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公开(公告)号：US5213809A
公开(公告)日：1993-05-25
申请号：US849848
申请日：1992-03-12
IPC分类号： A61K9/00
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
摘要翻译： 公开了用于递送有益剂的分配装置。 该装置包括（1）限定内部空间的半透明壳体，（2）在该空间中任选且目前优选的;（3）在该空间中包含有益剂的热响应组合物，（4）空间消耗构件 装置，（5）与热响应组合物混合的无毒化合物以增强其粘度; （6）壁中的出口，用于增加分配器的内部压力并且同时使有益剂从所述装置排出所述端口;以及（7）包括预水化流体的实施方案，用于紧固输送启动 从送货系统。
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公开(公告)号：US5045082A
公开(公告)日：1991-09-03
申请号：US463109
申请日：1990-01-10
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The invention provides a long-term dispensing device comprising a first agent delivery means for short-term and continuous delivery of agent, retained together with a second agent delivery means capable of long-term and continuous delivery of agent. The combination of first and second agent delivery means provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent. In a preferred embodiment the device includes (1) a short term delivery means for rapid and continuous delivery of agent to the environment of use; and (2) a long-term delivery means comprising a semipermeable wall which surrounds and defines an internal lumen; a means in the lumen for expanding and occupying an increased volume of the lumen; a beneficial agent in the lumen that provides a dispensable formulation to the environment of use; and a means in the device for delivery of the beneficial agent to the environment of use over time.
摘要翻译： 本发明提供了一种长期分配装置，其包括用于短期和连续输送药剂的第一药剂递送装置，与能够长期和连续递送药剂的第二药剂递送装置保持在一起。 第一和第二药剂递送装置的组合提供了一种装置，其中基本上恒定剂量的有益药剂随时间递送到使用环境中。 随后快速递送有益药剂，其次是持续和长期的药剂输送。 在优选实施例中，该装置包括（1）用于将药剂快速且连续地递送到使用环境的短期递送装置; 和（2）包括围绕并限定内腔的半透壁的长期递送装置; 用于扩张和占据体积增加的管腔中的一种装置; 内腔中的有益剂，为使用环境提供可分配的配方; 以及用于将有益剂递送到使用环境的装置中的装置。
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53.发明授权Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method 失效流体输送装置具有具有离子交换膜的电化学泵和相关方法公开(公告)号：US07458965B2
公开(公告)日：2008-12-02
申请号：US10908804
申请日：2005-05-26
IPC分类号： A61K9/22
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/1452 , A61M5/14526 , A61M2005/14513
摘要： The present invention is directed to an apparatus and method for controllably adjusting a fluid delivery device. The device includes an electrochemical pump capable of transporting a fluid. A displaceable member is positioned between a pump product chamber and a reservoir, wherein the pump product chamber is capable of retaining water generated from the pump. The displaceable member is controllably displaced upon generation of water from the electrochemical pump and the reservoir contains the fluid that is delivered upon displacement of the displaceable member.
摘要翻译： 本发明涉及一种用于可控地调节流体输送装置的装置和方法。 该装置包括能够输送流体的电化学泵。 可移动构件定位在泵产品室和储存器之间，其中泵产品室能够保留从泵产生的水。 可移动构件在从电化学泵产生水时可控地移位，并且储存器包含在可移动构件移位时被输送的流体。
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公开(公告)号：US5178866A
公开(公告)日：1993-01-12
申请号：US498121
申请日：1990-03-23
CPC分类号： A61K9/0004
摘要： A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.
摘要翻译： 公开了用于将药物递送到肠和结肠的药物递送装置。 该装置包括用于延迟药物在胃中的输送的外部装置和用于防止流体通过延迟装置的疏水装置。
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公开(公告)号：US20080287464A1
公开(公告)日：2008-11-20
申请号：US12152764
申请日：2008-05-16
IPC分类号： A61K31/519 , A61K47/30 , A61P25/18
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K47/22 , A61K47/26 , A61K47/34
摘要： Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.
