公开(公告)号：US07207982B2

公开(公告)日：2007-04-24

申请号：US10814801

申请日：2004-03-31

申请人： Keith E. Dionne ,  Robert Mosbauer ,  Craig R. Davis ,  John R. Peery

发明人： Keith E. Dionne ,  Robert Mosbauer ,  Craig R. Davis ,  John R. Peery

IPC分类号： A61K9/22 ,  A61F13/00

CPC分类号： A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

摘要： The present invention includes an osmotic pump that includes a means for venting an osmotic composition included in the pump before the internal pressure of the pump has the opportunity to build to such an extent that the pump is structurally compromised, such as when one or more components of the pump are physically separated. The means for venting osmotic material included in an osmotic pump according to the present invention includes a vent that allows the material included in the osmotic composition of the pump to dissipate into an environment of operation at a rate that results in dissipation of the pressure created within the osmotic pump and a reduced potential for subject discomfort or irritation.

公开(公告)号：US06840931B2

公开(公告)日：2005-01-11

申请号：US10279957

申请日：2002-10-25

申请人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

发明人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/52

CPC分类号： A61M5/14276 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14526 ,  A61M5/16813 ,  Y10T29/494

摘要： An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.

摘要翻译： 渗透递送系统流调节器组件，具有流量调节器组件的渗透递送系统以及组装渗透递送系统的方法。 渗透递送系统流模块化组件包括具有穿过本体并且连通主体的两个相对端的孔的主体。 渗透输送系统流量调节器组件的使用减少了在组装系统期间在渗透递送系统的外壳中形成空气或气体袋的机会。 由于渗透输送系统内的空气较少，因此能够提高系统的性能。 流动调节器组件的使用也减少了在渗透输送系统的组装期间有益剂将被浪费的机会。

公开(公告)号：US07407500B2

公开(公告)日：2008-08-05

申请号：US10994615

申请日：2004-11-22

申请人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

发明人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

IPC分类号： A61K9/22 ,  A61F13/00

CPC分类号： A61M5/14276 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14526 ,  A61M5/16813 ,  Y10T29/494

摘要： An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.

摘要翻译： 渗透递送系统流调节器组件，具有流量调节器组件的渗透递送系统以及组装渗透递送系统的方法。 渗透递送系统流模块化组件包括具有穿过本体并且连通主体的两个相对端的孔的主体。 渗透输送系统流量调节器组件的使用减少了在组装系统期间在渗透递送系统的外壳中形成空气或气体袋的机会。 由于渗透输送系统内的空气较少，因此能够提高系统的性能。 流动调节器组件的使用也减少了在渗透输送系统的组装期间有益剂将被浪费的机会。

公开(公告)号：US06190350B1

公开(公告)日：2001-02-20

申请号：US09217824

申请日：1998-12-22

申请人： Craig R. Davis ,  John R. Peery

发明人： Craig R. Davis ,  John R. Peery

IPC分类号： A61M3100

CPC分类号： A61M37/0069 ,  A61J1/00

摘要： An implanter for inserting subcutaneous implants includes a handle for grasping the implanter during implantation, a hollow cannula receiving the implant, and a rod for releasing the implant from the cannula. The rod is longitudinally fixed within the handle while the cannula slides over the rod to release the implant. The cannula is moved over the rod by a sliding actuator mounted in a track of the handle. The actuator is locked in an extended position to prevent unintended release of the implant. Preferably, the implanter is a single-use device having a actuator locking feature preventing reuse.

摘要翻译： 用于插入皮下植入物的注入器包括用于在植入期间抓住植入器的手柄，接收植入物的中空套管以及用于从插管释放植入物的杆。 当套管在杆上滑动以释放植入物时，该杆纵向固定在手柄内。 套管通过安装在手柄的轨道中的滑动致动器在杆上移动。 致动器被锁定在延伸位置以防止植入物的意外释放。 优选地，注入机是具有防止重复使用的致动器锁定特征的一次性装置。

公开(公告)号：US5168426A

公开(公告)日：1992-12-01

申请号：US746380

申请日：1991-08-16

申请人： John R. Hoving ,  Craig R. Davis ,  Michael J. Greaney ,  James R. Flom

发明人： John R. Hoving ,  Craig R. Davis ,  Michael J. Greaney ,  James R. Flom

IPC分类号： E05D11/08 ,  E05D15/42 ,  G06F1/16

CPC分类号： G06F1/1681 ,  G06F1/1616 ,  E05D11/082 ,  E05D15/42 ,  E05Y2900/606 ,  Y10T16/5448 ,  Y10T403/32229 ,  Y10T403/32327

摘要： A hinge mechanism for controlling the movement of the cover panel of a portable computer includes a pivot arm and a slide mechanism. The ends of the pivot arm are pivotally attached to the cover panel and to the housing of the computer, respectively. The cover panel is also pivotally attached to the slide mechanism, which slides along a track mounted in the housing of the computer. The pivot points provide a predetermined frictional resistance to rotational movement whereby the cover panel, which typically includes a display, may be stabilized in an upright position while the computer is in use.

