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    Medicinal composition for prevention or treatment of parasitic protozoan infection
    51.
    发明授权
    Medicinal composition for prevention or treatment of parasitic protozoan infection 有权
    用于预防或治疗寄生原生动物感染的药物组合物

    公开(公告)号：US08193224B2

    公开(公告)日：2012-06-05

    申请号：US11576429

    申请日：2005-09-30

    申请人： Masataka Ihara ,  Kiyosei Takasu ,  Khanitha Pudhom ,  Hiroshi Kitaguchi ,  Masayuki Kawakami ,  Kozo Sato

    发明人： Masataka Ihara ,  Kiyosei Takasu ,  Khanitha Pudhom ,  Hiroshi Kitaguchi ,  Masayuki Kawakami ,  Kozo Sato

    IPC分类号： A61K31/427 ,  A61K31/428 ,  C07D277/66 ,  C07D277/04 ,  C07D277/84

    CPC分类号： C07D277/84 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  C07D277/64 ,  C07D417/14 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414

    摘要： The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or —NR1— (R1 represents an alkyl group, aryl group or heterocyclic group); L1, L2, L3, L4 and L5 each independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less).

    摘要翻译： 本发明提供一种用于预防或治疗对寄生原虫感染具有高选择性毒性的寄生原虫感染的药物组合物，以及优异的预防或治疗效果。 用于预防或治疗寄生原生动物感染的药物组合物包含由以下通式（1）表示的化合物作为活性成分（其中R表示烷基，芳基或杂环基; A和B各自独立地表示5-或 含有至少一个杂原子的6元环或其中1个以上3〜8元环稠合的缩合环; Y表示S，O，Se或-NR1-（R1表示烷基，芳基 基团或杂环基）; L1，L2，L3，L4和L5各自独立地表示次甲基; Q表示生理上可接受的阴离子; k表示使整个分子0的电荷所必需的0至2的整数; p和q各自表示0〜3的整数，p和q的和为1以上且6以下）。

    RADIOLOGICAL IMAGING APPARATUS
    52.
    发明申请
    RADIOLOGICAL IMAGING APPARATUS 有权
    放射成像装置

    公开(公告)号：US20100054571A1

    公开(公告)日：2010-03-04

    申请号：US12614933

    申请日：2009-11-09

    申请人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

    发明人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

    IPC分类号： G06K9/00

    CPC分类号： G01T1/1611 ,  A61B6/037 ,  A61B6/4241 ,  A61B6/5235 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  G01T1/2985 ,  Y10S378/901

    摘要： A radiological imaging apparatus of the present invention comprises an image pickup device and a medical examinee holding device that is provided with a bed. The image pickup device includes a large number of radiation detectors and radiation detector support plates. A large number of radiation detectors are mounted around the circumference of a through-hole and arranged in the axial direction of the through-hole. The radiation detectors are arranged in three layers formed radially with respect to the center of the through-hole and mounted on the lateral surfaces of the radiation detector support plates. Since the radiation detectors are not only arranged in the axial direction and circumferential direction of the through-hole but also arrayed in the radial direction, it is possible to obtain accurate information about a γ-ray arrival position in the radial direction of the through-hole (the positional information about a radiation detector from which a γ-ray image pickup signal is output). The use of accurate information about γ-ray arrival increases the tomogram accuracy. As a result, the present invention enhances the tomogram accuracy, that is, the PET examination accuracy.

    摘要翻译： 本发明的放射学成像装置包括：图像拾取装置和设有床的医疗检查者保持装置。 图像拾取装置包括大量的辐射检测器和辐射检测器支撑板。 大量的辐射探测器安装在通孔的圆周周围并沿通孔的轴向布置。 辐射检测器被布置成相对于通孔的中心径向形成的三层，并且安装在辐射检测器支撑板的侧表面上。 由于辐射检测器不仅沿通孔的轴向和圆周方向布置，而且沿径向排列，可以获得关于通孔的径向上的γ射线到达位置的准确信息， （关于从其输出γ射线摄像信号的放射线检测器的位置信息）。 使用关于γ射线到达的准确信息可以增加断层图像的准确性。 结果，本发明增强了断层图像精度，即PET检查精度。

    Radiological imaging apparatus
    53.
    发明授权
    Radiological imaging apparatus 有权
    放射成像装置

    公开(公告)号：US07634048B2

    公开(公告)日：2009-12-15

    申请号：US12331299

    申请日：2008-12-09

    申请人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

    发明人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

    IPC分类号： A61B6/00

    CPC分类号： G01T1/1611 ,  A61B6/037 ,  A61B6/4241 ,  A61B6/5235 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  G01T1/2985 ,  Y10S378/901

