公开(公告)号：US20250120666A1

公开(公告)日：2025-04-17

申请号：US18940602

申请日：2024-11-07

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: A61B6/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12245882B2

公开(公告)日：2025-03-11

申请号：US18612980

申请日：2024-03-21

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/04 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12178627B2

公开(公告)日：2024-12-31

申请号：US18641232

申请日：2024-04-19

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06V10/74 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/764 ,  G06V10/82

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12156759B2

公开(公告)日：2024-12-03

申请号：US18629673

申请日：2024-04-08

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06V10/74 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/764 ,  G06V10/82

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12141976B2

公开(公告)日：2024-11-12

申请号：US18586145

申请日：2024-02-23

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12097063B2

公开(公告)日：2024-09-24

申请号：US18525434

申请日：2023-11-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: G06V10/74 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/764 ,  G06V10/82

CPC classification number: A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240307016A1

公开(公告)日：2024-09-19

申请号：US18670506

申请日：2024-05-21

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: A61B6/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82

CPC classification number: A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240260913A1

公开(公告)日：2024-08-08

申请号：US18612980

申请日：2024-03-21

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

CPC classification number: A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US11967078B2

公开(公告)日：2024-04-23

申请号：US18148995

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10

CPC classification number: G06T7/0012 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20230289963A1

公开(公告)日：2023-09-14

申请号：US18179921

申请日：2023-03-07

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G06T7/00 ,  G06T7/62 ,  A61B5/00

CPC classification number: G06T7/0012 ,  G06T7/62 ,  A61B5/7275 ,  G06T2207/30101 ,  G06T2207/20081 ,  G06T2207/10081 ,  G06T2207/10108 ,  G06T2207/10104 ,  G06T2207/10101 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/10048

Abstract: Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.