摘要翻译： 用于控制便携式计算机的盖板的移动的铰链机构包括枢转臂和滑动机构。 枢转臂的端部分别枢转地附接到盖板和计算机的壳体。 盖板也可枢转地附接到滑动机构，滑动机构沿着安装在计算机壳体中的轨道滑动。 枢转点为旋转运动提供预定的摩擦阻力，由此通常包括显示器的盖板在计算机使用时可以稳定在直立位置。

公开(公告)号：US4762743A

公开(公告)日：1988-08-09

申请号：US80042

申请日：1987-07-31

申请人： Raymond D. von Alven ,  Craig R. Davis

发明人： Raymond D. von Alven ,  Craig R. Davis

IPC分类号： G01N27/447 ,  B32B3/28 ,  G01N27/26

CPC分类号： G01N27/44704 ,  Y10T428/24479 ,  Y10T428/2457 ,  Y10T428/24628 ,  Y10T428/24669 ,  Y10T428/24694

摘要： Wedge spacers for forming slab gels of increasing cross section are manufactured from strips of thermoplastic material by impressing corrugations into the strips which run lengthwise from one end of each strip to a point along the strip between the two ends. The corrugations decrease in depth from a maximum at the strip end down to flatness at their terminus on the strip face. The forming technique imparts a high degree of reproducibility to the spacers, while still insuring a tight seal.

摘要翻译： 用于形成具有增加横截面的板状凝胶的楔形间隔件通过将波纹压印到从每个条带的一端纵向延伸到在两端之间的条带的点处的条带中，由热塑性材料条制成。 波纹从带状端部的最大深度减小到带状面上的终端处的平坦度。 成型技术赋予间隔物高度可重复性，同时仍保证密封。

公开(公告)号：USD402757S

公开(公告)日：1998-12-15

申请号：US81307

申请日：1997-12-30

申请人： Craig R. Davis ,  John R. Peery

设计人： Craig R. Davis ,  John R. Peery

公开(公告)号：US06524305B1

公开(公告)日：2003-02-25

申请号：US09122073

申请日：1998-07-24

申请人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

发明人： Lewis L. Peterson ,  Fred H. Maruyama ,  Houdin Dehnad ,  Lawton Hom ,  Kevin S. Ly ,  Craig R. Davis ,  John R. Peery

IPC分类号： A61K922

CPC分类号： A61M5/14276 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14526 ,  A61M5/16813 ,  Y10T29/494

摘要： An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.

公开(公告)号：US5972369A

公开(公告)日：1999-10-26

申请号：US50101

申请日：1998-03-30

申请人： Wouter E. Roorda ,  Keith E. Dionne ,  James E. Brown ,  Jeremy C. Wright ,  Craig R. Davis ,  Steven J. Prestrelski ,  Stelios T. Tzannis

发明人： Wouter E. Roorda ,  Keith E. Dionne ,  James E. Brown ,  Jeremy C. Wright ,  Craig R. Davis ,  Steven J. Prestrelski ,  Stelios T. Tzannis

IPC分类号： A61M37/00 ,  A61F2/00 ,  A61F9/007 ,  A61K9/00 ,  A61K9/14 ,  A61K9/22 ,  A61K31/445 ,  A61K31/675 ,  A61K38/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/26 ,  A61K47/34 ,  A61L27/54 ,  A61L31/16 ,  A61P31/18 ,  A61F2/02

CPC分类号： A61K9/0024 ,  A61K31/445 ,  A61K31/675 ,  A61K47/26 ,  A61K9/0004 ,  A61F2250/0067 ,  A61K9/145

摘要： A sustained release delivery system for delivering a beneficial agent is provided. The system includes a reservoir comprising the beneficial agent and a capillary channel in communication with the reservoir and the exterior of the system for delivering the beneficial agent from the system. The capillary channel has a cross-sectional area and a length selected to deliver the beneficial agent at a predetermined rate. The system may further include an outer surface that is impermeable and non-porous during delivery of the beneficial agent. The beneficial agent may be formulated in a glassy sugar matrix.

摘要翻译： 提供了用于递送有益剂的持续释放递送系统。 该系统包括储存器，该储存器包括有益剂和与储存器和系统外部连通的毛细通道，用于从系统输送有益剂。 毛细通道的横截面面积和长度被选定为以预定的速率输送有益剂。 该系统可以进一步包括在递送有益试剂期间不渗透和无孔的外表面。 有益剂可以配制在玻璃糖基质中。