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公开(公告)号：US09199980B2
公开(公告)日：2015-12-01
申请号：US14097586
申请日：2013-12-05
发明人： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve′ Van de Poel , Ben Whittaker
IPC分类号： A61K31/44 , A61K9/14 , C07D453/02 , C07D421/00 , C07D401/14 , C07D401/12 , C07D453/00 , A61K31/439 , A61K9/00
CPC分类号： C07D453/02 , A61K9/0075 , A61K31/439 , C07D401/12 , C07D401/14 , C07D453/00
摘要： Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
摘要翻译： 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US10087176B2
公开(公告)日：2018-10-02
申请号：US15316401
申请日：2014-06-04
发明人： Gabriele Amari , Elisabetta Armani , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve Van De Poel , Ben Whittaker
IPC分类号： C07D453/02
摘要： The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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公开(公告)号：US09636336B2
公开(公告)日：2017-05-02
申请号：US15168425
申请日：2016-05-31
发明人： Gabriele Amari , Elisabetta Armani , Wesley Blackaby , Herve Van De Poeol , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/4545 , C07D409/14 , C07D453/02 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/496 , C07D451/02 , A61K31/46
CPC分类号： A61K31/4545 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , C07D409/14 , C07D451/02 , C07D453/02
摘要： Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
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公开(公告)号：US20180016265A1
公开(公告)日：2018-01-18
申请号：US15718707
申请日：2017-09-28
发明人： Elisabetta ARMANI , Gabriele Amari , Wesley Blackaby , Herve Van De Poel , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： C07D409/12 , C07D453/02 , A61K31/4545 , A61K31/439 , A61K31/4439 , A61K31/4436 , C07D471/08 , C07D409/14
CPC分类号： C07D409/12 , A61K31/439 , A61K31/4436 , A61K31/4439 , A61K31/4545 , C07D409/14 , C07D453/02 , C07D471/08
摘要： Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
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公开(公告)号：US10117860B2
公开(公告)日：2018-11-06
申请号：US15673710
申请日：2017-08-10
发明人： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/444 , A61K31/4545 , A61K31/4436 , C07D453/02 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US20170340616A1
公开(公告)日：2017-11-30
申请号：US15673710
申请日：2017-08-10
发明人： Elisabetta Armani , Gabriele Gabriele , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/444 , C07D409/12 , A61K31/4436 , A61K31/4545 , C07D453/02 , C07D409/14
CPC分类号： A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
摘要： Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US09809582B2
公开(公告)日：2017-11-07
申请号：US15148225
申请日：2016-05-06
发明人： Elisabetta Armani , Gabriele Amari , Wesley Blackaby , Herve Van De Poel , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/4545 , C07D409/12 , C07D409/14 , C07D471/08 , A61K31/439 , A61K31/4436 , A61K31/4439 , C07D453/02
CPC分类号： C07D409/12 , A61K31/439 , A61K31/4436 , A61K31/4439 , A61K31/4545 , C07D409/14 , C07D453/02 , C07D471/08
摘要： Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
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公开(公告)号：US09763924B2
公开(公告)日：2017-09-19
申请号：US14723964
申请日：2015-05-28
发明人： Elisabetta Armani , Gabriele Amari , Carmelida Capaldi , Wesley Blackaby , Ian Linney , Hervé Van De Poël , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： C07D453/02 , A61K31/44 , A61K31/444 , C07D409/12 , A61K31/4545 , A61K31/4436 , C07D409/14
CPC分类号： A61K31/444 , A61K31/4436 , A61K31/4545 , C07D409/12 , C07D409/14 , C07D453/02
摘要： Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
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公开(公告)号：US20160346268A1
公开(公告)日：2016-12-01
申请号：US15168425
申请日：2016-05-31
发明人： Gabriele AMARI , Elisabetta Armani , Wesley Blackaby , Herve Van De Poeol , Charles Baker-Glenn , Naimisha Trivedi
IPC分类号： A61K31/4545 , C07D453/02 , A61K31/444 , A61K31/46 , A61K31/4436 , A61K31/496 , C07D451/02 , C07D409/14 , A61K31/4439
CPC分类号： A61K31/4545 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/46 , A61K31/496 , C07D409/14 , C07D451/02 , C07D453/02
摘要： Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratrory tract.
摘要翻译： 本文定义的式（I）化合物均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于治疗呼吸道疾病。
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公开(公告)号：US20140155427A1
公开(公告)日：2014-06-05
申请号：US14097586
申请日：2013-12-05
发明人： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve' Van de Poel , Ben Whittaker
IPC分类号： C07D453/02 , A61K31/444
CPC分类号： C07D453/02 , A61K9/0075 , A61K31/439 , C07D401/12 , C07D401/14 , C07D453/00
摘要： Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
摘要翻译： 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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