： A61K31/444 , A61K31/452 , C07D401/12 , C07D453/02
摘要： Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
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公开(公告)号：US09527846B2
公开(公告)日：2016-12-27
申请号：US15131401
申请日：2016-04-18
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D498/02 , A61K31/553 , C07D471/04 , C07D401/12 , C07D403/12 , C07D519/00 , C07D487/08 , C07D498/08 , C07C53/06 , C07D231/40
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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公开(公告)号：US20160346268A1
公开(公告)日：2016-12-01
申请号：US15168425
申请日：2016-05-31
发明人： Gabriele AMARI , Elisabetta Armani , Wesley Blackaby , Herve Van De Poeol , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/4545 , C07D453/02 , A61K31/444 , A61K31/46 , A61K31/4436 , A61K31/496 , C07D451/02 , C07D409/14 , A61K31/4439
CPC分类号： A61K31/4545 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , C07D409/14 , C07D451/02 , C07D453/02
摘要： Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratrory tract.
摘要翻译： 本文定义的式（I）化合物均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于治疗呼吸道疾病。
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公开(公告)号：US09487528B2
公开(公告)日：2016-11-08
申请号：US14731786
申请日：2015-06-05
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K9/0075 , A61K9/008 , A61K31/519
摘要： Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.
摘要翻译： 本文所述的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。
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公开(公告)号：US09315503B2
公开(公告)日：2016-04-19
申请号：US14819722
申请日：2015-08-06
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D498/02 , A61K31/553 , C07D471/04
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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57.发明授权Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors 有权1-苯基-2-吡啶基烷基醇的衍生物作为磷酸二酯酶抑制剂公开(公告)号：US09265768B2
公开(公告)日：2016-02-23
申请号：US14164527
申请日：2014-01-27
IPC分类号： C07D211/82 , A61K31/435 , A61K31/5377 , C07D213/89 , C07D213/69 , A61K31/44 , A61K31/4439 , A61K31/496 , A61M15/00 , A61M16/14 , C07D213/55 , C07D213/56 , C07D401/12 , C07D413/12 , C07D417/12
CPC分类号： A61K31/5377 , A61K31/44 , A61K31/4439 , A61K31/496 , A61M15/0045 , A61M15/009 , A61M16/14 , C07D213/55 , C07D213/56 , C07D213/69 , C07D213/89 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
摘要翻译： 本发明涉及磷酸二酯酶4（PDE4）酶的抑制剂。 更具体地，本发明涉及作为1-苯基-2-吡啶基烷基醇的衍生物的化合物，制备这些化合物的方法，含有它们的组合物及其治疗用途。
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公开(公告)号：US09145413B2
公开(公告)日：2015-09-29
申请号：US14330145
申请日：2014-07-14
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D498/02 , C07D471/04 , C07D401/12 , C07D403/12 , C07D519/00 , C07D487/08 , C07D498/08 , C07C53/06
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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公开(公告)号：US09145409B2
公开(公告)日：2015-09-29
申请号：US14560009
申请日：2014-12-04
发明人： Gabriele Amari , Elisabetta Armani , Carmelida Capaldi , Renato De Fanti , Mauro Riccaboni , Charles Baker-Glenn , Hervé Van De Poël
IPC分类号： C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496
CPC分类号： C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds having a benzhydryl structure represented by formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
摘要翻译： 具有本文所述的式（I）表示的二苯甲基结构的化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于治疗呼吸道疾病。
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公开(公告)号：US08907094B2
公开(公告)日：2014-12-09
申请号：US13708324
申请日：2012-12-07
发明人： Monique Bodil Van Niel , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： A61K31/553 , C07D471/02 , C07D401/12 , C07D471/04 , C07D403/12 , C07D519/00
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译： 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病
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