公开(公告)号：US20080269823A1

公开(公告)日：2008-10-30

申请号：US11742230

申请日：2007-04-30

申请人： John E. Burnes ,  Thomas J. Mullen ,  Aleksandra T. Sambelashvili

发明人： John E. Burnes ,  Thomas J. Mullen ,  Aleksandra T. Sambelashvili

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

摘要： Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.

摘要翻译： 用于提供血液动力学有效的融合起搏治疗的预激发间隔（PEI）的自动调整。

公开(公告)号：US07181284B2

公开(公告)日：2007-02-20

申请号：US10803570

申请日：2004-03-17

申请人： John E. Burnes ,  Thomas J. Mullen

发明人： John E. Burnes ,  Thomas J. Mullen

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： The bi-ventricular implantable pulse generator described and depicted herein enables hemodynamic efficiencies for patients suffering from intraventricular conduction delays or conduction blockage. The pulse generator effectively overcomes such conduction delay or block (e.g., left bundle branch block, “LBBB,” or right bundle branch block, “RBBB”) by delivering a novel form of cardiac resynchronization therapy (CRT). Specifically, a single ventricular pre-excitation pacing stimulus is triggered from an atrial event (e.g., intrinsic or evoked depolarization). The triggering event may emanate from the right atrium (RA) or the left atrium (LA). A single ventricular pre-excitation pacing stimulus is delivered prior to the intrinsic depolarization of the other ventricle and thus promotes intraventricular electromechanical synchrony during CRT delivery.

摘要翻译： 本文描述和描述的双心室可植入脉冲发生器能够对患有心室内传导延迟或传导阻塞的患者进行血液动力学效率。 通过递送心脏再同步治疗（CRT）的新形式，脉冲发生器有效地克服了这种传导延迟或阻滞（例如左束支传导阻滞“LBBB”或右束支传导阻滞“RBBB”）。 具体来说，从心房事件（例如内在或诱发的去极化）触发单个心室预激发起搏刺激。 触发事件可能从右心房（RA）或左心房（LA）发出。 在另一个心室的内在去极化之前输送单个心室预激励起搏刺激，从而在CRT输送期间促进脑室内机电同步。

公开(公告)号：US07027871B2

公开(公告)日：2006-04-11

申请号：US10284923

申请日：2002-10-31

申请人： John E. Burnes ,  Luc R. Mongeon

发明人： John E. Burnes ,  Luc R. Mongeon

IPC分类号： A61N1/00

CPC分类号： A61B5/0031 ,  G06F19/00

摘要： An implantable device is described that collects and aggregates data from non-implanted medical devices external from a body of a patient. The device may also collect and aggregate data from medical devices implanted within the body. The implantable device includes a wireless transceiver to acquire physiological data from the external medical devices, and a storage medium to store the physiological data. A processor retrieves the physiological data and communicates the physiological data to a remote patient management system. The device may collect the physiologic data from the various external data sources, possibly over an extended period of time, and stores the data for subsequent upload to a common patient management system. In addition, the implantable device may collect physiological data from other medical devices implanted within the patient. In this manner, the device provides a central point for collection and aggregation of physiological data relating to the patient.

公开(公告)号：US09597505B2

公开(公告)日：2017-03-21

申请号：US12362781

申请日：2009-01-30

申请人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

发明人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

IPC分类号： A61N1/36 ,  A61N1/37 ,  A61N1/372 ,  A61N1/39 ,  A61N1/365 ,  A61N1/08 ,  A61B5/00 ,  A61B5/0428 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/36114 ,  A61B5/04288 ,  A61B5/7217 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3688 ,  A61N1/3702 ,  A61N1/37247 ,  A61N1/37282 ,  A61N1/3962 ,  A61N2001/083

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US09042982B2

公开(公告)日：2015-05-26

申请号：US13400381

申请日：2012-02-20

申请人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

发明人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

IPC分类号： A61N1/00 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

公开(公告)号：US08532779B2

公开(公告)日：2013-09-10

申请号：US12362814

申请日：2009-01-30

申请人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

发明人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

IPC分类号： A61N1/02

CPC分类号： A61N1/08 ,  A61N1/36114 ,  A61N1/37 ,  A61N1/37258 ,  A61N1/37288

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

摘要翻译： 可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。 在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

公开(公告)号：US20120290030A1

公开(公告)日：2012-11-15

申请号：US13105689

申请日：2011-05-11

申请人： Eduardo N. Warman ,  John E. Burnes ,  Koen J. Michels ,  Paul D. Ziegler ,  Lilian Kornet

发明人： Eduardo N. Warman ,  John E. Burnes ,  Koen J. Michels ,  Paul D. Ziegler ,  Lilian Kornet

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3624

摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.