    摘要： A radiological imaging apparatus of the present invention comprises an image pickup device and a medical examinee holding device that is provided with a bed. The image pickup device includes a large number of radiation detectors and radiation detector support plates. A large number of radiation detectors are mounted around the circumference of a through-hole and arranged in the axial direction of the through-hole. The radiation detectors are arranged in three layers formed radially with respect to the center of the through-hole and mounted on the lateral surfaces of the radiation detector support plates. Since the radiation detectors are not only arranged in the axial direction and circumferential direction of the through-hole but also arrayed in the radial direction, it is possible to obtain accurate information about a γ-ray arrival position in the radial direction of the through-hole (the positional information about a radiation detector from which a γ-ray image pickup signal is output). The use of accurate information about γ-ray arrival increases the tomogram accuracy. As a result, the present invention enhances the tomogram accuracy, that is, the PET examination accuracy.

    摘要翻译： 本发明的放射学成像装置包括：图像拾取装置和设有床的医疗检查者保持装置。 图像拾取装置包括大量的辐射检测器和辐射检测器支撑板。 大量的辐射探测器安装在通孔的圆周周围并沿通孔的轴向布置。 辐射检测器被布置成相对于通孔的中心径向形成的三层，并且安装在辐射检测器支撑板的侧表面上。 由于辐射检测器不仅沿着通孔的轴向方向和圆周方向布置，而且沿径向排列，可以获得关于通孔的径向方向上的伽马射线到达位置的准确信息， （关于从其输出伽马射线摄像信号的放射线检测器的位置信息）。 使用关于伽马射线到达的准确信息增加了断层图像的准确性。 结果，本发明增强了断层图像精度，即PET检查精度。

    Radiation detection apparatus and radiological imaging apparatus
    54.
    发明授权
    Radiation detection apparatus and radiological imaging apparatus 有权
    放射线检测装置和放射线成像装置

    公开(公告)号：US07528378B2

    公开(公告)日：2009-05-05

    申请号：US11714216

    申请日：2007-03-06

    申请人： Kazuma Yokoi ,  Hiroshi Kitaguchi ,  Katsutoshi Tsuchiya ,  Takafumi Ishitsu ,  Kensuke Amemiya

    发明人： Kazuma Yokoi ,  Hiroshi Kitaguchi ,  Katsutoshi Tsuchiya ,  Takafumi Ishitsu ,  Kensuke Amemiya

    IPC分类号： H01L27/146

    CPC分类号： G01T1/2928

    摘要： A radiological imaging apparatus comprising a semiconductor detector unit in which a plurality of semiconductor radiation detection elements are installed on a detector mounted substrate in a matrix to constitute a detector unit. A plurality of detector units are releasably mounted on a fixing substrate. This mounting is carried out mating a coupling screw with a threaded hole formed in the detector mounted substrate, the coupling screw being inserted through a through-hole formed in the fixing substrate. The detector mounted substrate is provided with a pair of positioning pins. The positioning pins are inserted into positioning holes, respectively, formed in the fixing substrate, to position the detector unit.

    摘要翻译： 一种放射成像装置，包括半导体检测器单元，其中多个半导体辐射检测元件以矩阵形式安装在检测器安装的基板上以构成检测器单元。 多个检测器单元可释放地安装在固定基板上。 该安装件将联接螺钉与形成在检测器安装的基板中的螺纹孔配合，该联接螺钉通过形成在固定基板中的通孔插入。 检测器安装的基板设有一对定位销。 定位销分别插入到形成在定影基板中的定位孔中，以定位检测器单元。

    Near infrared fluorescent contrast agent and method for fluorescence imaging
    57.
    发明授权
    Near infrared fluorescent contrast agent and method for fluorescence imaging 失效
    近红外荧光造影剂及荧光成像方法

    公开(公告)号：US07473415B2

    公开(公告)日：2009-01-06

    申请号：US10506819

    申请日：2003-03-07

    申请人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

    发明人： Masayuki Kawakami ,  Hiroshi Kitaguchi ,  Kai Licha ,  Christin Perlitz ,  Hiroaki Eguchi ,  Natsuko Tsuda ,  Kazuhiro Aikawa

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/0032 ,  A61K49/0052

    摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

    摘要翻译： 1.一种近红外荧光造影剂，其特征在于，在生物体组织中的透过性优异，能够对肿瘤和/或血管进行特异性成像，其特征在于，含有式（I）表示的化合物或其药学上可接受的盐，其中R1，R2，R7， 并且R 8表示C 1 -C 10烷基等; R3，R4，R5，R6，R9，R10，R11和R12表示氢原子，C1-C6烷基，芳基等; X1和X2表示C1-C15烷基或芳基，X1和X2总共具有0至4个羧基; m1，m2，m3表示0或1; L1至L7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。

