公开(公告)号：US20100048631A1

公开(公告)日：2010-02-25

申请号：US12522010

申请日：2008-01-04

Applicant: Matthew Colin Thor Fyfe ,  John Keily ,  Martin Procter ,  David French Stonehouse ,  Simon Andrew Swain

Inventor： Matthew Colin Thor Fyfe ,  John Keily ,  Martin Procter ,  David French Stonehouse ,  Simon Andrew Swain

IPC: A61K31/454 ,  C07D413/04 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12

CPC classification number: C07D413/04

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

公开(公告)号：US20100035897A1

公开(公告)日：2010-02-11

申请号：US11794641

申请日：2005-12-30

Applicant: Stuart Edward Bradley ,  Matthew Colin Thor Fyfe ,  Gerard Hugh Thomas

Inventor： Stuart Edward Bradley ,  Matthew Colin Thor Fyfe ,  Gerard Hugh Thomas

IPC: A61K31/506 ,  C07D401/14 ,  A61K31/4545 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D401/14

Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.

Abstract translation: 式（I）化合物：其中V为苯基或含有至多3个N原子的6元杂芳基的R1-AVB-R2或其药学上可接受的盐为GPR116的激动剂，可用于治疗肥胖症 ，并用于治疗糖尿病。

公开(公告)号：US20090054444A1

公开(公告)日：2009-02-26

申请号：US11573464

申请日：2005-08-09

Applicant: Matthew Colin Thor Fyfe ,  Vilasben Kanji Shah

Inventor： Matthew Colin Thor Fyfe ,  Vilasben Kanji Shah

IPC: A61K31/495 ,  C07C321/00 ,  C07C381/00 ,  C07D241/10 ,  C07D237/24 ,  A61K31/415 ,  A61P3/10 ,  A61K31/50 ,  C07D231/10 ,  A61K31/192 ,  A61K31/165

CPC classification number: C07C317/44 ,  C07C2601/02 ,  C07C2601/08 ,  C07D231/40 ,  C07D237/20 ,  C07D241/20

Abstract: Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

Abstract translation: 其中R1是环烷基磺酰基的式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。

公开(公告)号：US07214681B2

公开(公告)日：2007-05-08

申请号：US10776584

申请日：2004-02-10

Applicant: Matthew Colin Thor Fyfe ,  Lisa Sarah Gardner ,  Maseo Nawano ,  Martin James Procter ,  Chrystelle Marie Rasamison ,  Karen Lesley Schofield ,  Vilasben Kanji Shah ,  Kosuke Yasuda

Inventor： Matthew Colin Thor Fyfe ,  Lisa Sarah Gardner ,  Maseo Nawano ,  Martin James Procter ,  Chrystelle Marie Rasamison ,  Karen Lesley Schofield ,  Vilasben Kanji Shah ,  Kosuke Yasuda

IPC: A61K31/502 ,  C07D43/02

CPC classification number: C07D231/12 ,  C07D211/34 ,  C07D213/55 ,  C07D233/56 ,  C07D249/08 ,  C07D277/30 ,  C07D277/40 ,  C07D277/46 ,  C07D307/54 ,  C07D309/04 ,  C07D309/08 ,  C07D333/24 ,  C07D333/28 ,  C07D335/02 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D409/10 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D491/08

Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

Abstract translation: 式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。

公开(公告)号：US07074933B2

公开(公告)日：2006-07-11

申请号：US10775464

申请日：2004-02-10

Applicant: Daniel Y. Du ,  Martin James Procter ,  Matthew Colin Thor Fyfe ,  Vilasben Kanji Shah ,  Geoffrey Martyn Williams ,  Karen Lesley Schofield

Inventor： Daniel Y. Du ,  Martin James Procter ,  Matthew Colin Thor Fyfe ,  Vilasben Kanji Shah ,  Geoffrey Martyn Williams ,  Karen Lesley Schofield

IPC: C07D215/38 ,  C07D311/02 ,  A61K31/47

CPC classification number: C07D405/12 ,  C07D215/38 ,  C07D311/14 ,  C07D407/12

Abstract: The invention is directed to a new class of quinolin-zene and z-exc chromen compounds that have been derivatized at the 6-position with a urea or this urea moet, and to then use as androgen antagonists.

Abstract translation: 本发明涉及一种新的喹啉和z-激音色素化合物，它们已经在尿素或这种尿素环上在6位被衍生化，然后用作雄激素拮抗剂。

公开(公告)号：US07064207B2

公开(公告)日：2006-06-20

申请号：US10758582

申请日：2004-01-15

Applicant: Daniel Y. Du ,  Matthew Colin Thor Fyfe ,  Martin James Procter ,  Karen Lesley Schofield ,  Vilasben Kanji Shah ,  Geoffrey Martyn Williams

Inventor： Daniel Y. Du ,  Matthew Colin Thor Fyfe ,  Martin James Procter ,  Karen Lesley Schofield ,  Vilasben Kanji Shah ,  Geoffrey Martyn Williams

IPC: C07D215/16 ,  C07D311/04

CPC classification number: C07D215/36 ,  C07D215/227 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.

Abstract translation: 本发明涉及一类新的6-亚磺酰氨基 - 喹啉-2-酮和6-亚磺酰氨基-2-氧代 - 色烯衍生物，用于雄激素拮抗剂，并减轻与雄激素受体不适当激活相关的病症。