摘要翻译： 本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。 在房性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者传递不适当的治疗。

公开(公告)号：US08290593B2

公开(公告)日：2012-10-16

申请号：US12610157

申请日：2009-10-30

申请人： Robert W. Libbey ,  William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Michael K. Berquist ,  Olivier Blandin ,  Michael Hudziak ,  William L. Johnson ,  John E. Nicholson ,  George Patras ,  Andrew J. Ries ,  Jeffrey Swanson ,  Paul Vahle ,  Thomas J. Olson ,  William K. Wenger ,  Michael R. Klardie ,  Samira Tahvildari

发明人： Robert W. Libbey ,  William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Michael K. Berquist ,  Olivier Blandin ,  Michael Hudziak ,  William L. Johnson ,  John E. Nicholson ,  George Patras ,  Andrew J. Ries ,  Jeffrey Swanson ,  Paul Vahle ,  Thomas J. Olson ,  William K. Wenger ,  Michael R. Klardie ,  Samira Tahvildari

IPC分类号： A61N1/375

CPC分类号： A61N1/3752

摘要： An implantable medical device (IMD) may include at least two separate lead connection assemblies, each with electrical connectors for connecting implantable leads to the IMD. In some examples, a IMD may include a first therapy module configured to generate a first electrical stimulation therapy and a second therapy module configured to generate a second electrical stimulation therapy for delivery to the patient. The IMD may include a first lead connection assembly including a first electrical connector electrically coupled to the first therapy module and a second lead connection assembly including a second electrical connector electrically coupled to the second therapy module. In some examples, the first and second lead connection assemblies are distributed around the outer perimeter of the IMD housing.

摘要翻译： 可植入医疗装置（IMD）可以包括至少两个单独的引线连接组件，每个具有用于将可植入引线连接到IMD的电连接器。 在一些示例中，IMD可以包括被配置为产生第一电刺激治疗的第一治疗模块和被配置为产生用于递送给患者的第二电刺激治疗的第二治疗模块。 IMD可以包括第一引线连接组件，其包括电耦合到第一治疗模块的第一电连接器和包括电耦合到第二治疗模块的第二电连接器的第二引线连接组件。 在一些示例中，第一和第二引线连接组件围绕IMD外壳的外周分布。

公开(公告)号：US20120259389A1

公开(公告)日：2012-10-11

申请号：US13445718

申请日：2012-04-12

申请人： Warren Starkebaum ,  John E. Burnes ,  Roland C. Maude-Griffin

发明人： Warren Starkebaum ,  John E. Burnes ,  Roland C. Maude-Griffin

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61B5/0006 ,  A61B5/14532 ,  A61B5/686 ,  A61N1/36085 ,  A61N1/36171 ,  A61N1/36175

摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In some example, the disclosure relates to systems and methods of treating hyperglycemia in a patient including delivering gastric electrical stimulation (GES) to the patient. Devices, systems and methods according to the disclosure may comprise an implantable stimulator, a blood glucose monitor and/or a food intake sensor. In some examples, a blood glucose level and/or food intake of a patient is detected and GES is delivered to the patient in response to the detection.

摘要翻译： 在一些示例中，本公开涉及用于向患者递送电刺激治疗的系统，装置和技术。 在一些实例中，本公开涉及治疗患者的高血糖症的系统和方法，包括向患者输送胃电刺激（GES）。 根据本公开的装置，系统和方法可以包括可植入刺激器，血糖监测器和/或食物摄取传感器。 在一些示例中，检测到患者的血糖水平和/或食物摄取，并且响应于检测将GES递送给患者。

公开(公告)号：US20120150253A1

公开(公告)日：2012-06-14

申请号：US13400381

申请日：2012-02-20

申请人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

发明人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

摘要翻译： 用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。 在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。