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51.发明授权Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity 失效丙烯酰氧基-N-（氨基烷基）-1-吡咯烷和哌啶甲酰胺和具有抗心律失常活性的硫代酰胺
公开(公告)号：US4547514A
公开(公告)日：1985-10-15
申请号：US557885
申请日：1983-12-05
IPC分类号： A61K31/40 , A61K31/445 , A61P9/06 , C07D207/12 , C07D211/40 , C07D211/42 , C07D211/46 , A61K31/385 , A61K31/495 , A61K31/535
CPC分类号： C07D211/40 , C07D207/12 , C07D211/42 , C07D211/46 , Y10S514/821
摘要： Pharmaceutical compositions comprised of aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides are provided of the formula: ##STR1## wherein Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2,3-dihydro-1H-inden-4-yl, 2,3-dihydro-1H-inden-5-yl, phenyl, substituted phenyl wherein the substituents are selected from lower alkyl of from 1 to 8 carbon atoms, lower alkyloxy of from 1 to 8 carbon atoms, halogen and trifluoromethyl; m and n are 1 or 2 but are never 2 at the same time; p is 1, 2, 3 or 4; R is selected from hydrogen or lower alkyl of from 1 to 3 carbon atoms; R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl of from 1 to 8 carbon atoms, phenyl, phenyl lower alkyl of from 7 to 9 carbon atoms, and cycloalkyl of from 3 to 8 carbon atoms, and R.sup.1 and R.sup.2 taken together with the adjacent atom may form a heterocyclic residue selected from 4-morpholino, 1-pyrrolidino, 1-piperidino, 1-piperazino and 4-lower alkyl piperazin-1-yl; X is oxygen or sulfur; and the pharmaceutically acceptable acid addition salts thereof having antiarrhythmic activity.
摘要翻译： 由芳氧基-N-（氨基烷基）-1-吡咯烷和哌啶甲酰胺和硫代酰胺组成的药物组合物由下式提供：其中Ar选自1-萘基，2-萘基， 二氢-1H-茚-4-基，2,3-二氢-1H-茚-5-基，苯基，取代苯基，其中取代基选自1至8个碳原子的低级烷基，低级烷氧基为1至 8个碳原子，卤素和三氟甲基; m和n是1或2，但从不同时2; p为1,2,3或4; R选自氢或1至3个碳原子的低级烷基; R1和R2选自氢，1至8个碳原子的低级烷基，苯基，7至9个碳原子的苯基低级烷基和3至8个碳原子的环烷基，以及R1和R2与相邻的 原子可以形成选自4-吗啉代，1-吡咯烷子基，1-哌啶子基，1-哌嗪基和4-低级烷基哌嗪-1-基的杂环残基; X是氧或硫; 及其药学上可接受的酸加成盐具有抗心律不齐活性。
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公开(公告)号：USD267242S
公开(公告)日：1982-12-14
申请号：US108568
申请日：1979-12-31
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公开(公告)号：US4170960A
公开(公告)日：1979-10-16
申请号：US921484
申请日：1978-07-03
CPC分类号： F02M25/00 , F02B51/00 , F02F2007/0092
摘要： There is disclosed an engine additive supply and control device, for supplying a fuel supplement in small amounts which will have many desirable effects on operation of the vehicle or apparatus which is being driven by an engine to which the additive is being supplied along with the fuel and air mixture, the quantity of supply being controlled in response to manifold vacuum conditions and flow of additive through the device being controlled by passage way, opening and fluid line sizes, in the device, which are coordinated to prevent surging, flooding and to minimize consumption, while providing adequate quantities to produce the desired interaction with the fuel/air mixture, a container, a body with suitable wells and passages and interconnections being provided.
摘要翻译： 公开了一种发动机添加剂供应和控制装置，用于少量供应燃料补充剂，这将对由正在与燃料一起供应添加剂的发动机驱动的车辆或设备的操作产生许多期望的影响 和空气混合物，供应量根据歧管真空条件进行控制，并且通过装置的添加剂的流动由装置中的通道，开口和流体管线尺寸控制，其被协调以防止浪涌，溢流和最小化 消耗，同时提供足够的量以产生与燃料/空气混合物的期望的相互作用，容器，具有合适的井的主体和通道以及互连。
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公开(公告)号：US20240023667A1
公开(公告)日：2024-01-25
申请号：US17813529
申请日：2022-07-19
申请人： William L. Smith
发明人： William L. Smith
IPC分类号： A43B13/18
CPC分类号： A43B13/189
摘要： Provided are dynamic cushioning systems (e.g., for use in insoles, orthoses, shoes, etc.), comprising: a fluid chamber (e.g., 100, 200) having at least one flexible fluid reservoir cell in each of a hindfoot and a forefoot portion, and having at least one main fluid transfer channel spanning a midfoot portion and connecting, in fluid exchange communication, the at least one hindfoot fluid reservoir cell with the at least one forefoot fluid reservoir cell to provide a reactive network of hindfoot and/or forefoot fluid reservoir cells in fluid exchange communication. The interconnected multi-reservoir networks provide optimal reactivity and dynamic positional cushioning by controlling fluid transfer rate(s) between and among the fluid reservoir cells. Also provided are methods for making the fluid chambers, along with insoles, orthoses, shoes, and other footwear, etc., comprising same.