摘要翻译： 公开的制剂和相关方法包括在37℃下具有至少5,000cP的粘度的非聚合非水溶性高粘度液体载体材料，其在环境或生理条件下不结晶; 包含丙交酯重复单元的指定线性聚合物; 和一种或多种具有溶剂能力的溶剂。
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公开(公告)号：US5972369A
公开(公告)日：1999-10-26
申请号：US50101
申请日：1998-03-30
申请人： Wouter E. Roorda , Keith E. Dionne , James E. Brown , Jeremy C. Wright , Craig R. Davis , Steven J. Prestrelski , Stelios T. Tzannis
发明人： Wouter E. Roorda , Keith E. Dionne , James E. Brown , Jeremy C. Wright , Craig R. Davis , Steven J. Prestrelski , Stelios T. Tzannis
IPC分类号： A61M37/00 , A61F2/00 , A61F9/007 , A61K9/00 , A61K9/14 , A61K9/22 , A61K31/445 , A61K31/675 , A61K38/00 , A61K47/02 , A61K47/04 , A61K47/26 , A61K47/34 , A61L27/54 , A61L31/16 , A61P31/18 , A61F2/02
CPC分类号： A61K9/0024 , A61K31/445 , A61K31/675 , A61K47/26 , A61K9/0004 , A61F2250/0067 , A61K9/145
摘要： A sustained release delivery system for delivering a beneficial agent is provided. The system includes a reservoir comprising the beneficial agent and a capillary channel in communication with the reservoir and the exterior of the system for delivering the beneficial agent from the system. The capillary channel has a cross-sectional area and a length selected to deliver the beneficial agent at a predetermined rate. The system may further include an outer surface that is impermeable and non-porous during delivery of the beneficial agent. The beneficial agent may be formulated in a glassy sugar matrix.
摘要翻译： 提供了用于递送有益剂的持续释放递送系统。 该系统包括储存器，该储存器包括有益剂和与储存器和系统外部连通的毛细通道，用于从系统输送有益剂。 毛细通道的横截面面积和长度被选定为以预定的速率输送有益剂。 该系统可以进一步包括在递送有益试剂期间不渗透和无孔的外表面。 有益剂可以配制在玻璃糖基质中。
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57.发明授权
公开(公告)号：US5024657A
公开(公告)日：1991-06-18
申请号：US518272
申请日：1990-05-04
CPC分类号： A61M5/1409
摘要： An apparatus is provided for the safe, passive reconstruction of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle "in-line" in an administration set and forming part of an intravenous delivery system, and a cartridge adapted for receiving a beneficial agent or beneficial agent and carrier. The cartridge is plugged into the receptacle to initiate reconstitution of the agent. The apparatus creates first and second delivery modes, in which the delivery rate of the agent to a patient is independent from and dependent upon, respectively, the fluid flow rate through the intravenous delivery system.
摘要翻译： 提供了一种用于药物或其他有益药物的安全，被动重建的装置，而不需要手动重建步骤。 该装置包括壳体，其优选地具有在管理组中的“在线”插座并形成静脉内递送系统的一部分的容器，以及适于接收有益药剂或有益药剂和载体的药筒。 将墨盒插入容器以开始重新配制药剂。 该装置产生第一和第二递送模式，其中药剂对患者的递送速率独立于并且依赖于通过静脉内递送系统的流体流速。
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公开(公告)号：US4473449A
公开(公告)日：1984-09-25
申请号：US421667
申请日：1982-09-22
CPC分类号： A61M1/1696
摘要： An improved method and electrolytic cell for the oxidation of nitrogen-containing waste materials in a dialysate stream used for hemodialysis, hemofiltration or peritoneal dialysis comprises a cylinder having a porous anode and a porous cathode spaced apart in the direction of flow. By flowing the spent dialysate in the direction from the anode to the cathode, and applying sufficient voltage to oxidize chloride ion present to activated chlorine, the waste materials are oxidized to chlorinated intermediates. In the vicinity of the cathode, the chlorinated intermediates react further to yield to nitrogen and carbon dioxide, with the chlorine being reduced back to chloride ion. In this way, the dialysate is regenerated without the net evolution of undesirable chlorine species.
摘要翻译： 用于血液透析，血液滤过或腹膜透析的透析液中用于氧化含氮废物的改进方法和电解槽包括具有在流动方向上间隔开的多孔阳极和多孔阴极的圆筒。 通过将废透析液从阳极流向阴极，并施加足够的电压以将存在的氯离子氧化成活性氯，将废物氧化成氯化中间体。 在阴极附近，氯化中间体进一步反应，产生氮和二氧化碳，氯被还原成氯离子。 以这种方式，透析液被再生而没有不希望的氯物质的净进化。
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