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57 条记录 (耗时 0.054 秒)

    Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
    53.
    发明授权
    Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases 失效
    非胰岛素受体酪氨酸激酶酪氨酸激酶结构域的晶体

    公开(公告)号：US5942428A

    公开(公告)日：1999-08-24

    申请号：US701191

    申请日：1996-08-21

    申请人： Moosa Mohammadi ,  Joseph Schlessinger ,  Stevan R. Hubbard

    发明人： Moosa Mohammadi ,  Joseph Schlessinger ,  Stevan R. Hubbard

    IPC分类号： C07K14/71 ,  C12N9/12 ,  G01N33/68 ,  C07K14/705

    CPC分类号： G01N33/6842 ,  C07K14/71 ,  C12N9/1205 ,  G01N33/68

    摘要： Crystals of the tyrosine kinase domain of cytoplasmic tyrosine kinases and receptor tyrosine kinases that undergo ligand-mediated receptor dimerization are provided. In particular, crystals of a mutant of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FLGK), alone and in complex with a non-hydrolyzable adenosine triphosphate analogue, are provided. Also provided are the high resolution three dimensional structures of crystalline FLGK, both alone and in co-complex with the adenosine triphosphate analogue, as determined by X-ray diffraction.

    摘要翻译： 提供了经历配体介导的受体二聚化的细胞质酪氨酸激酶和受体酪氨酸激酶的酪氨酸激酶结构域的晶体。 特别地，提供单独的和与不可水解的三磷酸腺苷类似物复合的成纤维细胞生长因子受体1（FLGK）的酪氨酸激酶结构域的突变体的晶体。 还提供了通过X射线衍射测定的结晶FLGK的单分辨率和与三磷酸腺苷类似物的共配合物的高分辨率三维结构。

    Methods for treatment or diagnosis of diseases or disorders associated with an APB domain
    55.
    发明授权
    Methods for treatment or diagnosis of diseases or disorders associated with an APB domain 失效
    用于治疗或诊断与APB结构域相关的疾病或病症的方法

    公开(公告)号：US5807989A

    公开(公告)日：1998-09-15

    申请号：US363215

    申请日：1994-12-23

    申请人： Benjamin Lewis Margolis ,  Joseph Schlessinger ,  Vijay Yajnik

    发明人： Benjamin Lewis Margolis ,  Joseph Schlessinger ,  Vijay Yajnik

    IPC分类号： A61K38/00 ,  C07K14/71 ,  C07K4/12 ,  C07K5/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention concerns methods for diagnosis and treatment of diseases or disorders characterized by abnormal cellular signal transduction involving a newly identified region, herein termed the "APB domain." APB domain binding between proteins is believed to play an important role in signal transduction pathways and, thereby, influence cellular events. Thus, APB mediated activity plays a role in signal transduction pathways and agents modulating APB mediated activity can be used to treat diseases or disorders involving proteins containing APB domains.

    摘要翻译： 本发明涉及用于诊断和治疗特征在于涉及新鉴定区域的异常细胞信号转导的疾病或病症的方法，这里称为“APB结构域”。 认为蛋白质之间的APB结构域结合在信号转导途径中起重要作用，从而影响细胞事件。 因此，APB介导的活性在信号转导途径中起作用，并且调节APB介导的活性的试剂可用于治疗涉及含有APB结构域的蛋白质的疾病或病症。