公开(公告)号：US20110120868A1

公开(公告)日：2011-05-26

申请号：US12920809

申请日：2009-03-18

Applicant: Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

Inventor： Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

IPC: G01N27/447 ,  H05K3/06 ,  H05K3/02 ,  B82Y99/00

CPC classification number: C12Q1/6869 ,  B82Y15/00 ,  G01N33/48721 ,  C12Q2565/631

Abstract: The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

Abstract translation: 本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。 更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。 此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的 生物聚合物。

公开(公告)号：US07378386B2

公开(公告)日：2008-05-27

申请号：US10642117

申请日：2003-08-15

Applicant: Philip E. Thorpe ,  M. Melina Soares ,  Jin He

Inventor： Philip E. Thorpe ,  M. Melina Soares ,  Jin He

IPC: A61K38/00 ,  A61K31/00

CPC classification number: A61K51/088 ,  A61K39/395 ,  A61K39/39558 ,  A61K47/48415 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6835 ,  A61K47/6849 ,  A61K49/00 ,  A61K49/14 ,  A61K51/025 ,  A61K51/08 ,  A61K2039/505 ,  C07K2/00 ,  C07K7/64 ,  C07K16/18 ,  C07K16/2836 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

Abstract: Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

Abstract translation: 公开了关于阴离子磷脂和氨基磷脂在肿瘤脉管系统和病毒进入和扩散中的作用的令人惊奇的发现，以及将这些发现用于治疗癌症和病毒感染的组合物和方法。 还公开了结合和抑制阴离子磷脂和氨基磷脂的有利的抗体，免疫缀合物和基于杜氏霉素的组合物和组合，用于安全和有效治疗癌症，病毒感染和相关疾病。

公开(公告)号：US20060269518A1

公开(公告)日：2006-11-30

申请号：US10542461

申请日：2004-01-15

Applicant: Lung-Ji Chang ,  Jin He

Inventor： Lung-Ji Chang ,  Jin He

IPC: A61K48/00 ,  C12N15/867

CPC classification number: C12N15/1135 ,  A61K48/00 ,  C12N15/111 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2799/027

Abstract: Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.

Abstract translation: 通过向细胞中导入编码针对该基因特异的siRNA的慢病毒载体，在细胞中抑制基因表达。 编码针对癌症相关基因的siRNA的慢病毒载体抑制基因的表达，并在导入癌细胞后导致细胞死亡。 在将HIV基因特异性siRNA的慢病毒载体导入细胞后，HIV感染细胞中的病毒复制被抑制。

公开(公告)号：US6075716A

公开(公告)日：2000-06-13

申请号：US286856

申请日：1999-04-06

Applicant: Jin He ,  Mark E. Jacobs

Inventor： Jin He ,  Mark E. Jacobs

IPC: H02M7/12 ,  H02M1/00 ,  H02M1/42 ,  H02M3/155 ,  H02M1/12

CPC classification number: H02M1/4216 ,  H02M2001/009 ,  Y02B70/126

Abstract: For use with a three-phase split boost converter having a primary stage with a primary rectifier and first and second primary boost switches coupled between an input and first and second outputs of the three-phase split boost converter, an auxiliary stage interposed between the input and the first and second outputs, a method of reducing input current total harmonic distortion (THD) and a converter incorporating the auxiliary stage or the method. In one embodiment, the auxiliary stage includes: (1) first, second and third auxiliary boost inductors coupled to corresponding phases of the input and (2) an auxiliary boost network interposed between the first, second and third auxiliary boost inductors and the first and second outputs and including (2a) an auxiliary three phase full-wave rectifier, (2b) first and second auxiliary boost diodes, and (2c) first and second auxiliary boost switches, coupled between the auxiliary three phase full-wave rectifier and the first and second auxiliary boost diodes, that cooperate to conduct currents through the first, second and third auxiliary boost inductors to reduce input current total harmonic distortion (THD) at the input of the three-phase split boost converter.

