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公开(公告)号：US07074933B2
公开(公告)日：2006-07-11
申请号：US10775464
申请日：2004-02-10
申请人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
发明人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC分类号： C07D215/38 , C07D311/02 , A61K31/47
CPC分类号： C07D405/12 , C07D215/38 , C07D311/14 , C07D407/12
摘要： The invention is directed to a new class of quinolin-zene and z-exc chromen compounds that have been derivatized at the 6-position with a urea or this urea moet, and to then use as androgen antagonists.
摘要翻译： 本发明涉及一种新的喹啉和z-激音色素化合物，它们已经在尿素或这种尿素环上在6位被衍生化，然后用作雄激素拮抗剂。
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公开(公告)号：US07064207B2
公开(公告)日：2006-06-20
申请号：US10758582
申请日：2004-01-15
申请人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
发明人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC分类号： C07D215/16 , C07D311/04
CPC分类号： C07D215/36 , C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/10
摘要： The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
摘要翻译： 本发明涉及一类新的6-亚磺酰氨基 - 喹啉-2-酮和6-亚磺酰氨基-2-氧代 - 色烯衍生物，用于雄激素拮抗剂，并减轻与雄激素受体不适当激活相关的病症。
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公开(公告)号：US20180002373A1
公开(公告)日：2018-01-04
申请号：US15535956
申请日：2015-12-22
IPC分类号： C07K1/107 , C07K14/005 , A61K39/00
CPC分类号： C07K1/1075 , A61K39/00 , A61K39/12 , A61K47/542 , A61K2039/6018 , C07C323/58 , C07C2603/18 , C07K14/005 , C12N2710/16222 , C12N2710/16234
摘要： The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the peptides and conjugates, methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the peptides and conjugates for the same, and uses of the peptides and conjugates in the manufacture of medicaments for the same.
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公开(公告)号：US20120172358A1
公开(公告)日：2012-07-05
申请号：US13396193
申请日：2012-02-14
申请人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse , Simon Andrew Swain , Geoffrey Martyn Williams
发明人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse , Simon Andrew Swain , Geoffrey Martyn Williams
IPC分类号： A61K31/445 , C07D401/10 , C07D413/12 , C07D401/04 , A61K31/454 , A61P3/06 , A61K31/496 , A61K31/5377 , A61K31/506 , A61P3/00 , A61P3/04 , A61P3/10 , C07D211/34 , A61K31/4545
CPC分类号： C07D401/14 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/34 , C07D211/48 , C07D401/04 , C07D401/10 , C07D401/12
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US07115745B2
公开(公告)日：2006-10-03
申请号：US10775405
申请日：2004-02-10
申请人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
发明人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC分类号： C07D435/02 , A01N43/90
CPC分类号： C07D215/227 , C07D311/08 , C07D311/14 , C07D405/12
摘要： The present invention is directed to a new class of 6-benzyl urea/thiourea-quinolin-2-one derivatives and 2-oxo-6-benzylurea/thiourea-chromene derivatives. These compound are androgen antagonists and are useful in the treatment of alopecia, acne and other conditions associated with inappropriate activation of the androgen receptor.
摘要翻译： 本发明涉及一类新的6-苄基脲/硫脲 - 喹啉-2-酮衍生物和2-氧代-6-苄基脲/硫脲 - 色烯衍生物。 这些化合物是雄激素拮抗剂，可用于治疗脱发，痤疮和与雄激素受体不适当激活相关的其他病症。
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公开(公告)号：US07098340B2
公开(公告)日：2006-08-29
申请号：US10824456
申请日：2004-04-14
申请人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
发明人： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC分类号： C07D215/16
CPC分类号： C07D405/12 , C07D215/227 , C07D311/18 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to a new class of 6-benzylsulfonamido-quinoline/chromene derivatives, to their use as androgen antagonists, and to formulations containing these androgen antagonists.
摘要翻译： 本发明涉及一类新的6-苄基磺酰氨基 - 喹啉/色烯衍生物，其用作雄激素拮抗剂，以及含有这些雄激素拮抗剂的制剂。
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公开(公告)号：US07057048B2
公开(公告)日：2006-06-06
申请号：US10758581
申请日：2004-01-15
申请人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
发明人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC分类号： C07D215/16 , C07D311/02
CPC分类号： C07D215/227 , C07D311/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D491/08 , C07D491/10
摘要： The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
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公开(公告)号：US07009052B2
公开(公告)日：2006-03-07
申请号：US10801910
申请日：2004-03-16
申请人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
发明人： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC分类号： C07D215/16 , C07D311/74 , A61K31/47
CPC分类号： C07D215/38 , C07D215/36 , C07D215/40 , C07D311/14 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention is directed to a new class of 6-sulfonamide quinoline and chromene derivative and to their use as androgen antagonists.
摘要翻译： 本发明涉及一类新的6-磺酰胺喹啉和色烯衍生物及其作为雄激素拮抗剂的用途。
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公开(公告)号：US11464853B2
公开(公告)日：2022-10-11
申请号：US16076912
申请日：2017-02-24
申请人： Auckland UniServices Limited , Margaret Anne Brimble , Geoffrey Martyn Williams , Peter Roderick Dunbar
摘要： The invention relates to amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, and pharmaceutical compositions comprising the conjugates. Methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the conjugates for the same, and uses of the conjugates in the manufacture of medicaments for the same are also contemplated.
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公开(公告)号：US10576144B2
公开(公告)日：2020-03-03
申请号：US14392231
申请日：2014-06-27
申请人： AUCKLAND UNISERVICES LIMITED , Margaret Anne Brimble , Thomas Hugh Wright , Peter Roderick Dunbar , Geoffrey Martyn Williams
摘要： The present invention relates to amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the conjugates, methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the conjugates for the same, and uses of the conjugates in the manufacture of medicaments for the same.
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