公开(公告)号：US20090317357A1

公开(公告)日：2009-12-24

申请号：US10546569

申请日：2004-02-24

申请人： Lawrence Steinman ,  Rosetta Pedotti

发明人： Lawrence Steinman ,  Rosetta Pedotti

IPC分类号： A61K38/20 ,  A61K39/00 ,  A61K31/7088 ,  A61K31/132

CPC分类号： A61K31/13

摘要： Methods for treating or preventing an autoimmune disease using agents that block the histamine H1 receptor are disclosed. H1 receptor-blocking agents useful in accordance with the methods provided herein include, for example, H1 antihistamines, particularly H1 antihistamines that do not substantially block the serotonin receptor.

摘要翻译： 公开了使用阻断组胺H1受体的药物治疗或预防自身免疫疾病的方法。 根据本文提供的方法有用的H1受体阻断剂包括例如H1抗组胺剂，特别是基本上不阻断5-羟色胺受体的H1抗组胺药。

公开(公告)号：US20090281170A1

公开(公告)日：2009-11-12

申请号：US12467857

申请日：2009-05-18

申请人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

发明人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

IPC分类号： A61K31/711

CPC分类号： A61K39/001 ,  A61K38/2026 ,  A61K39/0007 ,  A61K39/0008 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55561 ,  C07K2319/30

摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.

公开(公告)号：US07544669B2

公开(公告)日：2009-06-09

申请号：US10302098

申请日：2002-11-21

申请人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

发明人： Paulo Fontoura ,  Hideki Garren ,  William H. Robinson ,  Lawrence Steinman ,  Pedro Jose Ruiz ,  Paul J. Utz

IPC分类号： A61K31/70 ,  C12N5/00 ,  C12N15/00 ,  A61K48/00

CPC分类号： A61K39/001 ,  A61K38/2026 ,  A61K39/0007 ,  A61K39/0008 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55561 ,  C07K2319/30

摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.

摘要翻译： 本发明提供了一种治疗或预​​防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法， 所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。 施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答 （s）表示自我向量的管理。 本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病 其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。

公开(公告)号：US07282490B2

公开(公告)日：2007-10-16

申请号：US10495893

申请日：2002-11-21

申请人： Dorothee Chabas ,  Lawrence Steinman

发明人： Dorothee Chabas ,  Lawrence Steinman

IPC分类号： A61K31/70 ,  A01N43/04 ,  C12P21/06 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02

CPC分类号： C07K14/52 ,  A61K48/00

摘要： This invention provides a method for reducing the amount of osteopontin in an osteopontin-expressing cell comprising introducing into the cell a nucleic acid which specifically inhibits osteopontin expression in the cell. This invention also provides methods for inhibiting the onset of, and treating, osteopontin-related disorders, as well as compositions for practicing the same. This invention further provides methods for determining the amount of osteopontin in a sample, and a kit for practicing the same. This invention also provides methods for determining whether an agent reduces the amount of osteopontin in an osteopontin-expressing cell. Finally, this invention provides methods for treating a subject afflicted with a disorder mediated by an endogenous protein.

摘要翻译： 本发明提供减少骨桥蛋白表达细胞中骨桥蛋白含量的方法，包括向细胞内引入特异性抑制细胞中骨桥蛋白表达的核酸。 本发明还提供了抑制骨桥蛋白相关疾病的发生和治疗以及用于实践它们的组合物的方法。 本发明还提供了用于测定样品中骨桥蛋白含量的方法，以及用于实施其的试剂盒。 本发明还提供了用于确定试剂是否降低骨桥蛋白表达细胞中骨桥蛋白含量的方法。 最后，本发明提供了治疗受内源性蛋白质介导的病症折磨的受试者的方法。

公开(公告)号：US06489299B2

公开(公告)日：2002-12-03

申请号：US09989476

申请日：2001-11-19

申请人： Lawrence Steinman ,  Nicholas Ling ,  Paul J. Conlon ,  Amitabh Gaur

发明人： Lawrence Steinman ,  Nicholas Ling ,  Paul J. Conlon ,  Amitabh Gaur

IPC分类号： A61K3810

CPC分类号： C07K14/4713 ,  A61K38/00

摘要： Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.

摘要翻译： 提供了含有髓鞘碱性蛋白质残基87-99的肽类似物。 肽类似物的残基91从天然蛋白质中发现的L-赖氨酸残基改变为任何其它氨基酸。 提供肽类似物的药物组合物。 此外，肽类似物被给予患有多发性硬化症的患者。

公开(公告)号：US06329499B1

公开(公告)日：2001-12-11

申请号：US08342408

申请日：1994-11-18

申请人： Nicholas Ling ,  Amitabh Gaur ,  Paul J. Conlon ,  Lawrence Steinman

发明人： Nicholas Ling ,  Amitabh Gaur ,  Paul J. Conlon ,  Lawrence Steinman

IPC分类号： A61K3808

CPC分类号： C07K14/4713 ,  A61K38/00

摘要： The present invention is directed toward peptide analogues of human myelin basic protein. The peptide analogue is at least seven amino acids long and derived from residues 86 to 99 of human myelin basic protein. The analogues are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogues are provided. The peptide analogues are useful for treating multiple sclerosis.

摘要翻译： 本发明涉及人髓磷脂碱性蛋白的肽类似物。 肽类似物长至少七个氨基酸，并衍生自人髓磷脂碱性蛋白质的残基86至99。 至少在91,95或97位，类似物从天然序列改变。可以在其它位置进行其它改变。 提供了含有这些肽类似物的药物组合物。 肽类似物可用于治疗多发性硬化。

公开(公告)号：US5939400A

公开(公告)日：1999-08-17

申请号：US606639

申请日：1996-02-26

申请人： Lawrence Steinman ,  Ari Waisman

发明人： Lawrence Steinman ,  Ari Waisman

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  C07K14/725 ,  C12Q1/68 ,  A01N43/04 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/7051 ,  A61K2039/51 ,  A61K38/00

摘要： A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.

摘要翻译： 通过注射到编码T细胞受体的可变区的DNA的接收者来特异性地预防促炎T反应。 响应于接种，表达可变区的T细胞产生Th2细胞因子，包括IL-4。 针对自身抗原的促炎T细胞应答被DNA接种抑制。 抑制性疫苗接种进一步降低了用于疫苗接种的可变区未识别的自身抗原表位的T细胞的抗炎作用。

公开(公告)号：US4695459A

公开(公告)日：1987-09-22

申请号：US686126

申请日：1984-12-26

申请人： Lawrence Steinman ,  Matthew K. Waldor ,  Subramanian Sriram ,  Leonard A. Herzenberg ,  Leonore A. Herzenberg

发明人： Lawrence Steinman ,  Matthew K. Waldor ,  Subramanian Sriram ,  Leonard A. Herzenberg ,  Leonore A. Herzenberg

IPC分类号： C12N15/02 ,  A61K39/395 ,  A61P37/06 ,  C07K16/28 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  A61K35/56

CPC分类号： C07K16/2812 ,  Y10S424/81 ,  Y10S514/825 ,  Y10S514/863 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S530/868

摘要： Certain autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus may be prevented or attenuated by in vivo treatment with a complement-fixing anti-Leu3 (CD4) antibody that is cytotoxic to Leu3 (CD4) phenotype T cells.

摘要翻译： 某些自身免疫性疾病如多发性硬化症，类风湿性关节炎和系统性红斑狼疮可以通过使用对Leu3（CD4）表型T细胞具有细胞毒性的补体固定抗Leu3（CD4）抗体的体内治疗来预防或减弱。