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    Non Thermal Plasma Method to Prepare [11C] Methyl Iodide From [11C] Methane and Iodine Methane and Iodine
    52.
    发明申请
    Non Thermal Plasma Method to Prepare [11C] Methyl Iodide From [11C] Methane and Iodine Methane and Iodine 审中-公开
    从[11C]甲烷和碘甲烷和碘制备[11C]碘甲烷的非热等离子体法

    公开(公告)号：US20080306313A1

    公开(公告)日：2008-12-11

    申请号：US12097563

    申请日：2006-12-12

    申请人： Jonas Eriksson ,  Tor Kihlberg ,  Bengt Langstrom ,  Johan Ulin

    发明人： Jonas Eriksson ,  Tor Kihlberg ,  Bengt Langstrom ,  Johan Ulin

    IPC分类号： C07C17/35

    CPC分类号： C07B59/001 ,  C07B2200/05 ,  C07C17/10 ,  C07C19/07

    摘要： A method and an apparatus for preparing [11C]methyl iodide from [11C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [11C]methane used in the experiments was produced from [11C]carbon dioxide via reduction with hydrogen over nickel. [11C]Methyl iodide was obtained with a specific radioactivity of 412±32 GBq/μmol within 6 min from approximately 24 GBq of [11C]carbon dioxide. The decay corrected radiochemical yield was 13±3% based on [11C]carbon dioxide at start of synthesis. [11C]Flumazenil was synthesized via a N-alkylation with the prepared [11C]methyl iodide. Kit and apparatus for preparing [11C]methyl iodide by a non thermal plasma method are also provided.

    摘要翻译： 已经开发了通过非热等离子体反应器单次通过[11 C]甲烷和碘制备[11C]甲基碘的方法和装置。 通过在减压下的氦气流中的电极施加高电压（400V / 31kHz）来产生等离子体。 实验中使用的[11C]甲烷通过用氢还原镍从[11C]二氧化碳生产。 [11C]在大约24GBq [11C]二氧化碳的6分钟内，得到甲基碘，其特异放射性为412±32GBq / mumol。 在合成开始时，基于[11C]二氧化碳的衰变校正放射化学产率为13±3％。 [11C]通过N-烷基化与制备的[11 C]甲基碘合成氟马西尼。 还提供了通过非热等离子体法制备[11 C]甲基碘的试剂盒和装置。

    Method and System of Multivariate Analysis on Volume-Wise Data of Reference Structure Normalized Images for Improved Quality in Positron Emission Tomography Studies
    53.
    发明申请
    Method and System of Multivariate Analysis on Volume-Wise Data of Reference Structure Normalized Images for Improved Quality in Positron Emission Tomography Studies 失效
    参考结构体积智慧数据多元分析方法与系统正电子图像质量正电子发射断层扫描研究

    公开(公告)号：US20080279436A1

    公开(公告)日：2008-11-13

    申请号：US12065119

    申请日：2006-08-31

    申请人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    发明人： Pasha Razifar ,  Mats Bergstrom ,  Bengt Langstrom

    IPC分类号： G06K9/00

    CPC分类号： G01N23/00 ,  G06T5/002 ,  G06T5/008 ,  G06T7/0012 ,  G06T2207/10104 ,  G06T2207/30016

    摘要： A method and system are provided to mask out the background in dynamic PET images, to perform pre-normalization on the masked dynamic PET images, and to apply multivariate image analysis (e.g., principal component analysis PCA) on the masked pre-normalized dynamic PET images in order to improve the quality of the dynamic PET images and the PET study. A masking operation applies PCA to untreated dynamic PEET images before any pre-normalization in order to mask out the background pixels. This masking operation uses the Otsu method. A first normalization method is background noise pre-normalization where pixel values are corrected for background noise. A second normalization method is kinetic pre-normalization where the contrast within an image is improved. Multivariate analysis such as PCA may be applied on the whole volume to find the largest variance in the structure.

    摘要翻译： 提供了一种方法和系统来掩盖动态PET图像中的背景，对掩蔽的动态PET图像执行预归一化，并将多变量图像分析（例如主成分分析PCA）应用于掩蔽的预标准化动态PET 图像以提高动态PET图像和PET研究的质量。 屏蔽操作在任何预归一化之前将PCA应用于未处理的动态PEET图像，以便屏蔽背景像素。 该掩蔽操作使用Otsu方法。 第一归一化方法是对背景噪声校正像素值的背景噪声预归一化。 第二种归一化方法是动态预归一化，其中图像内的对比度得到改善。 多变量分析如PCA可以应用在整个体积上，以找出结构中最大的变化。

    Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase
    58.
    发明授权
    Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11C]carbon dioxide in a stationary gas-phase 失效
    在固定气相中使用纳摩尔浓度的[11C]二氧化碳进行微型化液体表面反应

    公开(公告)号：US08679452B2

    公开(公告)日：2014-03-25

    申请号：US12158712

    申请日：2006-12-19

    申请人： Tor Kihlberg ,  Bengt Langstrom

    发明人： Tor Kihlberg ,  Bengt Langstrom

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： C07B59/00 ,  C01B32/50

    摘要： Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

    摘要翻译： 提供了使用格氏试剂或其他有机金属试剂在可闭合的反应环路或反应器中用碳同位素标记的二氧化碳进行微型羧化的方法和试剂。 所得碳同位素标记的化合物可用作放射性药物或放射性药物的前体，特别用于正电子发射断层扫描（PET）。 还提供了用于PET研究的相关工具包。