公开(公告)号：US08206745B2

公开(公告)日：2012-06-26

申请号：US13158137

申请日：2011-06-10

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： A61K9/14 ,  A61K45/00 ,  A61K38/47 ,  A61K38/00

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

公开(公告)号：US20120094552A1

公开(公告)日：2012-04-19

申请号：US13265365

申请日：2010-04-13

申请人： Heinz Reibke ,  Rudolf Merz ,  Guohua Chen ,  Carsten Lückheide

发明人： Heinz Reibke ,  Rudolf Merz ,  Guohua Chen ,  Carsten Lückheide

IPC分类号： H01R13/02

CPC分类号： H01R13/748 ,  H01R9/18

摘要： An electric terminal for leading a conductor through a wall (1), comprising a first terminal piece (2) to be mounted on a first side (3) of the wall (1), and a second terminal piece (4) to be mounted on the second side (5) of the wall (1) is provided. The second terminal piece (4) or the first terminal piece (2) can be fastened to the wall (1) using a fastening means (6) that can be inserted through the wall (1) into the first terminal piece (2) or the second terminal piece (4) from the first side (3) or the second side (5) of the wall (1), and/or the fastening means (6) can be interlocked with the second terminal piece (4) or the first terminal piece (2) in such a way that to the second terminal piece (4) or the first terminal piece (2) can be fastened to the wall (1) from the second side (5) or the first side (3) of the wall (1). According to the invention, such an electric terminal for leading a conductor through a wall (1) can be fastened to the wall (1) in a particularly simple fashion.

摘要翻译： 一种用于引导导体穿过壁（1）的电端子，包括要安装在壁（1）的第一侧（3）上的第一端子件（2）和待安装的第二端子件（4） 在壁（1）的第二侧（5）上。 第二端子件（4）或第一端子件（2）可以使用能够穿过壁（1）插入到第一端子件（2）中的紧固装置（6）而紧固到壁（1），或 来自第一侧（3）或壁（1）的第二侧（5）的第二端子件（4）和/或紧固装置（6）可以与第二端子件（4）或 第一端子片（2）以从第二侧（5）或第一侧（3）可以将第二端子片（4）或第一端子片（2）固定到壁（1） 的墙（1）。 根据本发明，用于引导导体穿过壁（1）的这种电端子可以以特别简单的方式固定到壁（1）上。

公开(公告)号：US20110264077A1

公开(公告)日：2011-10-27

申请号：US13158137

申请日：2011-06-10

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： A61M37/00 ,  A61K38/02

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

摘要翻译： 能够悬浮活性剂的非水性单相载体。 非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。 所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯， 不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。 在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。 还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

公开(公告)号：US20050107772A1

公开(公告)日：2005-05-19

申请号：US10953895

申请日：2004-09-29

申请人： Guohua Chen ,  Rupal Ayer ,  Scott Lautenbach

发明人： Guohua Chen ,  Rupal Ayer ,  Scott Lautenbach

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M5/145

CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M5/145 ,  A61M2005/14513

摘要： In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.

摘要翻译： 一方面，本发明涉及一种渗透泵，其随着渗透泵在操作环境中的功能而自动提供活性剂的上升释放速率，并且可被设计用于植入期望的动物或人类受试者内。 根据本发明的渗透泵包括储存器，速率控制膜，可膨胀渗透组合物，活性剂制剂和出口孔。 一旦施用于操作环境，水通过速率控制膜并进入渗透组合物，其导致渗透组合物通过出口孔膨胀并排出活性剂制剂，速率与其速率成正比 水通过速率控制膜。 根据本发明的渗透泵允许通过速率控制膜的水流自动增加，而不需要在给药后操纵渗透泵。 随着通过速率控制膜的水流量增加，活性剂从渗透泵输送的速率也将成比例地增加。

公开(公告)号：US20050106214A1

公开(公告)日：2005-05-19

申请号：US10985122

申请日：2004-11-10

申请人： Guohua Chen

发明人： Guohua Chen

IPC分类号： A61K9/14 ,  A61K38/27 ,  A61K47/30

CPC分类号： A61K9/0024 ,  A61K47/34

摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

公开(公告)号：US09234068B2

公开(公告)日：2016-01-12

申请号：US12285372

申请日：2008-10-02

申请人： Caideng Yuan ,  Guohua Chen ,  Xixiang Zhang ,  Zongjin Li ,  Zhimeng Liu

发明人： Caideng Yuan ,  Guohua Chen ,  Xixiang Zhang ,  Zongjin Li ,  Zhimeng Liu

IPC分类号： C08G18/08 ,  C08G18/62 ,  C08G18/12 ,  C08G18/66 ,  C08G18/67 ,  C08G18/75 ,  C08G18/76 ,  C09D175/04

CPC分类号： C08G18/6254 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/6692 ,  C08G18/675 ,  C08G18/755 ,  C08G18/7621 ,  C08G2270/00 ,  C09D175/04 ,  C08G18/3228 ,  C08G18/62

摘要： A novel method for the preparation of an aqueous polyacrylate modified polyurethane dispersion is disclosed. The preparation method includes three main steps: a) preparation of polyacrylate polymer or copolymer emulsion; b) preparation of polyurethane prepolymer with carboxylic groups and neutralization treatment to the carboxylic groups; and c) dispersion and chain-extension of polyurethane prepolymer by adding the polyacrylate emulsion into the polyurethane prepolymer under vigorous agitation, or other mechanical operation. The aqueous polyacrylate modified polyurethane dispersion has self-crosslinkability when an unsaturated acetoacetoxy compound is used for the preparation of the polyacrylate emulsion.

公开(公告)号：US08460694B2

公开(公告)日：2013-06-11

申请号：US13647228

申请日：2012-10-08

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： A61F2/00 ,  A61K9/22 ,  A61K9/14 ,  A61K45/00 ,  A61K38/00

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

公开(公告)号：US08440226B2

公开(公告)日：2013-05-14

申请号：US13526375

申请日：2012-06-18

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： A61K9/14 ,  A61K45/00 ,  A61K38/00

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

公开(公告)号：US20130035670A1

公开(公告)日：2013-02-07

申请号：US13647228

申请日：2012-10-08

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： A61M5/168 ,  B23P11/00

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

公开(公告)号：US20130034210A1

公开(公告)日：2013-02-07

申请号：US13647873

申请日：2012-10-09

申请人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

发明人： Catherine M. Rohloff ,  Guohua Chen ,  Andrew S. Luk ,  Rupal A. Ayer ,  Paul R. Houston ,  Michael A. Desjardin ,  Pauline Zamora ,  Stan Lam

IPC分类号： G01N23/04

CPC分类号： A61K38/21 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/10 ,  A61K38/043 ,  A61K38/085 ,  A61K38/09 ,  A61K38/105 ,  A61K38/11 ,  A61K38/1808 ,  A61K38/185 ,  A61K38/191 ,  A61K38/2242 ,  A61K38/225 ,  A61K38/24 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K38/35 ,  A61K38/36 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  Y10T29/494 ,  Y10T29/49826

摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

摘要翻译： 能够悬浮活性剂的非水性单相载体。 非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。 所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯， 不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。 在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。 还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。