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公开(公告)号：US20190017880A1
公开(公告)日：2019-01-17
申请号：US15651025
申请日：2017-07-17
申请人： William L. Smith
发明人： William L. Smith
摘要： A temperature sensor assembly is described that includes a sensor probe including a probe head and a probe shaft. At least a tip of the sensor probe includes a material with a thermal conductivity proportionality constant greater than stainless steel. A temperature sensor is positioned within the probe shaft adjacent to the tip. A nose piece is positioned on the probe shaft opposite the probe head. The nose piece includes a material with a thermal conductivity proportionality constant greater than stainless steel. The temperature sensor assembly also includes a collar positioned around the probe shaft between the probe head and the nose piece, the collar is capable of rotating relative to the probe shaft during installation of the sensor assembly.
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公开(公告)号：US08642527B2
公开(公告)日：2014-02-04
申请号：US11764621
申请日：2007-06-18
IPC分类号： C11D7/60
CPC分类号： C11D3/3953 , A01N59/00 , B82Y30/00 , C11D3/1213 , C11D3/3956 , C11D7/20 , C11D11/0047 , C11D17/06
摘要： The invention provides an aqueous bleaching solution for substrate treatment. The aqueous bleaching solution features a source of oxidant and a plurality of optically functional nanoparticles. The optically functional nanoparticles are nanoparticles in the range of about 0.1 nanometers to about 400 nanometers in size. The aqueous bleaching solution may optionally include one or more an oxidant-stable surfactants and optionally, one or more oxidant-stable polymers, and adjuncts. The optically functional nanoparticles are extremely stable in the aqueous bleaching solution and remain substantially suspended in the aqueous bleaching solution due to their extremely small size despite having an average density greater than that of the bleaching solution. The optically functional nanoparticles provide at least one optical functional benefit to the bleaching solution owing to their uniform and stable suspension throughout the solution, including such benefits as uniform light absorption, light and radiation scattering, fluorescent emission, phosphorescent emission, coloration, and visual aesthetic benefits and the like. Further, optically functional benefits include those benefits provided to a substrate or surface treated with the aqueous bleaching solutions whereby the optically functional property is transferred either temporarily or permanently to the substrate or surface following contact with bleaching solutions containing the optically functional nanoparticles.
摘要翻译： 本发明提供了用于底物处理的水性漂白溶液。 含水漂白溶液具有氧化剂源和多个光学功能纳米颗粒。 光学功能纳米颗粒是尺寸在约0.1纳米至约400纳米范围内的纳米颗粒。 含水漂白溶液可以任选地包括一种或多种氧化剂稳定的表面活性剂和任选的一种或多种氧化剂稳定的聚合物和助剂。 光学功能性纳米粒子在水性漂白溶液中非常稳定，并且由于其极小的尺寸而保持基本上悬浮在含水漂白溶液中，尽管其平均密度大于漂白溶液的平均密度。 光学功能纳米颗粒由于其在整个溶液中均匀稳定的悬浮液而对漂白溶液提供至少一种光学功能有益效果，包括均匀的光吸收，光和辐射散射，荧光发射，磷光发射，着色和视觉美学等优点 利益等。 此外，光学功能优点包括提供给用水性漂白溶液处理的底物或表面的那些益处，由此在与含有光学功能纳米颗粒的漂白溶液接触之后光学功能性质暂时或永久地转移到基底或表面。
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公开(公告)号：US08287755B2
公开(公告)日：2012-10-16
申请号：US12620932
申请日：2009-11-18
CPC分类号： C11D3/10 , C11D3/2079 , C11D3/2082 , C11D3/33 , C11D3/349 , C11D3/3761 , C11D3/3776 , C11D3/378 , C11D3/3953 , C11D17/0039 , C11D17/0078
摘要： The present invention provides a solid-layered composition having at least two parts. The first part comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a surfactant, b) a builder, c) an acid, and d) wherein the second part does not contain any oxidant.
