公开(公告)号：US06680062B2

公开(公告)日：2004-01-20

申请号：US09971561

申请日：2001-10-05

申请人： Neelam Muizzuddin ,  Kenneth D. Marenus ,  Daniel H. Maes

发明人： Neelam Muizzuddin ,  Kenneth D. Marenus ,  Daniel H. Maes

IPC分类号： A61K600

CPC分类号： A61Q19/00 ,  A61K8/35 ,  A61K8/368 ,  A61K8/41 ,  A61K8/73 ,  A61K8/97 ,  A61K8/9706 ,  A61K8/987 ,  A61K31/122 ,  A61K31/203 ,  A61K31/60 ,  A61K31/70 ,  A61K36/82 ,  A61K2800/59 ,  A61K2800/75 ,  Y10S514/887 ,  A61K2300/00

摘要： The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.

摘要翻译： 本发明涉及用于局部应用于患有红斑痤疮并用类视黄醇治疗的皮肤的化妆品或药物组合物。 用于治疗酒渣鼻的组合物包含用于治疗酒渣鼻的抗刺激成分和若干其它成分。 其他组分形成水杨酸，植物鞘氨醇，绿茶，桧醇，高戈贡提取物和多糖的混合物。 本发明还提供了一种降低由于患有红斑痤疮的皮肤所感受到的敏感性增加引起的皮肤刺激的方法。 其他成分可有效治疗红斑痤疮病症，特别是治疗红斑痤疮的毛细血管扩张症状。

公开(公告)号：US20110202480A1

公开(公告)日：2011-08-18

申请号：US13060450

申请日：2009-09-04

申请人： Daniel H. Maes ,  Rose Marie Sparacio ,  Denise M. Dicanio ,  Neelam Muizzuddin ,  Lieve Declerq

发明人： Daniel H. Maes ,  Rose Marie Sparacio ,  Denise M. Dicanio ,  Neelam Muizzuddin ,  Lieve Declerq

IPC分类号： G06F17/00 ,  G06F17/10 ,  G06F19/00 ,  G06Q90/00

CPC分类号： G06Q99/00 ,  A61B5/441 ,  A61B8/0858 ,  G06F19/00 ,  G16H10/20 ,  G16H50/50

摘要： Methods of developing equations for objectively assigning or predicting an apparent age are disclosed. Advantageously, the equations of objective apparent age may be based on a relatively small number of critical parameters combined in a way that accounts for all or most of the apparent skin aging in a defined population or sub-population. Despite the relatively small data collection requirements, the present invention includes an objective model of apparent age that is useful for evaluation of products, useful for predicting treatment outcomes and useful for predicting the effects of deteriorative factors. The formalization of an Objective Apparent Age Score allows one to identify the biophysical and biochemical parameters that mostly influence an individual's apparent age, and can be used to select specific anti-aging treatments with increased chances of visible success. The Objective Apparent Age Score may also be used to support marketing claims.

摘要翻译： 公开了客观分配或预测表观年龄的方程的方法。 有利地，客观表观年龄的方程可以基于相对较少数量的关键参数，其组合方式考虑了定义的群体或子群体中的所有或大部分明显的皮肤老化。 尽管数据收集要求相对较小，但是本发明包括可用于评估产品的明显年龄的客观模型，对预测治疗结果有用，并且可用于预测恶化因素的影响。 客观表观年龄分数的形式化允许人们识别主要影响个体表观年龄的生物物理和生物化学参数，并且可以用于选择具有可见成功机会的特定抗衰老治疗。 客观表观年龄分数也可用于支持营销声明。

公开(公告)号：US20100203077A1

公开(公告)日：2010-08-12

申请号：US12306372

申请日：2008-11-21

申请人： Steven F. Schnittger ,  Daniel H. Maes ,  Michael Sullivan

发明人： Steven F. Schnittger ,  Daniel H. Maes ,  Michael Sullivan

IPC分类号： A61K8/96 ,  A61Q19/00

CPC分类号： A61Q19/00 ,  A61K8/9706 ,  A61Q19/02

摘要： Compositions for treating skin containing at least one extract from the genus Trametes and at least one viscosity enhancing synthetic polymer, and methods for whitening skin, treating skin for improvement, or treating skin disorders associated with pigmentation such as uneven pigmentation, skin mottling, or age spots or other dermatological disorders such as eczema, rosacea, hyperkeratinization, and so on.

