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公开(公告)号：US5747481A
公开(公告)日：1998-05-05
申请号：US863749
申请日：1997-05-27
申请人： Tine Krough J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
发明人： Tine Krough J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P3/14 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D413/06 , A61K31/40 , C07D207/12
CPC分类号： C07D401/06 , C07D211/60 , C07D413/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US20110009420A1
公开(公告)日：2011-01-13
申请号：US12883852
申请日：2010-09-16
申请人： Knud Erik Andersen
发明人： Knud Erik Andersen
IPC分类号： A61K31/496 , C07D241/04 , A61K31/495 , C07D401/14 , A61P25/28
CPC分类号： C07D295/104 , C07D209/18 , C07D307/85 , C07D333/70
摘要： The present invention provides compounds of the formula wherein R1, R2 and B are as herein described, pharmaceutical compositions comprising these compounds, use of these compounds for the preparation of pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of disorders and diseases wherein modulation of the H3 receptor is beneficial.
摘要翻译： 本发明提供下式的化合物，其中R1，R2和B如本文所述，包含这些化合物的药物组合物，这些化合物用于制备药物组合物的用途及其用于治疗和/或预防疾病的方法，以及 其中H3受体的调节是有益的疾病。
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公开(公告)号：US5919777A
公开(公告)日：1999-07-06
申请号：US842187
申请日：1997-04-23
IPC分类号： C07D241/04 , C07K5/065 , C07D241/08 , A61K31/495 , C07D401/12
CPC分类号： C07D241/04 , C07K5/06078
摘要： The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone.
摘要翻译： 本发明涉及可用于治疗由生长激素缺乏引起的医学疾病的通式I的新化合物。
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公开(公告)号：US5712292A
公开(公告)日：1998-01-27
申请号：US544905
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D207/08 , A61K31/40 , C07D211/32
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US07799924B2
公开(公告)日：2010-09-21
申请号：US11962455
申请日：2007-12-21
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07D401/04 , C07D413/04 , C07D413/06 , C07D413/14
摘要： A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the compounds possess histamine H3 receptor antagonistic activity and are thus useful in the treatment of disorders in which a histamine H3 receptor blockade is beneficial.
摘要翻译： 一类新的取代的高哌啶，哌啶和吡咯烷衍生物，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地，化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。
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公开(公告)号：US06174898B1
公开(公告)日：2001-01-16
申请号：US09066318
申请日：1998-04-28
申请人： Jan Ulrik Weis , Knud Erik Andersen
发明人： Jan Ulrik Weis , Knud Erik Andersen
IPC分类号： A01N4340
CPC分类号： A61K31/44 , A61K31/445 , Y02A50/421 , Y02A50/422
摘要： The present invention relates to a novel method for treating a mammal suffering from filariae.
摘要翻译： 本发明涉及治疗患有丝状疟原虫的哺乳动物的新方法
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公开(公告)号：US5817654A
公开(公告)日：1998-10-06
申请号：US790133
申请日：1997-01-29
申请人： Henning Thogersen , Birgit Sehested Hansen , Bernd Peschke , Thomas Kruse Hansen , Knud Erik Andersen
发明人： Henning Thogersen , Birgit Sehested Hansen , Bernd Peschke , Thomas Kruse Hansen , Knud Erik Andersen
IPC分类号： A61K31/55 , C07D223/14 , C07D403/10 , C07D413/14 , C07D223/16
CPC分类号： C07D403/10 , C07D223/14 , C07D413/14
摘要： The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.
摘要翻译： 本发明涉及新颖的N-取代的萘酚内酰胺及其下式的化合物：通式I的化合物具有刺激内源性生长激素释放的能力。 因此，这些化合物可用于治疗需要刺激生长激素产生或分泌的条件，例如在具有生长激素缺乏的人中或需要增加生长激素血浆水平的情况下，例如在老年患者或家畜中。
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公开(公告)号：US5693649A
公开(公告)日：1997-12-02
申请号：US544502
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US07332508B2
公开(公告)日：2008-02-19
申请号：US10735963
申请日：2003-12-15
IPC分类号： A61K31/454 , C07D43/02
CPC分类号： C07D401/04 , C07D413/04 , C07D413/06 , C07D413/14
摘要： A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the compounds possess histamine H3 receptor antagonistic activity and are thus useful in the treatment of disorders in which a histamine H3 receptor blockade is beneficial.
摘要翻译： 一类新的取代的高哌啶，哌啶和吡咯烷衍生物，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地，化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。
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公开(公告)号：US5795888A
公开(公告)日：1998-08-18
申请号：US544682
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , A61K31/645
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新型N-取代的氮杂杂环羧酸及其酯，其中N-取代基的取代烷基链或其盐，其制备方法，含有它们的组合物及其用于临床治疗的用途 疼痛，痛觉过敏和/或炎症状态，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。
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