摘要翻译： 本发明提供具有至少两部分的固体层组合物。 第一部分包括a）次氯酸钙，次氯酸镁及其混合物，b）助洗剂，c）水溶性聚合物，d）酸和e）其中第一部分不含次氯酸钠，次氯酸锂，钾 次氯酸盐及其混合物。 第二部分包括a）表面活性剂，b）助洗剂，c）酸，和d）其中第二部分不含任何氧化剂。
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公开(公告)号：US20110059882A1
公开(公告)日：2011-03-10
申请号：US12943185
申请日：2010-11-10
申请人： William L. Smith , Evan Rumberger
发明人： William L. Smith , Evan Rumberger
CPC分类号： C11D3/10 , A61K8/19 , A61K8/20 , A61K8/36 , A61K8/463 , A61K8/466 , A61K8/8147 , A61K8/8152 , A61K8/8176 , A61K8/8188 , A61K2800/88 , A61Q11/02 , C11D1/22 , C11D3/046 , C11D3/2075 , C11D3/2079 , C11D3/2082 , C11D3/33 , C11D3/3454 , C11D3/349 , C11D3/361 , C11D3/3761 , C11D3/3776 , C11D3/378 , C11D3/3953 , C11D17/0078
摘要： The present invention provides a method for cleaning dentures by contacting the dentures with a solid, multi-layered composition having at least two parts in water. The first part of the composition comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a functional ingredient, b) a builder or filler, and c) wherein the second part does not contain any oxidant.
摘要翻译： 本发明提供一种通过使假牙与固体多层组合物接触来清洁义齿的方法，所述组合物在水中具有至少两个部分。 组合物的第一部分包括a）次氯酸钙，次氯酸镁及其混合物，b）助洗剂，c）水溶性聚合物，d）酸，和e）其中第一部分不含有次氯酸钠，锂 次氯酸盐，次氯酸钾及其混合物。 第二部分包括a）功能成分，b）助洗剂或填料，和c）其中第二部分不含任何氧化剂。
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公开(公告)号：US20110052726A1
公开(公告)日：2011-03-03
申请号：US12943117
申请日：2010-11-10
申请人： William L. Smith , Evan Rumberger
发明人： William L. Smith , Evan Rumberger
CPC分类号： C11D3/3951 , C11D3/10 , C11D3/2079 , C11D3/2082 , C11D3/33 , C11D3/349 , C11D3/3761 , C11D3/3776 , C11D3/378 , C11D3/3953 , C11D17/0039 , C11D17/0078
摘要： The present invention provides a solid-layered composition having at least two parts. The first part comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a functional ingredient, b) a builder or filler, and c) wherein the second part does not contain any oxidant.
摘要翻译： 本发明提供具有至少两部分的固体层组合物。 第一部分包括a）次氯酸钙，次氯酸镁及其混合物，b）助洗剂，c）水溶性聚合物，d）酸和e）其中第一部分不含次氯酸钠，次氯酸锂，钾 次氯酸盐及其混合物。 第二部分包括a）功能成分，b）助洗剂或填料，和c）其中第二部分不含任何氧化剂。
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公开(公告)号：US07890124B2
公开(公告)日：2011-02-15
申请号：US11536266
申请日：2006-09-28
申请人： William L. Smith , Steven Tischer
发明人： William L. Smith , Steven Tischer
IPC分类号： H04W24/00
CPC分类号： H04W4/02 , G06Q20/20 , G06Q30/02 , H04L67/18 , H04N21/25841 , H04N21/4882
摘要： Methods, systems, and computer-readable media are provided for location-based information delivery. One system described herein includes a matching server operative to identify a geographic area in which an informational message should be transmitted to subscriber devices located within the area. The geographic area may be a statically defined fixed geographic area, such as a neighborhood, that the matching server identifies utilizing one or more fixed geographic indicators. The geographic area identified by the matching server may alternatively be an ad-hoc variably sized geographic area. The matching server may utilize one or more variable geographic indicators to identify the geographic area. Once a geographic area has been identified, the matching server is operative to transmit an informational message to subscriber devices located within the geographic area. The informational message may contain content relevant to the geographic area.
摘要翻译： 提供方法，系统和计算机可读介质用于基于位置的信息传递。 本文描述的一个系统包括匹配服务器，其操作以识别其中信息消息应被发送到位于该区域内的用户设备的地理区域。 地理区域可以是静态定义的固定地理区域，例如邻域，匹配服务器使用一个或多个固定地理指标来识别。 由匹配服务器识别的地理区域可以替代地是特定可变大小的地理区域。 匹配服务器可以利用一个或多个可变地理指示符来识别地理区域。 一旦确定了地理区域，则匹配服务器可操作地向位于地理区域内的用户设备发送信息消息。 信息性消息可以包含与地理区域相关的内容。
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