摘要翻译： 用于治疗皮肤的组合物，其含有至少一种来自所述属的提取物和至少一种增粘的合成聚合物，以及用于增白皮肤，治疗皮肤以改善或治疗与色素沉着相关的皮肤病症如色素沉着不均匀，皮肤斑驳或年龄的方法 斑点或其他皮肤病如湿疹，酒渣鼻，角化过度等。

公开(公告)号：US20100040696A1

公开(公告)日：2010-02-18

申请号：US12507145

申请日：2009-07-22

申请人： Ilse Sente ,  Lleve Declercq ,  Daniel H. Maes ,  Milan Franz Sojka ,  Phillip Cummins ,  Christina G. Fthenakis ,  Nadine A. Pernodet ,  Wilson A. Lee ,  Linda Najdek ,  MaryAnn McKeever-Alfieri ,  Lawrence P. Teta

发明人： Ilse Sente ,  Lleve Declercq ,  Daniel H. Maes ,  Milan Franz Sojka ,  Phillip Cummins ,  Christina G. Fthenakis ,  Nadine A. Pernodet ,  Wilson A. Lee ,  Linda Najdek ,  MaryAnn McKeever-Alfieri ,  Lawrence P. Teta

IPC分类号： A61K9/16 ,  A61K36/899

CPC分类号： A61K8/27 ,  A61K8/11 ,  A61K8/29 ,  A61K8/347 ,  A61K8/365 ,  A61K8/447 ,  A61K8/498 ,  A61K8/63 ,  A61K8/676 ,  A61K8/678 ,  A61K8/97 ,  A61K8/9706 ,  A61K2800/522 ,  A61K2800/56 ,  A61Q17/04 ,  A61Q19/001

摘要： The present invention relates to topical compositions containing a dispersion of composite particles. Each of such composite particles contains one or more core particles encapsulated or entrapped in a polymeric shell. At least some of the core particles are formed of a material capable of causing generation of reactive oxygen species (ROS). Each of the composite particles further contains: (1) a first antioxidant co-encapsulated or co-entrapped with the core particles inside the polymeric shell for quenching or scavenging ROS generated in the vicinity of the core particles, and (2) a second antioxidant coated over the polymeric shell for preventing or reducing oxidative damage to the skin, such as lipid peroxidation. The particle dispersion of the present invention therefore can be readily formulated into topical sunscreen compositions with organic sunscreen agents susceptible to oxidative decomposition or degradation to provide improved protection against skin damage caused by exposure to UV light.

摘要翻译： 本发明涉及含有复合颗粒分散体的局部组合物。 这些复合颗粒中的每一个都包含一个或多个包封或截留在聚合物壳中的芯颗粒。 至少一些核心颗粒由能够产生活性氧（ROS）的材料形成。 每个复合颗粒还包含：（1）与聚合物壳体内的核心颗粒共同包封或共截留的第一抗氧化剂，用于淬灭或清除在核心颗粒附近产生的ROS，和（2）第二抗氧化剂 涂覆在聚合物壳上以防止或减少对皮肤的氧化损伤，例如脂质过氧化。 因此，本发明的颗粒分散体可以容易地配制成具有易于氧化分解或降解的有机防晒剂的局部防晒组合物，以提供改善的防止由于暴露于UV光引起的皮肤损伤的保护。