Abstract translation: 用于具有初级级的初级整流器和耦合在三相分流式升压转换器的输入端和第一和第二输出端之间的第一和第二主级升压开关的三相分流升压转换器，插入在输入端之间的辅助级 以及第一和第二输出，减少输入电流总谐波失真（THD）的方法和结合辅助级的转换器或方法。 在一个实施例中，辅助级包括：（1）耦合到输入的相应相位的第一辅助升压电感器和第二辅助升压电感器，和（2）插入在第一辅助升压电感器和第二辅助升压电感器之间的辅助升压网络，以及 第二输出，包括（2a）辅助三相全波整流器，（2b）第一和第二辅助升压二极管，和（2c）第一和第二辅助升压开关，耦合在辅助三相全波整流器和第一 和第二辅助升压二极管，它们配合以通过第一，第二和第三辅助升压电感器传导电流，以减小三相分压升压转换器输入端的输入电流总谐波失真（THD）。

公开(公告)号：US6043997A

公开(公告)日：2000-03-28

申请号：US133105

申请日：1998-08-12

Applicant: Jin He ,  Mark E. Jacobs

Inventor： Jin He ,  Mark E. Jacobs

IPC: H02M1/14

CPC classification number: H02M1/4216 ,  H02M1/4225 ,  Y02B70/126

Abstract: For use with a three-phase boost converter having a primary stage with a primary rectifier and a primary boost switch coupled between an input and output of the three-phase boost converter, an auxiliary stage, method of reducing input current total harmonic distortion (THD) at the input of the three-phase boost converter, and a three-phase boost converter employing the auxiliary stage and method. In one embodiment, the auxiliary stage includes first, second and third auxiliary boost inductors coupled to corresponding phases of the input. The auxiliary stage also includes an auxiliary boost switch, interposed between the first, second and third auxiliary boost inductors and the output, that conducts to draw corresponding phase currents through the first, second and third auxiliary boost inductors thereby reducing input current THD at the input of the three-phase boost converter.

Abstract translation: 用于具有初级整流器和耦合在三相升压转换器的输入和输出之间的初级升压开关的三相升压转换器，辅助级，减少输入电流总谐波失真（THD）的方法 ）在三相升压转换器的输入端，以及采用辅助级和方法的三相升压转换器。 在一个实施例中，辅助级包括耦合到输入的相应相位的第一，第二和第三辅助升压电感器。 辅助级还包括插入在第一辅助升压电感器和第三辅助升压电感器之间的辅助升压开关和输出端，该辅助升压开关导通通过第一，第二和第三辅助升压电感器引出相应的相电流，从而减小输入端的输入电流THD 的三相升压转换器。

公开(公告)号：US6031739A

公开(公告)日：2000-02-29

申请号：US133068

申请日：1998-08-12

Applicant: Jin He ,  Mark E. Jacobs

Inventor： Jin He ,  Mark E. Jacobs

IPC: H02M1/00 ,  H02M1/42 ,  G05F1/613

CPC classification number: H02M1/4216 ,  Y02B70/126

Abstract: For use with a three-phase split boost converter having a primary stage with a primary rectifier and first and second primary boost switches coupled between an input and first and second outputs of the three-phase split boost converter, an auxiliary stage, method of reducing input current total harmonic distortion (THD) at the input of the three-phase split boost converter, and a three-phase split boost converter employing the auxiliary stage and method. In one embodiment, the auxiliary stage includes first, second and third auxiliary boost inductors coupled to corresponding phases of the input. The auxiliary stage also includes an auxiliary boost switch, interposed between the first, second and third auxiliary boost inductors and the first and second outputs of the split boost, that conducts to induce corresponding phase currents through the first, second and third auxiliary boost inductors thereby reducing input current THD at the input of the three-phase split boost converter.

