公开(公告)号：US20050242281A1

公开(公告)日：2005-11-03

申请号：US10837205

申请日：2004-04-30

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/26 ,  H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/4255

Abstract: An unevenly segmented multipole is described. A mass spectrometer employing the unevenly segmented multipole is provided, as well as methods of analyzing ions by mass spectrometry using the unevenly segmented multipole.

Abstract translation: 描述了不均匀分段的多极。 提供了使用不均匀分段的多极的质谱仪，以及使用不均匀分段的多极分子质谱法分析离子的方法。

公开(公告)号：US06727495B2

公开(公告)日：2004-04-27

申请号：US10053077

申请日：2002-01-17

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J4940

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer comprising a drift tube having a central axis, along which a plurality of ring electrodes are arranged is provided. The plurality of ring electrodes provides a linear potential gradient along the central axis of the drift tube. In addition an RF voltage source coupled to the plurality of ring electrodes generates an oscillating RF potential within the internal region of each of the ring electrodes. The oscillating RF potential influences radial motion of the ions within the drift tube so that the ions remain within a radial space defined by the internal regions of the electrodes.

Abstract translation: 提供了一种离子迁移谱仪，其包括具有中心轴的漂移管，多个环形电极沿着该中心轴布置。 多个环形电极沿漂移管的中心轴提供线性电位梯度。 此外，耦合到多个环形电极的RF电压源在每个环形电极的内部区域内产生振荡RF电势。 振荡RF电位影响漂移管内的离子的径向运动，使得离子保持在由电极的内部区域限定的径向空间内。

公开(公告)号：US06570153B1

公开(公告)日：2003-05-27

申请号：US09691522

申请日：2000-10-18

Applicant: Gangqiang Li ,  Hongfeng Yin

Inventor： Gangqiang Li ,  Hongfeng Yin

IPC: H01J4942

CPC classification number: H01J49/4215 ,  H01J49/0081

Abstract: Apparatus and methods are disclosed for conducting procedures of tandem mass spectrometry using a single quadrupole mass analyzer. In one embodiment of the present invention a mass spectrometry apparatus comprises a single quadrupole mass analyzer having a first end opposite a second end. A source of charged particles is adjacent the first end of the quadrupole mass analyzer and a gate for controlling passage of charged particles is present between the source of charged particles and the first end. The apparatus further comprises a first element between the gate and the first end, a second element adjacent the second end, and a detector for detecting charged particles, or fragments thereof, exiting the quadrupole mass analyzer. In a method in accordance with the invention, charged particles from a source thereof are directed into the quadrupole mass analyzer to select charged particles by their mass to charge ratio. The selected charged particles are directed to a zone adjacent the quadrupole mass analyzer to subject the selected charged particles to collisional forces to form fragments thereof, which are temporarily stored in the zone. To separate the fragments, the fragments are directed from the zone into the quadrupole mass analyzer in a direction opposite to the direction of the charged particles introduced from the source. The fragments are then detected.

Abstract translation: 公开了使用单个四极杆质谱仪进行串联质谱法的装置和方法。 在本发明的一个实施方案中，质谱装置包括具有与第二端相对的第一端的单个四极质量分析器。 带电粒子的源极与四极质量分析器的第一端相邻，并且在带电粒子源和第一端之间存在用于控制带电粒子通过的栅极。 该装置还包括在栅极和第一端之间的第一元件，与第二端相邻的第二元件和用于检测离开四极质量分析器的带电粒子或其碎片的检测器。 在根据本发明的方法中，将来自其源的带电粒子引入四极质量分析器中以通过其质荷比选择带电粒子。 所选择的带电粒子被引导到与四极质量分析器相邻的区域，以使所选择的带电粒子受到碰撞力以形成其临时存储在该区域中的碎片。 为了分离碎片，片段以与从源引入的带电粒子的方向相反的方向从区域导入四极质量分析器。 然后检测碎片。