公开(公告)号：US20090035240A1

公开(公告)日：2009-02-05

申请号：US12127399

申请日：2008-05-27

申请人： Daniel H. Maes ,  Fatemeh Mohammadi ,  Lisa Qu ,  Anna Czarnota ,  Thomas Mammone ,  Lieve Declerco ,  Julius R. Zecchino

发明人： Daniel H. Maes ,  Fatemeh Mohammadi ,  Lisa Qu ,  Anna Czarnota ,  Thomas Mammone ,  Lieve Declerco ,  Julius R. Zecchino

IPC分类号： A61K8/34 ,  A61Q1/08 ,  A61Q1/10

CPC分类号： A61K8/347 ,  A61K8/06 ,  A61K8/37 ,  A61K8/55 ,  A61K8/585 ,  A61K8/892 ,  A61K8/894 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q19/00

摘要： An aqueous based cosmetic composition comprising at least one resveratrol derivative and a water phase containing at least one aqueous phase structuring agent; or an emulsion composition comprising at least one water phase, at least one oil phase containing at least one nonvolatile silicone, and at least one resveratrol derivative.

摘要翻译： 一种含水基化妆品组合物，其包含至少一种白藜芦醇衍生物和含有至少一种水相结构化剂的水相; 或包含至少一种水相，至少一种含有至少一种非挥发性硅氧烷的油相和至少一种白藜芦醇衍生物的乳液组合物。

公开(公告)号：US06635285B2

公开(公告)日：2003-10-21

申请号：US10068950

申请日：2002-02-07

申请人： Éric Dupont ,  Paul Brazeau ,  Christina Juneau ,  Daniel H. Maes ,  Kenneth Marenus ,  Richard Béliveau

发明人： Éric Dupont ,  Paul Brazeau ,  Christina Juneau ,  Daniel H. Maes ,  Kenneth Marenus ,  Richard Béliveau

IPC分类号： A61K3534

CPC分类号： A61Q17/00 ,  A61K8/987 ,  A61K35/60 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S514/859 ,  Y10S514/863 ,  Y10S530/857

摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.

公开(公告)号：US06514506B1

公开(公告)日：2003-02-04

申请号：US09783229

申请日：2001-02-14

申请人： Thomas Mammone ,  Steven F. Schnittger ,  Kenneth D. Marenus ,  Daniel H. Maes

发明人： Thomas Mammone ,  Steven F. Schnittger ,  Kenneth D. Marenus ,  Daniel H. Maes

IPC分类号： A61K600

CPC分类号： A61K8/66 ,  A61K8/9706 ,  A61K38/43 ,  A61Q19/02

摘要： The present invention relates to topical whitening compositions comprising a whitening effective amount of an Ascomycete-derived melanin-degrading enzyme extract and methods of preparing the composition. The compositions provide a whitening effect which occurs by degrading melanin in the skin, yet the compositions themselves do not turn dark in color. The enzyme extract can be derived from Aspergillus fumigatus or from Saccharomyces cerevisiae, and is added to the compositions of the present invention. The compositions containing the enzyme extract are twice as effective as kojic acid in producing a whitening effect on the skin.

摘要翻译： 本发明涉及包含增白有效量的子囊菌来源的黑素降解酶提取物和制备该组合物的局部增白组合物。 组合物提供通过降解皮肤中的黑色素而发生的美白效果，但组合物本身不会变黑。 酶提取物可以来自烟曲霉或酿酒酵母，并加入本发明的组合物中。 含有酶提取物的组合物在产生对皮肤的美白效果方面是曲酸的两倍。

公开(公告)号：US5811083A

公开(公告)日：1998-09-22

申请号：US622730

申请日：1996-03-26

申请人： Edward Pelle ,  Daniel H. Maes

发明人： Edward Pelle ,  Daniel H. Maes

IPC分类号： A61K8/67 ,  A61K31/353 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D311/66 ,  A61K7/40 ,  A61K31/355 ,  C07D311/04

