公开(公告)号：US07407942B2

公开(公告)日：2008-08-05

申请号：US11435401

申请日：2006-05-16

申请人： Yat Sun Or ,  Deqiang Niu ,  Zhe Wang

发明人： Yat Sun Or ,  Deqiang Niu ,  Zhe Wang

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20080181868A1

公开(公告)日：2008-07-31

申请号：US12016643

申请日：2008-01-18

申请人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

发明人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

IPC分类号： A61K31/407 ,  A61K38/21 ,  A61P31/12

CPC分类号： C07K5/0804 ,  C07K5/0812 ,  C07K7/06

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US20080032936A1

公开(公告)日：2008-02-07

申请号：US11499917

申请日：2006-08-04

申请人： Yonghua Gai ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

发明人： Yonghua Gai ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

IPC分类号： A61K38/05 ,  C07K5/08

CPC分类号： C07K5/0808 ,  A61K38/00

摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US20080008681A1

公开(公告)日：2008-01-10

申请号：US11768712

申请日：2007-06-26

申请人： Deqiang Niu ,  Dong Liu ,  Joel Moore ,  Guoyou Xu ,  Ying Sun ,  Yonghua Gai ,  Datong Tang ,  Yat Sun Or ,  Zhe Wang

发明人： Deqiang Niu ,  Dong Liu ,  Joel Moore ,  Guoyou Xu ,  Ying Sun ,  Yonghua Gai ,  Datong Tang ,  Yat Sun Or ,  Zhe Wang

IPC分类号： A61K38/21 ,  A61K31/498 ,  A61P31/12 ,  C07D245/04

CPC分类号： C07D245/04 ,  A61K38/212 ,  A61K38/215 ,  C07D403/12 ,  A61K2300/00

摘要： The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

摘要翻译： 本发明涉及包括式I化合物或其药学上可接受的盐，酯或前药的化合物，其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US07265094B2

公开(公告)日：2007-09-04

申请号：US11031465

申请日：2005-01-07

申请人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

发明人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋物，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US07129221B2

公开(公告)日：2006-10-31

申请号：US10436622

申请日：2003-05-13

申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

IPC分类号： A61K31/7048 ,  A61K31/7052 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20050282758A1

公开(公告)日：2005-12-22

申请号：US11154260

申请日：2005-06-16

申请人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

发明人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

IPC分类号： A61K31/7052 ,  A61K45/06 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US06878691B2

公开(公告)日：2005-04-12

申请号：US10429485

申请日：2003-05-05

申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： C07H17/08 ,  A61K31/70 ,  C07H1/00

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20050037982A1

公开(公告)日：2005-02-17

申请号：US10429485

申请日：2003-05-05

申请人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

发明人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

IPC分类号： C07H17/08 ,  A61K31/7048

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US06841664B2

公开(公告)日：2005-01-11

申请号：US10205018

申请日：2002-07-25

申请人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

发明人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

IPC分类号： A61P31/04 ,  C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08

摘要： Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

摘要翻译： 描述了包含治疗有效量的本发明化合物与药学上可接受的载体的新颖的6,11-4-碳桥连酮内酯，药学上可接受的组合物。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。