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公开(公告)号：US20090099227A1
公开(公告)日：2009-04-16
申请号：US11794220
申请日：2005-12-23
Applicant: Matthew Colin Thor Fyfe , Gerard Hugh Thomas , Lisa Sarah Bertram , Stuart Edward Bradley , William Gattrell , Chrystelle Marie Rasamison , Vilasben Kanji Shah
Inventor： Matthew Colin Thor Fyfe , Gerard Hugh Thomas , Lisa Sarah Bertram , Stuart Edward Bradley , William Gattrell , Chrystelle Marie Rasamison , Vilasben Kanji Shah
IPC: A61K31/4355 , C07D491/048
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04
Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐或N-氧化物是GPR116的激动剂，可用于治疗肥胖症和治疗糖尿病。
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公开(公告)号：US07582632B2
公开(公告)日：2009-09-01
申请号：US11735685
申请日：2007-04-16
Applicant: Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
Inventor： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
IPC: A61K31/4433 , A61P3/00 , C07D405/12 , C07D413/12 , C07D417/12
CPC classification number: C07D231/12 , C07D211/34 , C07D213/55 , C07D233/56 , C07D249/08 , C07D277/30 , C07D277/40 , C07D277/46 , C07D307/54 , C07D309/04 , C07D309/08 , C07D333/24 , C07D333/28 , C07D335/02 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/10 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/08
Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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3.发明授权公开(公告)号：US07745491B2
公开(公告)日：2010-06-29
申请号：US11573464
申请日：2005-08-09
Applicant: Matthew Colin Thor Fyfe , Vilasben Kanji Shah
Inventor： Matthew Colin Thor Fyfe , Vilasben Kanji Shah
IPC: A61K31/165
CPC classification number: C07C317/44 , C07C2601/02 , C07C2601/08 , C07D231/40 , C07D237/20 , C07D241/20
Abstract: Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 其中R1是环烷基磺酰基的式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US07115745B2
公开(公告)日：2006-10-03
申请号：US10775405
申请日：2004-02-10
Applicant: Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
Inventor： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC: C07D435/02 , A01N43/90
CPC classification number: C07D215/227 , C07D311/08 , C07D311/14 , C07D405/12
Abstract: The present invention is directed to a new class of 6-benzyl urea/thiourea-quinolin-2-one derivatives and 2-oxo-6-benzylurea/thiourea-chromene derivatives. These compound are androgen antagonists and are useful in the treatment of alopecia, acne and other conditions associated with inappropriate activation of the androgen receptor.
Abstract translation: 本发明涉及一类新的6-苄基脲/硫脲 - 喹啉-2-酮衍生物和2-氧代-6-苄基脲/硫脲 - 色烯衍生物。 这些化合物是雄激素拮抗剂，可用于治疗脱发，痤疮和与雄激素受体不适当激活相关的其他病症。
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公开(公告)号：US07098340B2
公开(公告)日：2006-08-29
申请号：US10824456
申请日：2004-04-14
Applicant: Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
Inventor： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC: C07D215/16
CPC classification number: C07D405/12 , C07D215/227 , C07D311/18 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention is directed to a new class of 6-benzylsulfonamido-quinoline/chromene derivatives, to their use as androgen antagonists, and to formulations containing these androgen antagonists.
Abstract translation: 本发明涉及一类新的6-苄基磺酰氨基 - 喹啉/色烯衍生物，其用作雄激素拮抗剂，以及含有这些雄激素拮抗剂的制剂。
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Patent Agency Ranking
公开(公告)号：US07057048B2
公开(公告)日：2006-06-06
申请号：US10758581
申请日：2004-01-15
Applicant: Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
Inventor： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC: C07D215/16 , C07D311/02
CPC classification number: C07D215/227 , C07D311/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D491/08 , C07D491/10
Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
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公开(公告)号：US08193359B2
公开(公告)日：2012-06-05
申请号：US11794220
申请日：2005-12-23
Applicant: Matthew Colin Thor Fyfe , Gerard Hugh Thomas , Lisa Sarah Bertram , Stuart Edward Bradley , William Gattrell , Chrystelle Marie Rasamison , Vilasben Kanji Shah
Inventor： Matthew Colin Thor Fyfe , Gerard Hugh Thomas , Lisa Sarah Bertram , Stuart Edward Bradley , William Gattrell , Chrystelle Marie Rasamison , Vilasben Kanji Shah
IPC: C07D491/048 , A61K31/4355
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04
Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐或N-氧化物是GPR116的激动剂，可用于治疗肥胖症和治疗糖尿病。
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公开(公告)号：US20090221644A1
公开(公告)日：2009-09-03
申请号：US11922830
申请日：2006-06-29
Applicant: Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
Inventor： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
IPC: A61K31/443 , C07D405/12 , A61P3/10
CPC classification number: C07D471/04 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/14 , C07D495/04
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US07009052B2
公开(公告)日：2006-03-07
申请号：US10801910
申请日：2004-03-16
Applicant: Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
Inventor： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC: C07D215/16 , C07D311/74 , A61K31/47
CPC classification number: C07D215/38 , C07D215/36 , C07D215/40 , C07D311/14 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: The present invention is directed to a new class of 6-sulfonamide quinoline and chromene derivative and to their use as androgen antagonists.
Abstract translation: 本发明涉及一类新的6-磺酰胺喹啉和色烯衍生物及其作为雄激素拮抗剂的用途。
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10.发明申请SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS 失效取代的苯乙烯胺及其作为GLUCOKINASE激活剂的用途公开(公告)号：US20090054444A1
公开(公告)日：2009-02-26
申请号：US11573464
申请日：2005-08-09
Applicant: Matthew Colin Thor Fyfe , Vilasben Kanji Shah
Inventor： Matthew Colin Thor Fyfe , Vilasben Kanji Shah
IPC: A61K31/495 , C07C321/00 , C07C381/00 , C07D241/10 , C07D237/24 , A61K31/415 , A61P3/10 , A61K31/50 , C07D231/10 , A61K31/192 , A61K31/165
CPC classification number: C07C317/44 , C07C2601/02 , C07C2601/08 , C07D231/40 , C07D237/20 , C07D241/20
Abstract: Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 其中R1是环烷基磺酰基的式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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