CPC分类号： A61Q19/08 ,  A61K31/353 ,  A61K8/678 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q5/006 ,  C07D311/66 ,  Y10S514/844 ,  Y10S514/847

摘要： Novel tocopherol derivatives useful for regulating skin aging and other skin disorders, as well as compositions containing the derivatives and methods for their use are described. The tocopherol derivative is tocopherol-cysteamine. Such types of skin atrophy to be treated the thinning of the epidermis and/or general degradation of the dermis often characterized by hyperplasia and structural disorganization. Such skin maladies include but are not limited to dry skin, severe dry skin, terosis, dandruff, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses and age-related skin changes.

摘要翻译： 描述了可用于调节皮肤老化和其它皮肤病症的新型生育酚衍生物，以及含有其衍生物和其使用方法的组合物。 生育酚衍生物是生育酚 - 半胱胺。 这种类型的皮肤萎缩被治疗表皮的变薄和/或真皮的一般降解，其特征在于增生和结构紊乱。 这些皮肤疾病包括但不限于干性皮肤，严重干性皮肤，毛病，头皮屑，角化病，牛皮癣，湿疹，瘙痒，老年斑，斑点，黑斑病，皱纹，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤，炎性皮肤病和年龄 相关皮肤变化。

公开(公告)号：US5736537A

公开(公告)日：1998-04-07

申请号：US527145

申请日：1995-09-12

申请人： Joseph Gubernick ,  Daniel H. Maes

发明人： Joseph Gubernick ,  Daniel H. Maes

IPC分类号： C07J1/00 ,  A61K31/565

CPC分类号： A61K8/63 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q5/006 ,  C07J1/0011 ,  Y10S514/844 ,  Y10S514/859 ,  Y10S514/861 ,  Y10S514/863

摘要： Disclosed is the use of dehydroepiandrosterone salicylate in the treatment of skin atrophy. ##STR1## Such types skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells.

摘要翻译： 公开了使用脱水表雄酮水杨酸酯治疗皮肤萎缩。 这种类型的待治疗的皮肤萎缩包括真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少。

公开(公告)号：US5683705A

公开(公告)日：1997-11-04

申请号：US626769

申请日：1996-03-29

申请人： Daniel H. Maes ,  Jules Zecchino ,  Althea Knight

发明人： Daniel H. Maes ,  Jules Zecchino ,  Althea Knight

IPC分类号： A61K8/365 ,  A61K8/37 ,  A61K8/46 ,  A61K8/49 ,  A61K8/60 ,  A61K8/73 ,  A61K31/19 ,  A61K31/20 ,  A61K31/215 ,  A61K31/23 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07C323/41 ,  A61K7/48 ,  C07C233/00

CPC分类号： C07C323/41 ,  A61K31/19 ,  A61K31/20 ,  A61K31/215 ,  A61K31/23 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/46 ,  A61K8/4973 ,  A61K8/60 ,  A61K8/73 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q5/006 ,  Y10S514/852 ,  Y10S514/859 ,  Y10S514/863 ,  Y10S514/944

摘要： Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing amides and bis-amides and methods for their use are described. Such types of abnormal biological conditions or diseases include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

摘要翻译： 可用于治疗或预防异常生物学病症或疾病，和/或改善皮肤的质地或外观的新型含巯基的酰胺和含二硫基的双酰胺以及含有酰胺和双酰胺的组合物和 描述使用它们的方法。 这种类型的异常生物学条件或疾病包括皮肤萎缩，即真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少，以及 其他疾病包括但不限于干性皮肤，严重干性皮肤，头皮屑，痤疮，角化病，牛皮癣，湿疹，皮肤瘙痒，瘙痒，老年斑，斑点，黑斑病，皱纹，疣，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤 ，炎性皮肤病，年龄相关的皮肤变化和需要清洁剂的皮肤。