Abstract translation: 用于具有初级级的初级整流器和耦合在三相分流升压转换器的输入端和第一和第二输出端之间的第一和第二主级升压开关的三相分流升压转换器，辅助级，减小 三相分压升压转换器输入端的输入电流总谐波失真（THD），以及采用辅助级和方式的三相分压升压转换器。 在一个实施例中，辅助级包括耦合到输入的相应相位的第一，第二和第三辅助升压电感器。 辅助级还包括插入在第一辅助升压电感器和第二辅助升压电感器之间的辅助升压开关以及分压升压器的第一和第二输出端，其通过第一，第二和第三辅助升压电感器导通相应的相电流，由此 减少三相分压升压转换器输入端的输入电流THD。

公开(公告)号：US5909108A

公开(公告)日：1999-06-01

申请号：US27579

申请日：1998-02-23

Applicant: Jin He ,  Mark E. Jacobs

Inventor： Jin He ,  Mark E. Jacobs

IPC: H02M3/158 ,  H03K17/08 ,  H03K17/082 ,  H03K17/12 ,  G05F1/613

CPC classification number: H03K17/127 ,  H02M3/1584 ,  H03K17/0828 ,  H03K17/122 ,  H03K2017/0806 ,  Y10S323/907

Abstract: For use in a switch-mode power converter including parallel-coupled first and second switches, the first switch having a temperature-dependent resistance, a circuit for, and method of, distributing current between the first and second switches. In one embodiment, the circuit includes a device having a temperature-dependent characteristic, in thermal communication with the first switch and electrically coupled to a gate of the first switch, that senses a temperature of the first switch, modulates an amplitude of a drive waveform applied to the gate based on the temperature and thereby redistributes the current.

Abstract translation: 为了在包括并联耦合的第一和第二开关的开关模式功率转换器中使用，第一开关具有温度依赖性电阻，电路和在第一和第二开关之间分配电流的方法。 在一个实施例中，电路包括具有与第一开关热连通并电耦合到第一开关的栅极的温度相关特性的器件，其感测第一开关的温度，调制驱动波形的幅度 基于温度施加到栅极，从而重新分布电流。

公开(公告)号：US5847548A

公开(公告)日：1998-12-08

申请号：US939075

申请日：1997-09-26

Applicant: Jin He ,  Mark E. Jacobs

Inventor： Jin He ,  Mark E. Jacobs

IPC: H02M1/34 ,  H02M3/158 ,  H03K17/0814 ,  G05F1/10

CPC classification number: H02M1/34 ,  H02M3/1584 ,  H03K17/08148 ,  H02M2001/346 ,  Y02B70/1491

Abstract: For use in a boost converter having first and second boost switches coupled in parallel, a snubber for, and method of, improving current sharing between the first and second boost switches. In one embodiment, the snubber includes: (1) first and second snubber inductors, series-coupled with the first and second boost switches, respectively, that limit a flow rate of the electrical current in the first and second switches, respectively, as a function of a rate of the flow and (2) a conductive path, including a first zener diode coupled to a first node between the first snubber inductor and the first boost switch and a second zener diode coupled to a second node between the second snubber inductor and the second boost switch, that conducts a turn-off energy of said first and second boost switches from the first and second nodes toward an output of the boost converter.

Abstract translation: 用于具有并联耦合的第一和第二升压开关的升压转换器，用于改善第一和第二升压开关之间的电流共享的缓冲器及其方法。 在一个实施例中，缓冲器包括：（1）分别与第一和第二升压开关串联耦合的第一和第二缓冲电感器，其将第一和第二开关中的电流的流率分别限制为 流动速率的函数和（2）导电路径，包括耦合到第一缓冲电感器和第一升压开关之间的第一节点的第一齐纳二极管和耦合到第二缓冲电感器之间的第二节点的第二齐纳二极管 以及第二升压开关，其将所述第一和第二升压开关的关断能量从第一和第二节点向升压转换器的输出传导。