公开(公告)号：US06222186B1

公开(公告)日：2001-04-24

申请号：US09104754

申请日：1998-06-25

Applicant: Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

Inventor： Gangqiang Li ,  Thomas P. Doherty ,  Carl A. Myerholtz

IPC: H01J4900

CPC classification number: H01J49/105

Abstract: A technique that modulates the power of a inductively coupled plasma (ICP) according to the operative modes of a spectrometer. An analytical apparatus of the present invention contains an inductively coupled plasma generator (ICPG) and a spectrometer. The ICPG generates a plasma for forming ionic and excited molecular species from a sample. The spectrometer analyzes the ionic and excited molecular species formed. The spectrometer operates in an analysis mode wherein the ionic and excited molecular species are identified according to physical characteristics of the species to provide data on the species and further has a washout mode wherein the spectrometer flushes out interfering ions and molecules and provides no significant data on the sample. The controller modulates the ICPG to operate in power cycles, at each cycle the ICPG operates in an analysis period and a stand-by period. By modulating the plasma power, the power consumption and heat dissipation can be reduced. When such a power modulated plasma source is coupled to, for example, a time-of-flight mass spectrometer (TOFMS), high analytical performance can be achieved with simultaneous multi-element detection capability.

Abstract translation: 根据光谱仪的操作模式调制感应耦合等离子体（ICP）的功率的技术。 本发明的分析装置包含电感耦合等离子体发生器（ICPG）和光谱仪。 ICPG产生用于从样品形成离子和激发的分子物质的等离子体。 光谱仪分析形成的离子和激发的分子物质。 光谱仪以分析模式工作，其中根据物种的物理特性鉴定离子和激发的分子种类，以提供物种数据，并且还具有洗脱模式，其中光谱仪冲洗干扰离子和分子，并且不提供关于 例子。 控制员调控ICPG在动力循环中运行，ICPG在分析周期和待机期间运行的每个周期。 通过调制等离子体功率，可以降低功耗和散热。 当这种功率调制等离子体源耦合到例如飞行时间质谱仪（TOFMS）时，可以通过同时多元素检测能力实现高分析性能。

公开(公告)号：US5654543A

公开(公告)日：1997-08-05

申请号：US552041

申请日：1995-11-02

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: G01N27/62 ,  H01J49/40 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/488 ,  H01J49/401

Abstract: A time-of-flight mass spectrometer is disclosed having improved signal to noise characteristics and the ability to reject specific signal ions. The mass spectrometer includes a plasma source that generates the ions, a ion pulser that directs ions toward an ion detector, and a retarding grid assembly charged to repel noise ions. The retarding grid assembly maintains at least a predetermined minimum potential sufficient to repel all ions, except those which have been deliberately sampled by a deliberate pulse of the ion pulser. As a result, noise ions which unintentionally escape the ion pulser are repelled by the retarding grid assembly, and mass peaks are more easily detected and distinguished from background noise. Specific ions of the desired signal are also selectively rejected by stepping up the potential of the retarding grid assembly at a predetermined time calculated to correspond to the time-of-flight of the specific ions from the ion pulser. A grounded grid is also provided to maintain a field-free region away from the retarding grid assembly, such that rejection of ions may be tailored to a narrow range of ion masses.

Abstract translation: 公开了一种具有改进的信噪比特性和拒绝特定信号离子的能力的飞行时间质谱仪。 质谱仪包括产生离子的等离子体源，将离子引向离子检测器的离子脉冲发生器和充电以排斥噪声离子的延迟栅组件。 延迟栅格组件保持至少一个足以排斥所有离子的预定最小电位，除了已经通过离子脉冲发生器的故意脉冲故意采样的那些。 结果，无意中逃离离子脉冲发生器的噪声离子被延迟栅格组件排斥，并且质量峰值更容易被检测并与背景噪声区分开。 期望信号的特定离子也被选择性地拒绝，通过在预定时间内加速延迟电网组件的电位，其计算为对应于来自离子脉冲发生器的特定离子的飞行时间。 还提供接地格栅以保持无场区域远离延迟栅格组件，使得可以将离子的排斥调整到窄范围的离子质量。