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公开(公告)号：US20090264515A1
公开(公告)日：2009-10-22
申请号：US12467866
申请日：2009-05-18
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
IPC分类号： A61K31/7088 , A61P21/00
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译： 本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法， 所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。 施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答 （s）表示自我向量的管理。 本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病 其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。
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公开(公告)号：US20090281170A1
公开(公告)日：2009-11-12
申请号：US12467857
申请日：2009-05-18
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
IPC分类号： A61K31/711
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
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公开(公告)号：US07544669B2
公开(公告)日：2009-06-09
申请号：US10302098
申请日：2002-11-21
申请人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
发明人： Paulo Fontoura , Hideki Garren , William H. Robinson , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz
CPC分类号： A61K39/001 , A61K38/2026 , A61K39/0007 , A61K39/0008 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55561 , C07K2319/30
摘要： This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), -polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
摘要翻译： 本发明提供了一种治疗或预防与一种或多种自身蛋白，多肽或肽存在或参与非生理过程的一种或多种自身相关的动物疾病的方法， 所述动物包括向所述动物施用包含编码与所述疾病相关的自身蛋白质多肽或多肽的多核苷酸的自身载体。 施用包含编码自身蛋白，多肽或多肽的多核苷酸的自身载体调节对自身蛋白质的多肽或肽的免疫应答 （s）表示自我向量的管理。 本发明还提供了一种组合物，其包含编码一种或多种自身蛋白质，多肽或多肽或多肽的多核苷酸，所述多肽或多肽在治疗动物中非生理性地存在，可用于治疗或预防相关疾病 其中存在于动物的非生理过程的和/或靶中的自身蛋白质，多肽或多肽。
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公开(公告)号：US07785819B2
公开(公告)日：2010-08-31
申请号：US10120578
申请日：2002-04-10
申请人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
发明人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
IPC分类号： G01N33/00
CPC分类号： A61K39/0008 , G01N33/564 , G01N33/6854 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.
摘要翻译： 本发明提供了确定个体中抗体特异性谱的方法。 该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。 阵列可以包括抗原和表位。 本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。
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公开(公告)号：US20100330110A1
公开(公告)日：2010-12-30
申请号：US12871765
申请日：2010-08-30
申请人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
发明人： William H. Robinson , David L. Hirschberg , Lawrence Steinman , Pedro Jose Ruiz , Paul J. Utz , Hideki Garren
CPC分类号： A61K39/0008 , G01N33/564 , G01N33/6854 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： This invention provides a method for determining the antibody specificity profile in an individual. This specificity profile reveals the individual's immune response to multiple antigens and/or epitopes of autoantigens, allergens, graft antigens, etc. The antibody specificity profile is determined through the binding of patient samples comprising antibodies to the arrays. The array can comprises antigens and epitopes. The invention also provides the means and methods for determining antigen or epitope specificity profiles that can be used in the development of either generic and individualized diagnosis and treatment for immune related diseases, including autoimmune disease, allergy and graft rejection.
摘要翻译： 本发明提供了确定个体中抗体特异性谱的方法。 该特异性特征揭示了个体对多种抗原和/或自身抗原，变应原，移植抗原等表位的免疫应答。通过将包含抗体的患者样品与阵列的结合来确定抗体特异性谱。 阵列可以包括抗原和表位。 本发明还提供了用于确定抗原或表位特异性谱的方法和方法，所述抗原或表位特异性特征可用于开发针对免疫相关疾病的通用和个体化诊断和治疗，包括自身免疫疾病，变态反应和移植排斥反应。
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公开(公告)号：US07070780B2
公开(公告)日：2006-07-04
申请号：US10152654
申请日：2002-05-20
申请人： Lawrence Steinman , Pedro Jose Ruiz
发明人： Lawrence Steinman , Pedro Jose Ruiz
CPC分类号： C07K14/4713 , A61K38/02 , A61K39/00
摘要： Compositions and methods are provided for the treatment of demyelinating autoimmune disease. Therapeutic doses are administered of an ordered peptide comprising a repeated motif {SEQ ID NO: 1} [1E2Y3Y4K]n, where n is from 2 to 6. Some specific peptides of interest include those having the sequence {SEQ ID NO:4} EYYKEYYKEYYK. The peptide may consist only of the ordered repeats, or may be extended at either termini by the addition of other amino acid residues. For therapy, the peptides may be administered topically or parenterally, e.g. by injection at a particular site, including subcutaneously, intraperitoneally, intravascularly, or the like or transdermally, as by electrotransport. In a preferred embodiment, subcutaneous injection is used to deliver the peptide. The subject methods are used for prophylactic or therapeutic purposes. The compositions of the invention may also contain other therapeutically active agents, e.g. immunosuppressants, β-interferon, steroids, etc.
摘要翻译： 提供组合物和方法用于治疗脱髓鞘性自身免疫性疾病。 给予治疗剂量的有序肽，其包含重复基序（SEQ ID NO：1）[SEQ ID NO：1] / SEQ ID NO：1 / 其中n为2至6.感兴趣的某些特定肽包括具有序列（SEQ ID NO：4）EYYKEYYYYYYK的那些。 肽可以仅由有序重复组成，或者可以通过加入其它氨基酸残基在任一末端延伸。 对于治疗，肽可以局部或肠胃外给药，例如， 通过在特定部位注射，包括皮下，腹膜内，血管内等或通过电转运进行皮下注射。 在优选的实施方案中，皮下注射用于递送肽。 本发明方法用于预防或治疗目的。 本发明的组合物还可以含有其它治疗活性剂，例如， 免疫抑制剂，β-干扰素，类固醇等
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