    Semiconductor radiation detector and radiological imaging apparatus
    58.
    发明授权
    Semiconductor radiation detector and radiological imaging apparatus 失效
    半导体辐射探测器和放射成像设备

    公开(公告)号：US07446319B2

    公开(公告)日：2008-11-04

    申请号：US10874225

    申请日：2004-06-24

    申请人： Norihito Yanagita ,  Hiroshi Kitaguchi ,  Takafumi Ishitsu ,  Kensuke Amemiya ,  Yuuichirou Ueno ,  Katsutoshi Tsuchiya ,  Shinichi Kojima ,  Kazuma Yokoi

    发明人： Norihito Yanagita ,  Hiroshi Kitaguchi ,  Takafumi Ishitsu ,  Kensuke Amemiya ,  Yuuichirou Ueno ,  Katsutoshi Tsuchiya ,  Shinichi Kojima ,  Kazuma Yokoi

    IPC分类号： G01T1/164

    CPC分类号： G01T1/2928 ,  A61B6/037

    摘要： A radiation imaging apparatus with high spatial resolution including semiconductor radiation detectors arranged on a wiring board capable of detecting γ-rays by separating their positions in the direction of incidence of γ-rays is provided. A semiconductor radiation detector is constructed by including five semiconductor devices made up of, for example, CdTe rectangular parallelepiped plates, a cathode electrode on one side of the semiconductor device, an anode electrode on the other side of the semiconductor device and an insulator for coating five semiconductor detection devices from the outside. The semiconductor radiation detector is mounted on a wiring board using an anode pin and a cathode pin.

    摘要翻译： 提供了具有高空间分辨率的辐射成像装置，其包括布置在能够通过在伽马射线入射方向上分离它们的位置来检测伽马射线的布线板上的半导体辐射检测器。 半导体辐射检测器通过包括由例如CdTe长方体板构成的五个半导体器件，半导体器件的一侧上的阴极电极，半导体器件的另一侧的阳极电极和用于涂覆的绝缘体 五个半导体检测装置来自外部。 半导体辐射检测器使用阳极引脚和阴极引脚安装在布线板上。

    Coincidence counting method of γ ray and nuclear medicine diagnostic apparatus
    60.
    发明授权
    Coincidence counting method of γ ray and nuclear medicine diagnostic apparatus 失效
    伽马射线和核医学诊断仪器的一致性计数方法

    公开(公告)号：US07329873B2

    公开(公告)日：2008-02-12

    申请号：US10949403

    申请日：2004-09-27

    申请人： Norihito Yanagita ,  Yuuichirou Ueno ,  Kensuke Amemiya ,  Hiroshi Kitaguchi ,  Katsutoshi Tsuchiya ,  Shinichi Kojima ,  Kazuma Yokoi ,  Takafumi Ishitsu

    发明人： Norihito Yanagita ,  Yuuichirou Ueno ,  Kensuke Amemiya ,  Hiroshi Kitaguchi ,  Katsutoshi Tsuchiya ,  Shinichi Kojima ,  Kazuma Yokoi ,  Takafumi Ishitsu

    IPC分类号： G01T1/00

    CPC分类号： G01T1/172

    摘要： A γ-ray signal processing section 60′ determines a detection time of a γ ray based on a γ-ray detection signal outputted from a semiconductor radiation detector for detecting the γ ray, and determines the energy of the γ ray. Then, a time correction circuit 70 obtains, based on the energy of the γ ray, a detection value of the detection time that corresponds to the energy of the γ ray from a time correction table indicating the relationship between the energy of the γ ray and the correction value of the detection time of the γ ray, and corrects the detection time according to the obtained correction value of the detection time. Coincidence counting is performed on the γ ray in a coincidence counting circuit 80 based on the corrected detection time.

    摘要翻译： 伽马射线信号处理部60'基于从用于检测伽马射线的半导体辐射检测器输出的γ射线检测信号来确定伽马射线的检测时间，并且确定伽马射线的能量。 然后，时间校正电路70根据伽马射线的能量，从表示伽马射线的能量与γ射线的能量的关系的时刻校正表，求出与γ射线的能量对应的检测时间的检测值 伽马射线的检测时间的校正值，并根据获得的检测时间的校正值来校正检测时间。 基于校正的检测时间，在重合计数电路80中对伽马射线进行一致性计数。