公开(公告)号：US07273853B2

公开(公告)日：2007-09-25

申请号：US11042720

申请日：2005-01-25

申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US06878691B2

公开(公告)日：2005-04-12

申请号：US10429485

申请日：2003-05-05

申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： C07H17/08 ,  A61K31/70 ,  C07H1/00

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20070244160A1

公开(公告)日：2007-10-18

申请号：US11758225

申请日：2007-06-05

申请人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： A61K31/44 ,  A61P31/04

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US07064110B2

公开(公告)日：2006-06-20

申请号：US10717290

申请日：2003-11-19

申请人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20090324577A1

公开(公告)日：2009-12-31

申请号：US12493847

申请日：2009-06-29

申请人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

发明人： Yat Sun Or ,  Wang Guoqiang ,  Ly Tam Phan ,  Deqiang Niu ,  Nha Huu Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Judson Farmer ,  Guoyou Xu

IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20050159370A1

公开(公告)日：2005-07-21

申请号：US11042720

申请日：2005-01-25

申请人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

发明人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

IPC分类号： A61K31/7052 ,  A61K45/06 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US20050037982A1

公开(公告)日：2005-02-17

申请号：US10429485

申请日：2003-05-05

申请人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

发明人： Yat Or ,  Guoqiang Wang ,  Ly Phan ,  Deqiang Niu ,  Nha Vo ,  Yao-Ling Qiu ,  Yanchun Wang ,  Marina Busuyek ,  Ying Hou ,  Yulin Peng ,  Heejin Kim ,  Tongzhu Liu ,  Jay Farmer ,  Guoyou Xu

IPC分类号： C07H17/08 ,  A61K31/7048

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US20080262208A1

公开(公告)日：2008-10-23

申请号：US12123874

申请日：2008-05-20

申请人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

发明人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

IPC分类号： C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20100041618A1

公开(公告)日：2010-02-18

申请号：US12543155

申请日：2009-08-18

申请人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

发明人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

IPC分类号： A61K31/7048 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20060252712A1

公开(公告)日：2006-11-09

申请号：US11416609

申请日：2006-05-03

申请人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

发明人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

IPC分类号： A61K31/7052 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.